MS- Ocrelizumab DI

Question 1

Ocrelizumab brand name

Answer 1

Ocrevus

Question 2

Ocrevus indications

Answer 2

CIS, RRMS, active SPMS, PPMS

Question 3

Ocrevus MoA

Answer 3

Binds to CD20 on surface B cells and depletes them from circulation

Question 4

Ocrevus dosing

Answer 4

300mg IV day 1, then 300mg IV 2 weeks later

Future doses of 600mg are administered once every 6 months after that

Question 5

Ocrevus ADEs

Answer 5

Infusion reactions, UTIs, URTIs, HA, nausea

Question 6

How to handle infusion site reactions from Ocrevus

Answer 6

Premedicate with steroids (methylprednisolone 100mg IV 30 minutes before), APAP, or antihistamines (diphenhydramine 30-60 minutes prior)

Question 7

Ocrevus CIs

Answer 7

History of life-threatening infusion reaction or any component of the medication, active HBV

Question 8

Ocrevus warnings/precautions

Answer 8

HBV reactivation, herpes infections, infections, breast cancer/malignancy

Question 9

First drug to show positive results for PPMS

Answer 9

Ocrevus!