Sleep- DORAs DI

Question 1

DORAs in insomnia

Answer 1

Suvorexant, lemborexant, daridorexant

Question 2

Suvorexant brand name

Answer 2

Belsomnra

Question 3

Lemborexant brand name

Answer 3

DayVigo

Question 4

Daridorexant brand name

Answer 4

Quviviq

Question 5

DORA MoA

Answer 5

Turns off wake signaling and assists in getting to sleep and maintaining sleep

Question 6

DORA indications

Answer 6

Sleep onset and maintenance

Question 7

DORAs are what Schedule control?

Answer 7

CIV

Question 8

DORAs in the guidelines

Answer 8

First-line in sleep maintenance

Question 9

Belsomnra ADEs

Answer 9

drowsiness, dizziness, HA, sleep paralysis, abnormal dreams, URTI

Question 10

DayVigo ADEs

Answer 10

drowsiness, dizziness, fatigue, HA, complex sleep behaviors, nightmares

Question 11

Quviviq ADEs

Answer 11

drowsiness, dizziness, fatigue, HA, complex sleep behaviors, hallucinations, sleep paralysis

Question 12

DORA CI

Answer 12

NARCOLEPSY

Question 13

Belsomra and Quviviq DDIs

Answer 13

interactions with 3A4 inhibitors and inducers; decrease dose with moderate 3A4 inhibitors and NOT recommended with strong 3A4 inhibitors

Question 14

DayVigo DDI

Answer 14

decrease dose with weak 3A4 inhibitors, NOT recommended with moderate/strong 3A4 inhibitors

Question 15

DORA onset of action

Answer 15

~30 minutes

Question 16

Half-life of Belsomra

Answer 16

12 hours

Question 17

Half-life of DayVigo

Answer 17

17-19 hours

Question 18

Half-life of Quviviq

Answer 18

8 hours