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PHARMA > ANTIPSYCHOTIC AGENTS AND LITHIUM > Flashcards

ANTIPSYCHOTIC AGENTS AND LITHIUM Flashcards

1
Q

caused by a relative excess of dopamine in the mesolimbic-mesocortical pathway

A

Schizophrenia

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2
Q

Positivr symptoms

A 
HIDES
Hallucination
Illusion
Delusion
Excitement
Suspciousness
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3
Q

Negative Signs

A

Anhedonia
Avolition
Anergia

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4
Q

D1 receptor family?

D2 receptor family?

A

D1 fam - D1, 4, 5

D2 fam - D2, 3

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5
Q

addresses more of the positive symptoms

A

TYPICAL ANTIPSYCHOTICS

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6
Q

addresses both positive and negative symptoms

A

ATYPICAL ANTIPSYCHOTICS

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7
Q

higher chances of causing EPS

A

high potency typical antipsychotics

- haloperidol, droperidol

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8
Q

more likely to cause sedatiom and postural hypotension due to alpha receptor blockade

A

Low Potency Typical Antipsychotics

- thioridazine, chlorpromazine

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9
Q

with higher propensity to cause metabolic derangements (weight gain, endocrine problems)

A

Atypical antipsychotics

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10
Q

Blocks more D2 receptors than 5HT2A

A

Typical Antipsychotics

Atypical - blocks more 5HT2A receptors

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11
Q

TYPICAL ANTIPSYCHOTICS

A

PHENOTHIAZINES
PIPERIDINES
BUTYROPHENONE

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12
Q

PHENOTHIAZINES

A

Chlorpromazine
Levomepromazine
Prochlorperazine
Promethazine

Thiothexene
Flupentixol

Thioridazine
Fluphenazine
Perphenazine
Trifluoperazine

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13
Q

AE: RETINAL DEPOSITS

A

thioridazine

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14
Q

Phenothiazine with the most muscarinic blockade therefore has the least EPS amongst typical antipsychotics

A

Thioridazine

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15
Q

phenothiazine with quinidine like actions (prolongation of QT interval)

A

Thioridazine

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16
Q

Phenothiazine with significant Parkinson-like effect

A

Fluphenazine and Trifluoroperazine

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17
Q

BUTYROPHENONE

A

Haloperidol

Droperidol

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18
Q

USE: BUTYROPHENONE

A

Schizophrenia
BPD - manic phase
Huntington’s Disease
Tourette’s Syndrome

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19
Q

major tranquilizer with highest potential for EPS and neuroleptic malignant syndrome

A

Haloperidol

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20
Q

least sedating among typical antipsychotics

A

Haloperidol

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21
Q

ATYPICAL ANTIPSYCHOTICS

A 
DIBENZODIAZEPINE
THIENOBENZODIAZEPINE
DIBENZOTHIAZEPINE
BENZISOXAZOLE
DIHYDROINDOLONE
DIHYDROCARBOSTYRIL
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22
Q

DIBENZODIAZEPINE

A

CLOZAPINE

23
Q

THIENOBENZODIAZEPINE

A

OLANZAPINE

24
Q

DIBENZOTHIAZEPINE

A

QUETIAPINE

25
Q

BENZISOXAZOLE

A

RISPERIDONE

PALIPERIDONE

26
Q

DIHYDROINDOLONE

A

ZIPRASIDONE

27
Q

DIHYDROCARBOSTYRIL

A

ARIPIPRAZOLE

28
Q

DOC for refractory and suicidal schizo

A

Clozapine

29
Q

With the highest tendency to cause weight gain among atypical

A

Clozapine, Olanzapine

30
Q

Only antipsychotic that reduces the risk of suicide

A

Clozapine

31
Q

Most feared complications of clozapine

A

Agranulocytosis and seizures

32
Q

Clozapine is not associated with seizure because?

A

it blocks the D2C receptors (mesocortical mesolimbic area) not the D2A (nigrostriatal pathway)

D4=a1>5HT2A>D2=D1

33
Q

causes minimal or no increase in prolactin and has reduced risk of EPS (MINIMAL D2 antagonism)

A

Olanzapine, Quetiapine, Aripiprazole

34
Q

atypicals least likely to cause tardive dyskinesia

A

Quetiapine and Clozapine

35
Q

atypical that causes somnolence, sleep paralysis, hypnagogic hallucinations, cataracts, priapism and QT prolongation

A

Quetiapine

36
Q

atypical with the highest propensity to cause hyperprolactinemia (amenorrhea, galactorrhea)

A

Risperidone

37
Q

only antipsychotic approved for schizophrenia in the youth

A

Risperidone

38
Q

atypical causing marked QT prolongation

A

Ziprasidone

39
Q

atypical - partial agonist at the D2 receptor

A

Aripiprazole

40
Q

Least sedating atypical

A

Aripiprazole

41
Q

Safe in pregnancy - atypical

A

Olanzapine and quetiapine

42
Q

No atropine-like effects - atypical

A

Aripiprazole, Ziprasidone

43
Q

QT prolongation - atypical

A

Ziprasidone, Quetiapine

44
Q

Atypical can also be used in anorexia nervosa and depression

A

Olanzapine

45
Q

Atypical can also be used in sleep promotion and maintenance

A

Quetiapine

46
Q

Atypical can also be used in depression, intractable hiccups, tourette syndrome

A

Risperidone, Paliperidone

47
Q

Atypical can also be used in MDD, autism, cocaine, dependence

A

Aripiprazole

48
Q

MOOD STABILIZER

A

LITHIUM

49
Q

DOC FOR BIPOLAR DISORDER

A

LITHIUM

50
Q

most common side effect of lithium

A

tremor

51
Q

lithium is contraindicated in

A

sick sinus syndrome or brady tachy syndrome

52
Q

AE of LITHIUM

A

LiTHIUM

Low Thyroid hormone
Heart - Ebstein Anomaly
Insipidus - nephrogenic
Unintentional Movement (Tremor)

53
Q

Threshold for toxicity

A

2meq/L

54
Q

Treatment for Lithium Overdose

A

Hemodialysis

Manifestation
brady, hypotension
agitation, tremor, twitching

PHARMA (15 decks)

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