NSAID DMARDS

Question 1

Mechanism of paracetamol overdose?

Answer 1

Oxidation to a cytotoxic intermediate called N-acetyl-p-benzoquinoneimine (NAPQI) by phase I cytochrome P450 enzymes ( CYP2E1)

Question 2

NSAID commonly used for closure of PDA?

Answer 2

Indomethacin

Question 3

Rofecoxib and Valdecoxib were withdrawn from the market due to increased incidence of ___________.

Answer 3

Thrombosis

Question 4

MOA of Paracetamol?

Answer 4

Selectively inhibits COX-3

Question 5

TNF-alpha inhibitors.

Answer 5

1. Infliximab
2. Adalimumab
3. Entanercept
4. Certolizumab
5. Golimumab

Question 6

Reasons why we can’t give allopurinol together with azathioprine?

Answer 6

Allopurinol reduces xanthine oxide catabolism of purine analogs, increasing 6-thioguanine nucleotides leading to severe leukopenia.

Question 7

DMARD that inhibits IL-1 and IL-2 receptor production?

Answer 7

Cyclosporine

Question 8

IL -6 inhibitors

Answer 8

Tocilizumab

Question 9

Uricosuric agents?

Answer 9

Probenecid , Sulfinpyrazone

Question 10

Reversible inhibitor of Xanthine oxidase?

Answer 10

Allopurinol

Question 11

Recombinant protein composed extracellular domain of cytotoxic T-lymphocyte associated antigen 4 fused to hinge , CH2, and CH3 domains of Fc domains of human IgG1.

Answer 11

Abatacept

Question 12

Mechanism of Infliximab?

Answer 12

Chimeric IgG1 monoclonal antibody that inhibits binding of TNF-a with its receptors.

Question 13

MOA of allopurinol for treatment of gout?

Answer 13

Decreasing levels of uric acid by inhibiting xanthine oxidase

Question 14

Action of probenecid?

Answer 14

Increase renal elimination of uric acid

Question 15

Drug that inhibits purine synthesis ?

Answer 15

Azathioprine

Question 16

Side effects of prednisone?

Answer 16

1. Hypocalcemia
2. Hyperglycemia
3. Hypertension

Question 17

DMARD of choice to treat RA?

Answer 17

Methotrexate