skin pathology (rashes)

Question 1

what is the epidermis made from?

Answer 1

stratified kertaising squamous epithelium

Question 2

what are the 4 main reaction patterns? (inflammatory)

Answer 2

spongiotic-intraepidermal oedema

psoriasiform-elongation of edges

lichenoids- basal layer damage

vasiculobullolus- blistering

Question 3

munro micro abscesses

Answer 3

neutophils gather in corneal layer in psoriasis

Question 4

increased epidermal turnover

Answer 4

psoriasis

Question 5

acne distribution?

Answer 5

around sebaceous gland sites-

face
upper back
anterior chest

Question 6

causes of acne

Answer 6

increased androgens at puberty

keratin plugging of pilosebaceous units

Question 7

pathophysiology of acne

Answer 7

sebum plugs pilosebaceous units

keratin and sebum build up to produce black heads/ white heads

rupture causes inaflammation and forgein body granulomas

Question 8

recurrent facial flushing

Answer 8

rosacea

Question 9

who tends to get rosacea

Answer 9

females

Question 10

what can trigger rosacea

Answer 10

sunlight
alcohol
spicy food
stress

Question 11

what is the primary feature of immunobullous disorders?

Answer 11

blisters

Question 12

name 3 immunobullous disorders

Answer 12

pemphigus
bullous pemphigoid
dermatitis herpetiformis

Question 13

most common type of pemphigus

Answer 13

pemphigus vulagris

Question 14

Ig G auto antibodies against desmoglein

Answer 14

pemphigus vulgaris

Question 15

what does desmoglein do?

Answer 15

maintain desmosomal attachments

Question 16

end result odd pemphigus vulgaris

Answer 16

acantholysis

Question 17

superficial blisters

Answer 17

pemphiguS

Question 18

deep blisters

Answer 18

bullous pemphigoiD

Question 19

strong association with coeliac disease

Answer 19

dermatitis herpetiformis

Question 20

intensely itchy lesion elbows, knees and buttock

Answer 20

dermatitis