HA- Gepants DI

Question 1

Gepant used in migraine treatment

Answer 1

Rimegepant, ubrogepant, atogepant

Question 2

Rimegepant brand name

Answer 2

Nurtec

Question 3

Ubrogepant brand name

Answer 3

Ubrevly

Question 4

Atogepant brand name

Answer 4

Qulipta

Question 5

Gepant MoA

Answer 5

Small molecule CGRP receptor antagonists

Question 6

Rimegepant indications

Answer 6

Acute AND preventative treatment of migraine in adults

Question 7

Rimegepant dosing

Answer 7

Acute: 75mg PO x1
Preventative: 75mg PO QOD

Question 8

Rimegepant side effects

Answer 8

Abdominal pain, dyspepsia, nausea

Usually well tolerated though

Question 9

Rimegepant CIs

Answer 9

CrCl ≤15ml/min, severe hepatic impairment

Question 10

Ubrogepant indications

Answer 10

Acute treatment of migraine with or without aura

Question 11

Ubrogepant dosing

Answer 11

50-100mg PO x1, can repeat dose after ≥2 hours

Question 12

When Ubrevly needs a dose adjustment

Answer 12

CrCl <30ml/min, avoid use in <15 ml/min

Question 13

Ubrogepant ADEs

Answer 13

Nausea, drowsiness, xerostomia

Question 14

Ubrogepant CI

Answer 14

Strong 3A4 inhibitors

Question 15

Ubrogepant Tmax

Answer 15

1.5 hours, but administration with a high-fat meal delays it by 2 hours

Question 16

Atogepant indications

Answer 16

PREVENTATIVE treatment of episodic migraine

Question 17

Atogepant dosing

Answer 17

10, 30, or 60mg x1

Question 18

Atogepant dose adjustment

Answer 18

<30 ml/min

Question 19

Atogepant ADEs

Answer 19

Constipation, nausea, drowsiness, fatigue, weight loss

Question 20

Atogepant is not recommended in what?

Answer 20

Severe hepatic impairment

Question 21

Adequate trial length of atogepant

Answer 21

8 weeks