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GI Pharmacology Flashcards

1
Q

PPI with the least drug to deug interactions?

A

Pantoprazole

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2
Q

Site of absorption of PPI ?

A

Proximal small intestine / duodenum

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3
Q

H2 blocker with CYP450 inhibition.

A

Cimetidine

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4
Q

MOA of bismuth subsalicylate?

A

Forms protective coating on ulcerated tissue.

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5
Q

MOA of Psyllium?

A

Bulk forming laxative

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6
Q

Metoclopramide and domperidone acts as prokinetic agents by what action?

A

Blocking D2 receptors

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7
Q

Melanosis coli may occur as a result of taking what drug?

A

Senna (anthraquinone containing laxatives).

Melanosis coli: non-inflammatory bowel entity in which a brown or black pigment is deposited in the colorectal mucosa.

Anthraquinone laxatives: Senna, Rhubarb, Aloe, Rhamnus, Frangula.

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8
Q

Bisacodyl is what type of laxative?

A

Stimulant ( directly stimulates the ENS)

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9
Q

Deug that may be used in the dissolution of small cholesterol gallstones.

A

Ursodeoxycholic acid

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10
Q

Side effects with long term use of PPI?

A
  1. Vitamin B12 deficiency
  2. Pneumonia
  3. Small benign gastric fundic gland polyps
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11
Q

Increase motility and resting tone of GIT for gastroparesis?

A

Metoclopramide

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12
Q

Metoclopramide adverse effects?

A
  1. Parkinsonian features
  2. Tarditive dyskinesia
  3. Galactorrhea
  4. Akathisia
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13
Q

Blocks muscarinic receptors for treatment of nausea & vomiting?

A

Hyoscine

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14
Q

Loperamide contraindications?

A
  1. Bloody stools
  2. Mucoid stools
  3. Young children
  4. Acute ulcerative colitis
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15
Q

Other drug that may be given to a patient with alopecia, already given with Minoxidil?

A

Finasteride

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16
Q

Effects of pramlintide?

A
  1. Promotes satiety via hypothalamic receptor
  2. Slows down gastric emptying time
  3. Inhibits inappropriate secretion of glucagon
17
Q

Management of Crohn’s disease?

A
  1. Steroids
  2. Surgery
  3. Immunomodulators
18
Q

Drug effective in bleeding esophageal varices?

A

Terlipressin

19
Q

Antihypertensive contraindicated in patients with bleeding esophageal varices?

20
Q

Centrally acting anti-diarrheal agent.

A

Diphenoxylate

21
Q

Complications of long term use of omeprazole?

A
  1. Osteoporosis & bone fracture
  2. Hypomagnesemia
  3. Eradicate H.pylori
22
Q

Components of Creon 25,000 or Pancreatin

A
  1. Amylase
  2. Lipase
  3. Proteases

Pharmacology (14 decks)

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