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PHARMA > SKELETAL MUSCLE RELAXANTS > Flashcards

SKELETAL MUSCLE RELAXANTS Flashcards

1
Q

used to produce muscle paralysis to facilitate surgery or assisted ventilation

A

NMB drugs

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2
Q

used to reduce abnormally elevated tone caused by neurologic or muscle end plate disease

A

Spasmolytic drugs

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3
Q

DEPOLARIZING BLOCKADE

A

paralysis from persistent depolarization of the end plate (succinylcholine)

ineffective muscle contraction

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4
Q

NONDEPOLARIZING OR STABILIZING BLOCKADE

A

competitive antagonists at the acetylcholine receptor of the end plate
(tubocurarine)

reversible by increasing Ach or giving Ach inhibitors ( neostigmine, edrophonium, physostigmine, pyridostigmine, rivastigmine, donepezil)

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5
Q

Lethal Injection Drugs

A

Thiopental 5g
Pancuronium 100mg
Potassium Chloride 100mEq

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6
Q

NONDEPOLARIZING NMB DRUGS

A

Natural Alkaloid
Isoquinoline
Amino-steroid

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7
Q

NATURAL ALKALOID

A

TUBOCURARINE

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8
Q

ISOQUINOLINE

A

ATRACURIUM
CISATRACURIUM
MIVACURIUM

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9
Q

AMINOSTEROID

A

VECURONIUM
ROCURONIUM
PANCURONIUM

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10
Q

undergoes Hoffman Elimination or rapid spontaneous breakdown yielding Laudanosine (seizure causing)

A

ATRACURIUM AND CISATRACURIUM

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11
Q

undergoes bile elimination

A

Vecuronium

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12
Q

with additional moderate block on cardiac muscarinic receptors

A

Pancuronium

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13
Q

metabolized by pseudocholinesterase

A

mivacurium, succinylcholine

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14
Q

most rapid onset

A

rocuronium

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15
Q

main reversing agent

A

NEOSTIGMINE

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16
Q

reversing agent for ROCURONIUM

A

SUGAMMADEX

17
Q

NMB DOF for hemodynamically compromised patients

A

CISATRACURIUM, VECURONIUM, ROCURONIUM

18
Q

short acting nondepo NMB

A

MIVACURIUM

DOA: 10-20 MINUTES

19
Q

rare interaction of succinylcholine and possibly tubocurarine with inhaled anesthetic halothane

A

MALIGNANT HYPERTHERMIA

20
Q

early sign of malignant hyperthermia

A

trismus

21
Q

DEPOLARIZING NMB

A

SUCCINYLCHOLINE

22
Q

NMB OF CHOICE FOR RAPID SEQUENCE INDUCTION

A

SUCCINYLCHOLINE

23
Q

MOA: SUCCINYLCHOLINE

A

Agonist at ACh N receptors causing initial twitch then persistent depolarization

24
Q

PHASES OF DEPOLARIZING BLOCKADE

A

Phase 1 DEPOLARIZATION
membrane depolarizes with initial electric discharge

transient fasciculations followed by flaccid paralysis

Phase 2 DESENSITIZATION
membrane repolarizes but receptor is desensitized to the effects of ACh

25
Q

Centrallt Acting Spasmolytic Drugs
GABA B AGONIST
Facilitates spinal inhibition of motor neurons

A

BACLOFEN

26
Q

Centrally Acting Spasmolytic Drugs

A

BACLOFEN

ORPHENADRINE, CHLORPHENESIN, METHOCARBAMOL, CYCLOBENZAPRINE

DIAZEPAM

TIZANIDINE

27
Q

Spasmolytic Drug with strong antimuscarinic effec

A

ORPHENADRINE
CHLORPHENESIN
METHOCARBAMOL
CYCLOBENZAPRINE

28
Q

Spasmolytuc drug with alpha 2 agonist effect in th spinal cord

A

TIZANIDINE

29
Q

DIRECT ACTING MUSCLE RELAXANTS

A

DANTROLENE

EPERISONE

30
Q

MOA: DANTROLENE

A

CCB

block RYR1 Ca release channels in the SR of skeletal muscles

31
Q

MOA: EPERISONE

A

relaxes both skeletal and vascular smooth muscles

PHARMA (15 decks)

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