Skin Flashcards
What are the three layers of the skin?
1-Epidermis
2-Dermis
3-Hypodermis
Where is thick skin (glabrous skin) found?
palms and soles (thick epidermis and stratum lucidum)
Where is thin skin (hairy skin) found?
Everywhere besides palms and soles (thin epidermis, no stratum lucidum)
What are the 4 cell layers of the epidermis?
1-Basal cell layer
2-Spinous cell layer
3-Granular cell layer (lipid coating to prevent dehydration)
4-Cornified cell layer (cross linked keratin)
cells that undergo exocytosis producing a lipid rich barrier are called what?
Lamellar granules
Organelles disappear in what layer in thick skin?
Stratum lucidum
Keratin filaments serving as scaffold for lipids and proteins provide what?
Barrier function
*defects in this lead to eczema and may contribute to asthma
Hairs, sebaceous and eccrine glands are characteristic of what?
Thin skin
What are 3 important cells types of the epidermis?
1-Melanocytes (produce melanin to protect from UV, neural crest origin, in basal layer)
2-Langerhan cells (antigen presenting cells)
3-Merkel cells (light touch and texture sense)
Depigmentation caused by loss of increased activity of melanocytes is called what?
Vitiligo
Sun exposure can cause what two kinds of keratinocyte cancers?
1-Basal cell carcinoma (very common, rarely metastasizes)
2-Squamous cell carcinoma (second most common)
The third most common skin cancer that is more apt to metastasize and is responsible for 75% skin cancer death is what?
Melanoma
A very rare yet aggressive and hard to treat skin cancer is called what?
Merkel cell carcinoma
What sensory receptors sense light touch in dermal papillae?
Meissner’s corpuscle
What sensory receptors sense vibration and pressure in the hypodermis?
Pacinian corpuscle
