Cutaneous Drug eruptions Flashcards
what types of drug eruptions can you get?
immunological mediated and non immunological mediated ones
general presentation of drug eruptions?
exanthematous
urticarial
papullosqaumous/pustular/bullous
pigmentation
itch/pain
photosensitivity
who should you consider for a drug eruption/
anyone taking a medication who develops a sudden symmetric rash
what are the risk factors for a drug reaction?
age-young adultsmale
genetics
viral disease -HIV
immune status
what is the most common type of drug eruption?
exanthematous drug eruption
what cell mediates a exanthematous drug eruption?
T cell
what drugs are associated with an exanthematous drug eruption?
penicillins sulphonamide antibiotics allopurinol NSAIDs anti-epileptics streptomycin erythromycin
what mediated an urticarial drug eruption?
IgE or directs release of inflammatory markers from mast cells
what type of drug eruption is acne?
pustular/bullous?
what drugs can cause acne?
glucocorticoids
androgens
what drugs can cause bullous pemphigoid?
ACEi
penicillin
furosemide
what drug eruption is described?
well demarcated round/ovoid plaques
red and painful
hands, lips and genitalia and oral mucosa
can re-occur on same site on re-exposure
fixed drug eruption
drugs associated with fixed drug eruptions?
NSAIDS
paracetamol
tetracycline, doxycyline
carbamazepine
what are the major patterns of cutaneous photo toxicity?
exaggerated sunburn
immediated prickling
delayed 3-5 days erythema and pigmentation
increased skin fragility
management of drug eruptions?
discontinue drug topical steroids antihistamines drug bracelets reported via yellow card scheme
