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PHARMA > ANTIDEPRESSANTS > Flashcards

ANTIDEPRESSANTS Flashcards

1
Q

ANTIDEPRESSANTS

A 
Tricyclic AD
SSRI
SNRI
Serotonin Receptor Antagonists
Heterocyclic AD
MAO Inhibitors
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2
Q

TRICYCLIC ANTIDEPRESSANT

A 
Imipramine
Clomipramine
Desipramine
Amitryptyline
Nortryptiline
Doxepin
Protriptyline
Trimipramine
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3
Q

SSRI

A 
Fluoxetine
Paroxetine
Citalopram
Escitalopram
Sertraline
Fluvoxamine
Vilazodone
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4
Q

SNRI

A

Venlafaxine
Duloxetine
Desvenlafaxine
Milnacipran

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5
Q

Serotonin Antagonist

A

Trazodone
Nefazodone
Vortioxetine

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6
Q

TETRACYCLIC ANTIDEPRESSANT

A

Amoxapine
Maprotiline

Mirtazapine

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7
Q

UNICYCLIC AMINOKETONE

A

Bupropion

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8
Q

MAO INHIBITORS

A

Phenelzine
Tranylcypromine
Isocarboxazid
Selegiline

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9
Q

3Cs of TCA Overdose

A

Coma
Convulsions
Cardiotoxicity

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10
Q

Toxic dose of Tricyclic Antidepressant

A

7mg/kg

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11
Q

Lethal dose of Tricyclic Antidepressant

A

15mg/kg

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12
Q

What would you give to reverse cardiotoxicity due to tricyclic antidepressant overdose?

QRS duration>100 msec or ventricular arrhythmias

A

Bicarbonate

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13
Q

Drugs that can cause Serotonin Syndrome

A 
MAOi
TCA
Dextromethorphan
Meperidine
St. John's Wort
MDMA (ecstasy)
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14
Q

Manifestation of Serotonin Syndrome

A

FAT CHD

Fever Agitation Tremor

Clonus Hyperreflexia Diaphoresis

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15
Q

MOA: TCA

A

blocks NE and 5-HT transporters (prevents reuptake)

plus

blockade of ANS and histamine receptors

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16
Q

very useful for patients with psychomotor retardation, sleep disturbance, poor appetite and weight loss

A

TCA

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17
Q

AE: TCA

A

anticholinergic - dry mouth
alpha blockade - orthostatic hypotension
histamine blockade - weight gain and excessive sweating

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18
Q

TCA used for OCD

A

Clopiramine

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19
Q

MOA: SSRI

A

inhibits neuronal reuptake of serotonin by inhibiting Serotonin Transporter (SERT)

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20
Q

DOC for Major Depressive Disorder

A

SSRIs

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21
Q

SSRI for OCD

A

Fluvoxamine

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22
Q

Discontinuation Syndrome is caused by which SSRIs

A

Paroxetine and Sertraline

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23
Q

Causes QT prolongation and cardiac septal defects (teratogen)

A

Citalopram

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24
Q

MOA: SNRIs

A

inhibits neuronal reuptake of serotonin and NEP by binding to transporters for 5HT and NE

25
Q

AD that can be used for fibromyalgia and diabetic neuropathy

26
Q

Serotonin Antagonist that can also be used for Hypnosis/sleeping aid

27
Q

AE of TRAZODONE

28
Q

AE of NEFAZODONE

A

Hepatotoxicity

29
Q

MOA: Serotonin Antagonist

A

Blocks 5HT2A receptors, weak inhibitor of NE and 5HT transporters

Nefazodone - also blocks serotonin reuptake

Trazodone - can also block 5HT2C receptors

30
Q

MOA: Strong NEP reuptake inhibitor

A

Amoxapine and Maprotiline

strong NEP reuptake inhibitor and weak serotonin reuptake inhibitor

blocks Dopamine D2 receptors

31
Q

AE: Amoxapine and Maprotiline

A

Parkinsonism

- due to dopamine receptor blockade

32
Q

MOA: Mirtazapine

A

increases amine release from nerve endings by antagonism of presynaptic alpha 2 adrenoceptors

blocks serotonin 5HT2 receptors

33
Q

AD that can be used for appetite stimulation

A

Mirtazapine

34
Q

AE: MIRTAZAPINE

A

Weight gain

Marked sedation

35
Q

UNICYCLIC AMINOKETONE

36
Q

MOA: BUPROPION

A

inhibits neuronal reuptake of dopamine and NEP

no effect on 5HT or NEP receptors or amine transporters

37
Q

AD that can be used in smoking cessation and alcohol dependence

38
Q

MOA: MAO inhibitors

A

inhibits MAO A and B

increase CNS levels of NE and 5HT

39
Q

Nonselective MAOi

A

Tranylcypromine

40
Q

MAOi B selective inhibitor

A

Selegiline

41
Q

may interfere with clonidine

42
Q

With high risk of serotonin syndrome if coadministered with MAOi

43
Q

SSRI development for treatment of premature ejaculation taken 1-3 hours prior to coitus

A

DAPOXETINE

44
Q

AD with increased risk for suicide in children and adolescents

45
Q

ADs not associated with sexual dysfunction

A

Mirtazapine
Bupropion
Nefazodone

46
Q

Causes Hypertensive crisis when take with Tyramine in avocado, cheese or wine

47
Q

Releasers of NEP from presynaptic vesicles

A

EAT

Ephedrine
Amphetamine
Tyramine

48
Q

Precipitating drug of Malignant Hyperthermia

A

Halothane, Succinylcholine

49
Q

Mechanism of Malignant Hyperthermia

A

massive Calcium release form SR

50
Q

Differentiate manifestations of Malignant Hyperthermia vs Serotonin Syndrome

A

Malignant Hyperthermia
FAT CHR
Fever, Acidosis, Trismus
Clonus, HTN, Rhabdomyolysis

Serotonin Syndrome
FAT CHD
Fever, Agitation, Tremor
Clonus, Hyperreflexia, Diaphoresis

51
Q

Treatement for Malignant Hyperthermia

A

Dantrolene

52
Q

Treatment Serotonin Syndrome

A

Sedation, Paralysis, Intubation, Ventilation, Cooling, Cyproheptadine, Chlorpromazine

53
Q

Manifestations of Neuroleptic Malignant Syndrome

A

FEVER

Fever
Encephalopathy
Vitals unstable
Elevated CPK
Rigidity
54
Q

Mechanism Neuroleptic Malignant Syndrome

A

Dopamine antagonism

55
Q

Precipitant of Neuroleptic Malignant Syndrome

A

Antipsychotics

56
Q

Treatment Neuroleptic Malignant Syndrome

A

Diphenhydramine

cooling, dantrolene, bromocriptine, amantadine, diazepam

57
Q

Drugs causing PRIAPISM

A 
Trazodone
Papaverine
Sildenafil
Quetiapine
Alprostadil
Warfarin
Bupropion
58
Q

Drugs causing erectile dysfunction

A

SSRI
OPIATES
RISPERIDONE
ETHANOL, ESTROGEN

PROPANOLOL
SPIRONOLACTONE
FINASTERIDE
HYDROCHLOROTHIAZIDE

PHARMA (15 decks)

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