Cancer Chemotherapy

Question 1

Toxic effects of vincristine ?

Answer 1

Peripheral neuropathy

( check chemo man )

Question 2

Toxic effect of bleomycin?

Answer 2

Pulmonary fibrosis

Question 3

Toxic effect of Methotrexate?

Answer 3

Myelosuppression

Question 4

Toxic effect of Doxorubicin ?

Answer 4

Cardiotoxicity

Question 5

Chemotherapeutic drug that may cause hemorrhagic cystitis ?

Answer 5

Cyclophosphamide

Question 6

Rescue therapy for doxorubicin toxicity?

Answer 6

Dexrazoxane

Question 7

Rescue therapy for Cyclophosphamide toxicity?

Answer 7

MESNA

Question 8

Rescue therapy for Methotrexate toxicity?

Answer 8

Leucoverin

Question 9

Rescue therapy for cisplatin toxicity?

Answer 9

Amifostine

Question 10

Drugs causing pulmonary fibrosis? (6)

Answer 10

“BagA Na MatiGas”
1. Busulfan
2. Bleomycin
3. Bromocriptine
4. Amiodarone
5. Nitrofurantone
6. Methotrexate

Question 11

Moa of Etoposide?

Answer 11

“eTWOposide”
Inhibits DNA topoisomerase-II (DNA Gyrase)

Question 12

Drug for breast , colorectal, head and neck cancer that acts by causing a thymine-less death of cells?

Answer 12

5-FU

Question 13

All-trans retinoic acid is used for what malignancy?

Answer 13

Acute promyelocytic leukemia

Question 14

Drug that may be given to advanced prostate cancer?

Answer 14

Leuprolide

Question 15

Must be given to prostate cancer patient in combination with Leuprolide who is at risk for a flare with exacerbation of pain and increase in obstructive symptoms?

Answer 15

Bicalutamide

Question 16

Possible drug being given to a patient with chronic myelogenous leukemia who presented with pulmonary fibrosis?

Answer 16

Busulfan