pharmacology and the skin

Question 1

what are the 3 major routes of drug administration for the skin?

Answer 1

topical
transdermal
subcutaneous/depot

Question 2

what is the single most important layer to drug penetration?

Answer 2

stratum corneum

Question 3

what makes up the stratum corneum?

Answer 3

corneocytes (hardened dead keratinocytes)

Question 4

describe the topical route of drug administration?

Answer 4

applied directly to skin surface

Question 5

describe the subcutaneous route of administration?

Answer 5

drug delivered by a needle-inserted into the fatty tissue just beneath the skin surface

Question 6

describe the transdermal drug delivery?

Answer 6

drug is usually incorporated into an adhesive patch applied to the epiderrmis

Question 7

advantages of transdermal drug delivery?

Answer 7

low cost

can be incorporated into vehicles

Question 8

disadvantages of transdermal drug delivery?

Answer 8

skin irritation/toxicity

Question 9

disadvantages of subcutaneous deilvery?

Answer 9

injection volume is limited

Question 10

advantages of subcutaneous delivery?

Answer 10

absorption is pretty slow
good for many drugs
pretty simple and painless