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PHARMA > Gonadal Hormones and Inhibitors > Flashcards

Gonadal Hormones and Inhibitors Flashcards

1
Q

Androgen Receptor Antagonist

A

Flutamide, Bicalutamide, Nilutamide

Cyproterone, Cyproterone Acetate

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2
Q

Androgen Synthesis Inhibitor/5-Alpha Reductase Inhibitor

A

Finasteride

Dutasteride

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3
Q

MOA: FINASTERIDE

A

inhibits 5 alpha reductase enzyme that converts testosterone to DHT (most potent form)

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4
Q

Anabolic Steroids

A

Oxandrolone, Nandrolone Decanoate

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5
Q

Used in male hypogonadism

A

Androgens - Testosterone, Methyltestosterone, Testosterone Cypionate, Oxymetholone, Mesterolone

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6
Q

Used in illegal performance enhancement by athletes

A

Anabolic Steroids

oxandrolone, nandrolone decanoate

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7
Q

Used in Prostate CA

A

Flutamide, Bicalutamide, Nilutamide

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8
Q

Used in hirsutism

A

Cyproterone, Cyproterone acetate

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9
Q

Used in BPH

A

Finasteride, Dutasteride

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10
Q

SERM

A

Tamoxifen
Toremifene
Raloxifene
Clomiphene

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11
Q

Aromatase Inhibitors

A

Anstrozole
Letrozole
Exemestane

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12
Q

Ovarian Inhibitor (Anti-Androgen)

A

Danazol

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13
Q

GNRH AGONISTS

A 
Leuprolide
Gonadorelin
Goserelin
Histrelin
Nafarelin
Triptorelin
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14
Q

GNRH ANTAGONISTS

A

Ganirelix
Cetrorelix
Abarelix
Degarelix

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15
Q

Glucocorticoid and Progesterone Receptor Antagonist

A

Mifepristone

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16
Q

Use: Tamoxifen, Toremifene

A

Hormone-responsive Breast Cancer

ER+ PR+

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17
Q

Use: Raloxifene

A

Osteoporosis

preferred
increases bone mineral density without estrogenic effects on endometrial tissue

18
Q

Use: Clomiphene

A

Induction of ovulation

antagonizes estrogen receptors in the pituitary thus inhibiting the negative feedback by estrogen = increase LH and FSH

19
Q

Enzyme that converts Testosterone to Estrogen (Estradiol)

A

Aromatase

20
Q

Irreversible aromatase inhibitor

A

Exemestane

21
Q

Pharmacologic antagonist of glucocorticoid and progesterone receptors used in medical abortion

A

Mifepristone

22
Q

AE of Tamoxifen

A

Increased risk for endometrial hyperplasia, endometrial CA, DVT

23
Q

AE of Raloxifene

A

Increased risk for DVT

24
Q

Side effect of Clomiphene

A

Multiple pregnancies (10%)

Increased risk of low-grade ovarian cancer with long term use

25
Q

Full Estrogen receptor antagonist

A

FLUVESTRANT

26
Q

Intermittent GnRH agonists will result to

A

increased FSH AND LH secretion

27
Q

Prolonged continuous administration of GnRH Agonists will result to

A

reduced LH and FSH secretion due to downregulation of GnRH receptors

28
Q

What should be given with GnRH agonists to prevent temporary exacerbation in treating prostate CA?

A

Flutamide

29
Q

Uses: GnRH Agonists

A

Ovarian Suppression
Controlled ovarian hyperstimulation
Advanced Prostate CA

30
Q

MOA: Danazol

A

Weak CYP450 inhibitor

Partial agonists of progestin and androgen receptors

31
Q

Use: Danazol

A

Endometriosis

Fibrocystic Disease

Hemophilia

Angioneurotic edema

32
Q

Emergency contraception

A

Levonorgestrel

Ethinyl Estradiol + Levonorgestrel

33
Q

Emergency contraception must be taken within ?

A

72 hours

34
Q

Progestin-only Contraceptive

A

Medroxy-Progesterone Acetate

35
Q

Absolute Contraindications to OCPs

A 
>35y who smokes >15 sticks per day
with IHD or multiple CVD risk factors
with previous stroke hx
complicated VHD
complicated solid organ transplantation
HTN
SLE
Cirrhosis, hepatic adenoma or hepatoma
Pregnancy and early postpartum (<12d)
undiagnosed AUB
36
Q

Relative Risk to OCP

A

Hypertension controlled
Taking anticonvulsants
Post bariatic surgery

37
Q

PROGESTINS

A 
norgestrel
norethindrone
ethynodiol
megestrol
desogestrel
norelgestromin
norgestimate
etonogestrel
progesterone
LEVONORGESTREL
dydrogesterone
ulipristal
tibolone
norethisterone
dienogest
38
Q

Progestin used as an appetite stimulant

A

Megestrol

39
Q

a synthetic steroid with weak estrogrenic, progestogenic and androgenic effect used in menopausal hormone therapy, postmenopausal osteoporosis and endometriosis

A

TIBOLONE

40
Q

Use: Progestins

A

HRT, contraception, assisted reproduction, anovulation induction

41
Q

Synthetic estrogen associated with Clear Cell vaginal adenocarcinoma

A

DES or Diethylstilbestrol

42
Q

ESTROGENS

A 
Ethinyl Estradiol
Mestranol
Estradiol Cypionate
Premarin
Estriol

PHARMA (15 decks)

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