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PHARMA > Parkinson's Drugs > Flashcards

Parkinson's Drugs Flashcards

1
Q

Parkinson’s Dse is also known as

A

paralysis agitans

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2
Q

PD is caused by

A

degeneration of dopaminergic neurons in substantia nigra

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3
Q

PD Triad

A

Bradykinesia, Resting Tremors, Dystonia

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4
Q

Manifestations of PD

A

It’s a TRAP.

Tremor
Rigidity
Akinesia
Postural Instability

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5
Q

Pathological Hallmark of PD

A

loss if pigmented, dopaminergic neurons of the substantia nigra pars compacta

with the appearance of intracellular inclusions known as LEWY BODIES

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6
Q

Principal component of Lewy Bodies

A

aggregated alpha-synuclein

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7
Q

Drug Induced Parkisonism

A 
Typical antipsychotics (Dopamine antagonists)
Reserpine (depletes catecholamine stores)
MPTP (protoxin damaging dopaminergic neurons)
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8
Q

alternating periods of improved mobility and akinesia during treatment that is UNRELATED to timing of doses

A

ON-OFF PHENOMENA

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9
Q

alternating periods of improved mobility and akinesia during treatment that is RELATED to timing of doses

A

WEARING-OFF PHENOMENA

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10
Q

Drugs causing Livedo Reticularis

A

A man reads FHM and GQ

Amantadine
Hydroxyurea
Minocycline
Gemcitabine
Quinidine
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11
Q

Drugs for Huntington Disease

A

TETRABENAZINE, RESERPINE

depletes amine transmitters (Dopamine) from nerve endings by reversibly inhibiting human vesicular monoamine transporter type 2 (VMAT2) resulting to decrease uptake of monoamines

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12
Q

Drugs for Tourette’s Syndrome

A

Haloperidol, Pimozide

Blocks central D2 receptora, reduce vocal and motor tic frequency and severity

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13
Q

dopamine precursor

A

Levodopa-Carbidopa

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14
Q

DOC for PD

A

Levodopa-Carbidopa

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15
Q

should not be given to patients taking L-dopa

A

Phenothiazine

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16
Q

AE of L-dopa + Carbidopa

A

On-Off phenomena, Wearing-off phenomena

17
Q

ERGOT DOPAMINE AGONIS

A

Bromicriptine
Pergolide
Cabergoline
Piribedil

18
Q

MOA: DOPAMINE AGONIST ERGOT

A

partial agonist at D2 receptors in brain

Piribedil - acts as a D3 agonist and A2 antagonist

19
Q

USE: DOPAMIN AGONIST ERGOT

A

PD, LEVODOPA INTOLERANCE, HYPERPROLACTINEMIA

20
Q

AE OF BROMOCRIPTINE

A

erythromelalgia and pulmonary infiltrate

21
Q

DOPAMINE AGONIST NON ERGOT

A

PRAMIPEXOLE, ROPINIROLE

22
Q

MOA: DOPAMINE AGONIST NON ERGOT

A

Partial agonist at D2 (pramipexole) and D3 (ropinirole)

23
Q

USE: NON ERGOT

A

PD, RESTLESS LEGS SYNDROME, ON-OFF PHENOMENON

24
Q

OPIOID DOPAMINE AGONIS

A

APOMORPHINE

25
Q

MOA: APOMORPHINE

A

agonist at D2

antagonist at 5HT and alpha adrenoceptors

26
Q

USE: APOMORPHINE

A

rescue tx for off-periods of PD, Alcoholism, opiate addiction, erectile dysfunction, alzheimer’s

27
Q

Premedicate with ______ before taking Apomorphine

A

TRIMETHOBENZAMIDE

28
Q

SELECTIVE MAO B inhibitors

A

SELEGILINE
RASAGILINE

no cheese effect

29
Q

COMT INHIBITORS

A

ENTACAPONE, TOLCAPONE

30
Q

ANTICHOLINERICS FOR PD

A

BENZTROPINE
BIPERIDEN
TRIHEXYPHENIDYL
PROCYCLIDINE

31
Q

COMT inhibitor in the brain

A

Tolcapone

32
Q

COMT inhibitor at periphery

A

Entecapone, Tolcapone

33
Q

Notable side effect of COMTi

A

Orange urine

Hepatotoxicity - Tolcapone only

34
Q

Drug that potentiates dopaminergic function by influencing the synthesis, release or reuptake of dopamine and is also used for influenza.

A

AMANTADINE

35
Q

Drug class that decreseas the excitatory actions of cholinergic neurons on cells in the striatum by blocking muscarinic receptors.

A

ANTICHOLINERGICS

36
Q

AE: Anticholinergics

A

Atropine-like effects (urinary retention, constipation, dry mouth)

37
Q

Acute Dystonia

A

Diphenhydramine

38
Q

Parkinsonism and Rabbit Syndrome

A

Benztropine

39
Q

Akathisia

A

Diphenhydramine

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