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ANTIDEPRESSANTS Flashcards

1
Q

ANTIDEPRESSANTS

A 
Tricyclic AD
SSRI
SNRI
Serotonin Receptor Antagonists
Heterocyclic AD
MAO Inhibitors
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2
Q

TRICYCLIC ANTIDEPRESSANT

A 
Imipramine
Clomipramine
Desipramine
Amitryptyline
Nortryptiline
Doxepin
Protriptyline
Trimipramine
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3
Q

SSRI

A 
Fluoxetine
Paroxetine
Citalopram
Escitalopram
Sertraline
Fluvoxamine
Vilazodone
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4
Q

SNRI

A

Venlafaxine
Duloxetine
Desvenlafaxine
Milnacipran

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5
Q

Serotonin Antagonist

A

Trazodone
Nefazodone
Vortioxetine

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6
Q

TETRACYCLIC ANTIDEPRESSANT

A

Amoxapine
Maprotiline

Mirtazapine

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7
Q

UNICYCLIC AMINOKETONE

A

Bupropion

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8
Q

MAO INHIBITORS

A

Phenelzine
Tranylcypromine
Isocarboxazid
Selegiline

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9
Q

3Cs of TCA Overdose

A

Coma
Convulsions
Cardiotoxicity

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10
Q

Toxic dose of Tricyclic Antidepressant

A

7mg/kg

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11
Q

Lethal dose of Tricyclic Antidepressant

A

15mg/kg

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12
Q

What would you give to reverse cardiotoxicity due to tricyclic antidepressant overdose?

QRS duration>100 msec or ventricular arrhythmias

A

Bicarbonate

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13
Q

Drugs that can cause Serotonin Syndrome

A 
MAOi
TCA
Dextromethorphan
Meperidine
St. John's Wort
MDMA (ecstasy)
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14
Q

Manifestation of Serotonin Syndrome

A

FAT CHD

Fever Agitation Tremor

Clonus Hyperreflexia Diaphoresis

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15
Q

MOA: TCA

A

blocks NE and 5-HT transporters (prevents reuptake)

plus

blockade of ANS and histamine receptors

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16
Q

very useful for patients with psychomotor retardation, sleep disturbance, poor appetite and weight loss

A

TCA

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17
Q

AE: TCA

A

anticholinergic - dry mouth
alpha blockade - orthostatic hypotension
histamine blockade - weight gain and excessive sweating

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18
Q

TCA used for OCD

A

Clopiramine

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19
Q

MOA: SSRI

A

inhibits neuronal reuptake of serotonin by inhibiting Serotonin Transporter (SERT)

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20
Q

DOC for Major Depressive Disorder

A

SSRIs

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21
Q

SSRI for OCD

A

Fluvoxamine

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22
Q

Discontinuation Syndrome is caused by which SSRIs

A

Paroxetine and Sertraline

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23
Q

Causes QT prolongation and cardiac septal defects (teratogen)

A

Citalopram

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24
Q

MOA: SNRIs

A

inhibits neuronal reuptake of serotonin and NEP by binding to transporters for 5HT and NE

25
AD that can be used for fibromyalgia and diabetic neuropathy
SNRIs
26
Serotonin Antagonist that can also be used for Hypnosis/sleeping aid
Trazodone
27
AE of TRAZODONE
PRIAPISM
28
AE of NEFAZODONE
Hepatotoxicity
29
MOA: Serotonin Antagonist
Blocks 5HT2A receptors, weak inhibitor of NE and 5HT transporters Nefazodone - also blocks serotonin reuptake Trazodone - can also block 5HT2C receptors
30
MOA: Strong NEP reuptake inhibitor
Amoxapine and Maprotiline strong NEP reuptake inhibitor and weak serotonin reuptake inhibitor blocks Dopamine D2 receptors
31
AE: Amoxapine and Maprotiline
Parkinsonism | - due to dopamine receptor blockade
32
MOA: Mirtazapine
increases amine release from nerve endings by antagonism of presynaptic alpha 2 adrenoceptors blocks serotonin 5HT2 receptors
33
AD that can be used for appetite stimulation
Mirtazapine
34
AE: MIRTAZAPINE
Weight gain | Marked sedation
35
UNICYCLIC AMINOKETONE
BUPROPION
36
MOA: BUPROPION
inhibits neuronal reuptake of dopamine and NEP no effect on 5HT or NEP receptors or amine transporters
37
AD that can be used in smoking cessation and alcohol dependence
BUPROPION
38
MOA: MAO inhibitors
inhibits MAO A and B | increase CNS levels of NE and 5HT
39
Nonselective MAOi
Tranylcypromine
40
MAOi B selective inhibitor
Selegiline
41
may interfere with clonidine
TCA
42
With high risk of serotonin syndrome if coadministered with MAOi
TCA
43
SSRI development for treatment of premature ejaculation taken 1-3 hours prior to coitus
DAPOXETINE
44
AD with increased risk for suicide in children and adolescents
SNRI
45
ADs not associated with sexual dysfunction
Mirtazapine Bupropion Nefazodone
46
Causes Hypertensive crisis when take with Tyramine in avocado, cheese or wine
TCAs
47
Releasers of NEP from presynaptic vesicles
EAT Ephedrine Amphetamine Tyramine
48
Precipitating drug of Malignant Hyperthermia
Halothane, Succinylcholine
49
Mechanism of Malignant Hyperthermia
massive Calcium release form SR
50
Differentiate manifestations of Malignant Hyperthermia vs Serotonin Syndrome
Malignant Hyperthermia FAT CHR Fever, Acidosis, Trismus Clonus, HTN, Rhabdomyolysis Serotonin Syndrome FAT CHD Fever, Agitation, Tremor Clonus, Hyperreflexia, Diaphoresis
51
Treatement for Malignant Hyperthermia
Dantrolene
52
Treatment Serotonin Syndrome
Sedation, Paralysis, Intubation, Ventilation, Cooling, Cyproheptadine, Chlorpromazine
53
Manifestations of Neuroleptic Malignant Syndrome
FEVER ``` Fever Encephalopathy Vitals unstable Elevated CPK Rigidity ```
54
Mechanism Neuroleptic Malignant Syndrome
Dopamine antagonism
55
Precipitant of Neuroleptic Malignant Syndrome
Antipsychotics
56
Treatment Neuroleptic Malignant Syndrome
Diphenhydramine cooling, dantrolene, bromocriptine, amantadine, diazepam
57
Drugs causing PRIAPISM
``` Trazodone Papaverine Sildenafil Quetiapine Alprostadil Warfarin Bupropion ```
58
Drugs causing erectile dysfunction
SSRI OPIATES RISPERIDONE ETHANOL, ESTROGEN PROPANOLOL SPIRONOLACTONE FINASTERIDE HYDROCHLOROTHIAZIDE

PHARMA (15 decks)

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