MS- Diroximel Fumarate DI

Question 1

Brand name of diroximel fumarate

Answer 1

Vulmerity

Question 2

Vulmerity dosing

Answer 2

231mg PO BID x7 days, then 462mg PO BID with or without food

Question 3

Vulmerity intolerance dosing

Answer 3

Can go down to 231mg PO BID with the intent of going to 462mg PO BID within 4 weeks. If still not tolerated, D/C

Question 4

ADEs of Vulmerity

Answer 4

Same side effects as dimethyl fumarate but with less GI side effects

Question 5

What does a high fat, high calorie meal do to Vulmerity?

Answer 5

It decreases the maximum concentration of Vulmerity’s active metabolite, MMF

Question 6

Alcohol and MMF

Answer 6

Decreases peak MMF plasma concentration