Sleep- BZDs DI

Question 1

BZDs used in insomnia treatment

Answer 1

Estazolam, flurazepam, quazepam, temazepam, triazolam

Question 2

BZDs indication for insomnia

Answer 2

Sleep onset and sleep maintenance insomnia

Question 3

Estazolam ADE

Answer 3

Hypokinesia

Question 4

BBW for all BZDs

Answer 4

Use with opioids, abuse and misuse, dependence, withdrawal with abrupt D/C

Question 5

Estazolam CIs

Answer 5

Pregnancy, itraconazole, ketoconazole

Question 6

Flurazepam active metabolite

Answer 6

N-desalkylfurazepam

Question 7

Quazepam active metabolites

Answer 7

2-oxoquazepam, N-desakyl-2-oxoquazepam

Question 8

The active metabolites in flurazepam and quazepam do what?

Answer 8

Increase their half lives

Question 9

Flurazepam and quazepam aren’t good in what patient population and why?

Answer 9

Elderly patients due to hangover effects

Question 10

BZD used in insomnia treatment with the longest half-life

Answer 10

Quazepam- 39 hours

Question 11

Flurazepam half-life

Answer 11

2 hours

Question 12

Triazolam half-life

Answer 12

<2 hours

Question 13

Due to the half-life, what is triazolam good for?

Answer 13

Sleep onset insomnia