PRC REVIEW UPH Flashcards by Hanna Mercado

DOC / RDU for aplastic anemia to chronic renal failure ( uremia) ?

Erythropoietin

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The specific RDU anti-CA for CA of the head of he pancreas?

Gemcitabine

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RDU/ DOC For bone marrow depression ( agranulocytosis) is?

G-CSF / Filgrastrim

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Anti-angiogenetic drug for the ff. CA to prevent metastasis? CRC, lung, colon, and breast.

Bevacizumab

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Allergic Contact Dermatitis (ACD) is a type of drug hypersensitivity reaction classified as?

Type IV delayed hypersensitivity

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The single chemotherapy drug for cytotrophoblastic CA cell origin, a common CA in OB associated with pregnancy choriocarcinoma is?

Methotrexate and Cisplatin / Carbopoatin

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The new drug for autoimmune disease as SLE, ABL stimulator for adult sero (+) cases aside from prednisone is?

Belimumab

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GP II- B / III-A Receptor anti-thrombotic -MAB given parenterally for acute coronary syndrome?

Abciximab

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IgG-I -MAB (IL-12 / IL-23 ) indicated as RDU for psoriatic arthritis?

Ustekinumab

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IgG-1 -MAB as a prophylaxis and treatment of premature px with RSV Pneumonitis?

Palivizumab

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A procedure of Px / Tx by starting with a very small dose and then gradually increasing over a period of hrs or days to full therapeutic range is?

Desensitization

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DOC/ RDU for asymptomatic cyst- passer in a human carrier is?

Paromomycin

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PFOR’S ( Pyruvate - Ferredoxin-Oxidoreductase) MOA is for this RDU?

Metronidazole

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DOC for Strongyloidiasis but with SJS as a severe ADR?

Thiabendazole

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DOC for severe falciparum malariae known as endemic cerebral type which is water soluble and given PO is?

Artesunate
Chinese name: Quinhaosu

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RDU/ DOC for IYP ( Idiopathic Thrombocytopenic Purpura) in the absent of thrombopoetin-A is?

Romiplostim

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The thera dose of PO oseltamivir for H1N1 / H5N1 is?

75 mg BID for 5 days

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It inhibits the capping of viral RNA for FLU-A only is?

Amantadine / Rimantadine

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Fusion anti- HIV new drug is?

Enfuvirtide

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NNRTI ANTI-HIV in pregnancy to prevent vertical transmission is?

Efavirenz

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NS5-A / NS5-B ( Semiprevir, Daclastavir, Sofosbuvir) are the new agents for this type of hepatitis?

Hepa C

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MOA of Imiquimod, RDU for moist wart or ano-genital wart is?

Stimulate TNF-a , IL 16, 8 and INF-a

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Exception to the use of fluoroquinolones for infection below 18yo and pregnancy is?

Cystic fibrosis of the pancreas

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The origin of Fluoroquinolones is from the primitive urinary analgesic drug ?

Nalidixic Acid

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Aminocylitol antibiotic as Spectinomycin is the older DOC/ RDU for what disease?

Resistant Gonorrhea

DOC for resistant Gonorrhea?

Ceftriaxone - 3rd generation Cephalosporins

The main cause of bacterial resistance to chloramphenicol is the enzyme?

CAT - Chloramphenicol Acetyltransferase

DOC/ RDU for MI is?

Streptokinase; cheap compared to TPA ie. Alteplase, Tenecteplase, Reteplase

Mast cell degranulation inhibitor which is useful for asthma prophylaxis?

Cromolyn sodium

Gray baby syndrome is a common ADR to chloramphenicol and is characterized by vomiting, flaccidity and ______.

Shock

A cell wall inhibitor that inhibits enolpyruvate transferase involved in the formation of acetylmuramic acid?

Fosfomycin

Cycloserine which is a 2nd anti-TB drug that inhibits d-alanine enzyme?

