MS- Monomethyl Fumarate DI

Question 1

Monomethyl fumarate brand name

Answer 1

Bafiertam

Question 2

Monomethyl fumarate MoA

Answer 2

Same as dimethyl fumarate; it’s the bioequivalent

Question 3

Monomethyl fumarate dosing

Answer 3

95mg BID x7 days, then increase to 190 BID

Question 4

Monomethyl fumarate intolerance dosing

Answer 4

Can go back down to 95mg with the intent of going back to 190mg BID within 4 weeks; if still not tolerated, D/C

Question 5

Monomethyl fumarate ADEs

Answer 5

Same as dimethyl fumarate but with less GI upset d/t it being a lower dose

Question 6

What can you do to reduce flushing with monomethyl fumarate?

Answer 6

Pretreat with nonenteric-coated ASA up to 325mg 30 mins prior to taking dose

Question 7

Storage conditions for unopened container of monomethyl fumarate

Answer 7

Fridge, DO NOT FREEZE

Question 8

Storage conditions for opened container of monomethyl fumarate

Answer 8

Room temperature in the original container protected from light

Question 9

Stability of opened container of monomethyl fumarate

Answer 9

3 months if stored correctly

Question 10

Monomethyl fumarate indications

Answer 10

Relapsing forms of MS, including CIS, SPMS, RRMS