MS- Mitoxantrone DI Flashcards
1
Q
Mitoxantrone brand name
A
Novantrone
2
Q
Mitoxantrone indications
A
SPMS, PRMS, worsening RRMS
NOT INDICATED FOR PPMS!!!
3
Q
Mitoxantrone is reserved for what?
A
Rapidly advancing, refractory MS
4
Q
Mitoxantrone MoA
A
Intercalates with DNA strands causing breaks, and inhibits DNA repair through topoisomerase II
5
Q
Mitoxantrone dosing
A
12mg/m2 IV q3months with a cumulative lifetime dose of 100mg/m2
6
Q
Mitoxantrone ADEs
A
Cardiotoxicity, bone marrow suppression, stomatitis, esophagitis, oral ulceration, N/V, alopecia, HA, fatigue, hepatic dysfunction
7
Q
Terminal half-life of mitoxantrone
A
23-215 HOURS
