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PHARMA > Opioid Analgesics and Antagonists > Flashcards

Opioid Analgesics and Antagonists Flashcards

1
Q

Triad of Opioid Overdose

A

Pupillary Constriction
Comatose State
Respiratory Depression

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2
Q

Opioid with shortest half-life

A

REMIFENTANIL

3-4 MINS.

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3
Q

Opioid with longest half-life

A

BUPRENORPHINE

4-8 HRS.

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4
Q

Opioid effects that does not diminish with continuous opioid use

A

Mioisis
Constipation
Convulsions

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5
Q

Opioid Side effects not mediated by opioid receptors

A

Nausea, Vomiting, Hypotension, Pruritus

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6
Q

OPIOID RECEPTORS

A

mu1, mu2, kappa, delta

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7
Q

Mu receptors agonists

A

Synthetic opioids
Endorphine
Morphine

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8
Q

Kappa receptor agonist

A

Dynorphins

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9
Q

Delta receptor agonist

A

Enkephalins

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10
Q

Opioids Partial Agonists

A

DOH
Dihydrocodeine
Oxycodone
Hydrocodone

CO-DEX
Codeine
Dextrometorphan

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11
Q

Opioid Weak Agonists

A

Propoxyphene
Levopropoxyphene
Dextropropoxyphene

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12
Q

Opioid Mixed Agonist-Antagonist

A 
Buprenorphine
Nalbuphine
Butorphanol
Pentazocine
Levallorphan
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13
Q

Use: Dextrometorphan, Codeine

A

Cough suppression

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14
Q

May cause fatal arrhythmia

A

Weak agonists

Propoxyphene
Levopropoxyphene
Deltapropoxyphene

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15
Q

strong agonists of mu and kappa receptors

A

DOH

Dihydrocodeine
Oxycodone
Hydrocodone

Meperidine (Pethidine)

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16
Q

partial mu receptor agonists and antagonist at kappa and delta receptors

A

mixed

Butorphanol
Nalbuphine
Buprenorphine
Pentazocine
Levallorphan
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17
Q

used in alcohol dependence

A

mixed

18
Q

commonly used in suicides

A

weak agonists

19
Q

weak agonist that can be used as anti-tussive

A

levopropoxyphene

20
Q

Strong kappa agonist and partial mu antagonist

A

Nalbuphine

21
Q

kappa agonist and weak mu antagonist

A

Pentazocine

22
Q

Effects resistant to Naloxone reversal

A

Mixed

23
Q

Used in opioid withdrawal states

A

Buprenorphine

24
Q

Receptor for marked constipation

A

mu 2

25
Q

Used in postoperative shivering

A

Butorphanol

26
Q

FULL AGONIST

A

phenanthrenes

phenylpiperidine

Meperidine (Pethidine)

phenylheptylamines

27
Q

PHENANTHRENES

A

morphine
hydromorphone
oxymorphone
Heroin

28
Q

PHENYLPIPERIDINE

A 
fentanyl
sufentanil
alfentanil
remifentanil
ohmefentanyl
29
Q

PHENYLHEPTYLAMINES

A

methadone
levomethadyl acetate
levorphanol

30
Q

Used in opioid dependence

A

phenylheptylamines

31
Q

Normeperidine is contraindicated in patients with

A

seizure

lowers seizure threshold

32
Q

May be given transdermally or via lollipop

A

Phenylpiperidine

33
Q

TRUE OR FALSE.

MEPERIDINE CAUSES MIOSIS.

A

False.

MEPERIDINE causes MYDRIASIS.

34
Q

has the most pronounced anti-shivering effect

A

MEPERIDINE

35
Q

May cause QT prolongation as a side effect

A

METHADONE

36
Q

OPIOID ANTAGONIST

A 
NALOXONE
NALTREXONE
NALMEFENE
ALVIMOPAN
METHYLNALTREXONE
37
Q

DOC for opioid overdose

A

NALOXONE

38
Q

DOC for opioid and alcohol dependence

A

NALTREXONE

39
Q

DUAL ACTING

A

TRAMADOL

TAPENTADOL

40
Q

MOA: TRAMADOL, TAPENTADOL

A

weak mu receptor agonist

inhibits neuronal reuptake of serotonin and norepinephrine

inhibits pain neurotransmission

PHARMA (15 decks)

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