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Endocrine Pharmacolgy Flashcards

1
Q

Dopamine agonists that may be used in hyperprolactinemia ?

A
  1. Bromocriptine
  2. Pergolide
  3. Cabergolide
  4. Quinagolide
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2
Q

Recombinant IGF-1 that stimulates skeletal muscle growth , amino acid transport, protein synthesis and cell proliferation?

A

Mecasermin

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3
Q

Potential uses of the drug Ocreotide?

A
  1. Acromegaly
  2. Pituitary adenoma (GH-secreting)
  3. Carcinoid
  4. Gastrinoma
  5. Glucagonoma
  6. Variceal bleeding
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4
Q

Difference between intermittent and continuous administration of GnRH agonists?

A

Intermittent: Inc LH , FSH
Continuous: Dec LH , FSH

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5
Q

Substances blocking the uptake of iodide by the gland through competitive inhibition of the iodide transport mechanism.

A

Perchlorate
Pertechnetate
Thiocyanate

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6
Q

Teratogenic effect of methimazole?

A

Aplasia cutis Congenita

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7
Q

Absolute contraindications to RAI administration?

A

Pregnant
Breastfeeding

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8
Q

Drugs that inhibit peripheral conversion of T4 to T3?

A

PTU
Propranolol
Prednisone

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9
Q

Category of Betamethasone & Dexamethasone in terms of duration of action?

A

Long acting glucocorticoids

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10
Q

MOA of Amino-glutethimide?

A

Desmolase inhibitor

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11
Q

Side effects of Estrogen use? (10)

A
  1. Breakthrough bleeding
  2. Nausea
  3. Breast tenderness
  4. Migraine
  5. Thromboembolism (DVTs)
  6. Gall bladder disease
  7. Hypertriglyceridemia
  8. Hypertension
  9. Premature closure of epiphysis
  10. Increase risk of breast & endometrial cancer
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12
Q

Important complication of diethylstilbestrol?

A

1Clear cell vaginal adenocarcinoma In daughters of mothers who took DES

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13
Q

MOA & use of Tibolone?

A
  1. Synthetic steroid with weak estrogenic , progestogenic, and androgenic activity.
  2. Used in menopausal hormone therapy, post menopausal osteoporosis & endometriosis.
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14
Q

Androgen receptor antagonist?

A
  1. Flutamide
  2. Bicalutamide
  3. Nilutamide
  4. Cyproterone
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15
Q

Duration of action of Insulin Detemir?

A

Long acting

“ Ultra Large Dati, Glued = Long acting”
Ultralente
Glargine
Detemir
Degludec

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16
Q

Antidiabetics with higher propensity to cause hypoglycemia especially among the elderly.

A

1st generation sulfonylureas
1. Chlorpropamide
2. Tolbutamide
3. Tolazamide

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17
Q

Most common side effect of metformin?

A

GI disturbance / Diarrhea

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18
Q

Most serious side effect of metformin?

A

Lactic acidosis

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19
Q

Thiazolidine associated with cardiovascular events?

A

Rosiglitazone ( rose red red ang heart)

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20
Q

Thiazolidinedione associated with hepatotoxicity?

A

Troglitazone

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21
Q

MOA of miglitol?

A

a-glucosidase inhibitor ( like acarbose & Voglibose)

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22
Q

Anti-diabetic drugs causes weight gain?

A

“ always SITting kaya tumataba”
Sulfonylurea
Isulin
TZDs

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23
Q

Contraindications of glibenclamide?

A

Hepatic impairment
Renal insufficiency

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24
Q

Contraindications of Pioglitazone?

A

Pregnancy
Chronic liver disease
Congestive Heart Failure

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25
Pioglitazone increases the risk for what disease?
Bladder cancer
26
GLP-1 agonists?
“-tide” Exenatide Liraglutide Lixisenatide Semaglutide Dulaglutide
27
Adverse effect of DPP4-Inhibitors
Pancreatitis
28
DPP-4 Inhibitors ?
1. Sitagliptin 2. Saxagliptin 3. Linagliptin 4. Vidagliptin 5. Tenegliptin “-gliptin”
29
Antidiabetic drug class with uti as a side effect?
SGLT2 Inhibitors: “glifozin” Canaglifozin Dapagliflozin Empagliflozin
30
Instructions to patient who is taking Alendronate?
Take lots of water and keep patient in an upright position for 30 mins after intake of drug.
31
Strontium mechanism of action?
Suppresses bone resorption and increase bone formation
32
Drug that activates calcium sensing receptor, inhibiting PTH secretion
Cinacalcet
33
Side effects of Misoprostol that leads to poor compliance?
Diarrhea
34
A drug producing a net increase in bone formation?
Teriparatide
35
Use of hCG in undescended testes?
Increases weight and vascularity of testes
36
Teriparatide can only be used for 2 years due to the risk to develop?
Osteosarcoma
37
GnRH agonists
1. Leuprolide 2. Gonadorelin 3. Goserelin 4. Histrelin 5. Nafrelin 6. Triptorelin “-relin except Leuprolide “
38
Side effect of a drug for BPH?
Orthostatic hypotension
39
Liraglutide mechanism of action?
Glucose mediated insulin secetagogue Decrease glucagon Decrease post-prandial glucose
40
Drugs used for the management of cushings syndrome?
1. Ketoconazole 2. Metyrapone 3. Trilostane
41
Most dangerous complication of thalidomide?
Agranulocytosis
42
Drug preffered for the management of thyroid storm?
PTU SSKI Propranolol
43
Treatment for patient with pcos, presenting with worsening acne and hirsutism?
Cyproterone
44
Components of contraceptives that acts by increasing viscosity of cervical mucus, and hinders sperm motility
Levonorgestrel Medroxyprogesterone
45
Drugs that cause follicular development?
Menotropin hCG Urofollitropin
46
Cause ovarian hyperstimulation?
Clomiphene Letrozole Menotropins
47
An effect of clomiphene?
Inhibition of Estradiols negative feedback leading to increase of FSH & LH
48
Medical treatment of acromegaly?
GH receptor antagonist Somatostatin analog Dopamine agonist
49
Patient with acromegaly will benefit from this drugs
Pegvisomant Ocreotide Somatostatin
50
Given bolus to address hyperglycemia in a diabetic patient
Rapid acting insulin
51
SE of dapagliflozin (SGLT2 Inh)
1. Increased incidence of UTI 2. Edema 3. Nausea and vomiting 4. Decreased amount of urine
52
Dopamine receptor agonist?
Carbegoline
53
Medical treatment for hyperprolactinemia?
Dopamine agonist : ergot Bromocriptine Pergolide Carbegoline Piribedil
54
Effect of SGLT-2 inhibitors
Enhanced glycemic control Reduction in body weight Reduction in systolic and diastolic blood pressure
55
Moa of conivaptan
Acts as an antagonist of anti diuretic hormone receptor
56
Effects of conivaptan
Increase in urine output Increase net fluid loss Decrease urine osmolality
57
Drug blocking progesterone receptors?
Mifepristone
58
Norethindrone effects?
Acne Weight gain Hirsutism
59
Moam of mifipristone that induces abortion?
Antagonism of progesterone receptor
60
Medication given after pituitary adenoma resection?
Thyroxine for Hypothyroidism
61
Drugs that acts as a somatostatin analog for acromegaly?
Ocreotide
62
Antagonizes the effect of an endogenous aldosterone?
Eplerenone

Pharmacology (14 decks)

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