Racemase

PO Vancomycin is the 2nd line tx for severe cases of this bacterial infection?

Clostridium defficile ( anaerobic)

A monobactsm for gram negative infections exemplified by?

Aztreonam

A natural product from green tea extract for moist wart in above?

Sinecatechin

DOC/ RDU for topical treatment of Actinic Keratosis is?

5- Fluorouracil ( side effect ACD)

Systemic antifungal that inhibits B-1,3- glucan?

Echinocandins

CAPOX, FOLPOX, FOLFIRI , KRAS / NRAS are combined chemotox protocol for this CA?

Colorectal cancer

Philidelphia - chromosomes no. 9, 22 are the common etiology of this cancer?

CML

Bence-jones proteins ( mod. Tamm-horsfall) are the clinical findingsa of this cancer of the bone marrow and bones with aplastic anemia , bone fractures, pain affecting mainly plasma cells , the DOC / RDU are what drugs? (4)

Dexamethasone Thalidomide Lenalidomide Prednisone

Minamata disease from Japan from fishermen produced this common metal poisoning?

Mercury ( Hg)

Vorinostat and Romidepsin are the DOC / RDU for this CA of the skin which is?

Cutaneous T Lymphoma

The advantageous ADR of Bimatoprost is?m

Hypertrichosis of eyelashes

Anti-pruritic local anesthetic for eczema ?

Pramoxine

A wrinkled cigarette paper skin ( atrophy) is a common local ADR of this topical drug ?

Topical Corticosteroid

Organophosphate antipediculoside is?

Malathion

Fumaric acid esters for tx of skin psoriasis is also FDA approved for the treatment of ?

RRMS - Relapsing Remitting Multiple Sclerosis

Sildenafil for the treatment of severe male ED increased cGMP by inhibiting what enzyme?

PDE-5 ( Phosphodiesterase 5)

Fume fever pneumonia is mainly due to inhalation of?

Cadmium

Antidote to propanolol overdose is ?

Glucagon

Diuretic of choice for LS- CHF with pulmonary edema?

Furosemide

Receptor of clonidine treatment for post-menopausal syndrome is ?

Alpha -2 Adrenergic Receptor

Clinically indicated for ADHD , Anorexigenic ( reducing) , and also in excessive sleeping ( narcolepsy).

Modafinil

A vasodilator in essential HPN as fenoldopam acts this specific receptor as?

Dopamine 1 ( D1)

A mydriatic agent , nasal decongestant useful in localizing the lesion of Horner Syndrome?

Phenylephrine

The newest longer acting B-blocker is?

Nebivolol

The longest acting ARB is?

Eprosartan

New drugs for investigation in angina pectoris with vasodilator effects, except?

Ranolazine ( Na channel blocker), PFOX , Trimetazidine

Sacubitril, a neprilysin -inhibitor , is effective only when combined with ?

Valsartan

B-blocker which is not indicated for Chronic CHF to prevent mortality rates?

Metoprolol Bisoprolol Carvedilol Nebivolol

Agranulocytosis and SLE-like syndrome are common ADRs of this anti-arrhythmic drug?

Procainamide

DOC/ RDU for nephrolithiasis and hypercalciuria is?

Thiazide

DOC/ RDU for Meniere’s Syndrome ( vertigo)?

Betahistine

DOC/ RDU for SS ( Serotonin Syndrome)?

Cyproheptadine

A special abnormal receptor found in malignant hyperthermia that relieved abnormal muscle contraction is?

RyR1 ( Ryanodine Receptor 1)

The vitamin for the tx of Werbicke-Korsakoffs psychosis due to alcohol is?

Vit B1 Thiamine

One of the ff is not an ergot alkaloid that produce signs of ergotism : abortion, intellectual dysfunction and vassopasm in the periphery?

Ropinirole Quinagolide Pramipezole

Uteroselective ergot alkaloid for post-partum hemorrhage?

Oxytocin and Methergine / Methylergonovine