Corticosteroids and Antagonists

Question 1

Glucocorticoid with the highest anti-inflammatory potency

Answer 1

Betamethasone

Question 2

Mineralocorticoid with the highest salt-retaining potency

Answer 2

Fludrocortisone

Question 3

Used for fetal lung maturation

Answer 3

Betamethasone and Dexamethasone

Question 4

Glucocorticoid Synthesis Inhibitors

Answer 4

Desmolase Inhibitor - Aminoglutethimide
CYP450 Inhibitor - Ketoconazole
11B Hydroxylase Inhibitor - Metyrapone

Question 5

Glucocorticoid Antagonist

Answer 5

Mifepristone

Question 6

reduces synthesis of all hormonally active steroids

Answer 6

Aminoglutethimide

Question 7

Inhibits cholesterol-side chain cleavage, CYP450 enzymes

Answer 7

Ketoconazole

Question 8

alternative to ketoconazole

Answer 8

itraconazole

Question 9

selective inhibitor of steroid 11-hydroxylation, interfering with cortisol and corticosterone synthesis

Answer 9

Metyrapone

Question 10

Drug of choice for pregnant with Cushing’s Syndrome

Answer 10

Metyrapone

Question 11

Competitive inhibitor at the GC receptor as well as progesterone receptor

Answer 11

Mifepristone

Question 12

Side Effects of Corticosteroids

Answer 12

CUSHINGOID

Cataract
Ulcers
Striae
Hypertension, Hirsutism
Immunosuppression, Infection
Necrosis of the femoral head
Glucose elevation
Osteoporosis, Obesity
Impaired wound healing
DM

Question 13

Long Acting Glucocorticoids

Answer 13

Betamethasone, Dexamethasone

Question 14

Short Acting Glucocorticoids

Answer 14

Hydrocortisone/cortisol
Desonide
Fluticasone
Mometasone
Desoximetasone
Clobetasol

Question 15

Mineralocorticoid Agonist

Answer 15

Fludrocortisone, Deoxycorticosterone

Question 16

Mineralocorticoid Antagonist

Answer 16

Spironolactone

Question 17

MOA: Fludrocortisone and Deoxycorticosterone

Answer 17

strong agonist of mineralocorticoid receptors + moderate activation of glucocorticoid receptors

Question 18

MOA: spironolactone

Answer 18

Block aldosterone receptors