Opioid Analgesics and Antagonists

Question 1

Triad of Opioid Overdose

Answer 1

Pupillary Constriction
Comatose State
Respiratory Depression

Question 2

Opioid with shortest half-life

Answer 2

REMIFENTANIL

3-4 MINS.

Question 3

Opioid with longest half-life

Answer 3

BUPRENORPHINE

4-8 HRS.

Question 4

Opioid effects that does not diminish with continuous opioid use

Answer 4

Mioisis
Constipation
Convulsions

Question 5

Opioid Side effects not mediated by opioid receptors

Answer 5

Nausea, Vomiting, Hypotension, Pruritus

Question 6

OPIOID RECEPTORS

Answer 6

mu1, mu2, kappa, delta

Question 7

Mu receptors agonists

Answer 7

Synthetic opioids
Endorphine
Morphine

Question 8

Kappa receptor agonist

Answer 8

Dynorphins

Question 9

Delta receptor agonist

Answer 9

Enkephalins

Question 10

Opioids Partial Agonists

Answer 10

DOH
Dihydrocodeine
Oxycodone
Hydrocodone

CO-DEX
Codeine
Dextrometorphan

Question 11

Opioid Weak Agonists

Answer 11

Propoxyphene
Levopropoxyphene
Dextropropoxyphene

Question 12

Opioid Mixed Agonist-Antagonist

Answer 12

Buprenorphine
Nalbuphine
Butorphanol
Pentazocine
Levallorphan

Question 13

Use: Dextrometorphan, Codeine

Answer 13

Cough suppression

Question 14

May cause fatal arrhythmia

Answer 14

Weak agonists

Propoxyphene
Levopropoxyphene
Deltapropoxyphene

Question 15

strong agonists of mu and kappa receptors

Answer 15

DOH

Dihydrocodeine
Oxycodone
Hydrocodone

Meperidine (Pethidine)

Question 16

partial mu receptor agonists and antagonist at kappa and delta receptors

Answer 16

mixed

Butorphanol
Nalbuphine
Buprenorphine
Pentazocine
Levallorphan

Question 17

used in alcohol dependence

Answer 17

mixed

Question 18

commonly used in suicides

Answer 18

weak agonists

Question 19

weak agonist that can be used as anti-tussive

Answer 19

levopropoxyphene

Question 20

Strong kappa agonist and partial mu antagonist

Answer 20

Nalbuphine

Question 21

kappa agonist and weak mu antagonist

Answer 21

Pentazocine

Question 22

Effects resistant to Naloxone reversal

Answer 22

Mixed

Question 23

Used in opioid withdrawal states

Answer 23

Buprenorphine

Question 24

Receptor for marked constipation

Answer 24

mu 2

Question 25

Used in postoperative shivering

Answer 25

Butorphanol

Question 26

FULL AGONIST

Answer 26

phenanthrenes phenylpiperidine Meperidine (Pethidine) phenylheptylamines

Question 27

PHENANTHRENES

Answer 27

morphine hydromorphone oxymorphone Heroin

Question 28

PHENYLPIPERIDINE

Answer 28

``` fentanyl sufentanil alfentanil remifentanil ohmefentanyl ```

Question 29

PHENYLHEPTYLAMINES

Answer 29

methadone levomethadyl acetate levorphanol

Question 30

Used in opioid dependence

Answer 30

phenylheptylamines

Question 31

Normeperidine is contraindicated in patients with

Answer 31

seizure lowers seizure threshold

Question 32

May be given transdermally or via lollipop

Answer 32

Phenylpiperidine

Question 33

TRUE OR FALSE. MEPERIDINE CAUSES MIOSIS.

Answer 33

False. MEPERIDINE causes MYDRIASIS.

Question 34

has the most pronounced anti-shivering effect

Answer 34

MEPERIDINE

Question 35

May cause QT prolongation as a side effect

Answer 35

METHADONE

Question 36

OPIOID ANTAGONIST

Answer 36

``` NALOXONE NALTREXONE NALMEFENE ALVIMOPAN METHYLNALTREXONE ```

Question 37

DOC for opioid overdose

Answer 37

NALOXONE

Question 38

DOC for opioid and alcohol dependence

Answer 38

NALTREXONE

Question 39

DUAL ACTING

Answer 39

TRAMADOL | TAPENTADOL

Question 40

MOA: TRAMADOL, TAPENTADOL

Answer 40

weak mu receptor agonist inhibits neuronal reuptake of serotonin and norepinephrine inhibits pain neurotransmission