Cancer Chemotherapy

Question 1

Drugs that can cause Pulmonary Fibrosis

Answer 1

Blue Buses Are Banned in North Metro.

Bleomycin
Busulfan
Amiodarone
Bromocriptine
Nitrofurantoin
Methotrexate

Question 2

Rescue therapy for Doxorubicin

Answer 2

Dexrazoxane

Question 3

Rescue drug for Cisplatin

Answer 3

Amifostine

Question 4

Rescue Drug for Cyclophosphamide

Answer 4

MESNA

Question 5

Rescue Drug for Methotrexate

Answer 5

Leucoverin

Question 6

CANCER DRUGS

Answer 6

Alkylating Agents
Anti-metabolites
Natural Products
Antitumor Antibiotics
Miscellaneous
Hormonal

Question 7

MOA: Alkylating Agents

Answer 7

inserted in the DNA of cancer cells

causing chain termination because the cancer cell will lack 3’OH

will cause BM suppression

Question 8

Which of the following alkylating agents has the highest carcinogenic potential?

Answer 8

Procarbazine

Question 9

Which of the following alkylating agents is designed for brain tumors?

Answer 9

Nitrosureas - carmustine, bendamustine, lomustine

Question 10

Most common leukemia in adults with Smudge cells?

Answer 10

CLL

Question 11

The MOA of these alkylating agents is to form hydrogen peroxide that generates free radicals causing DNA strand scission?

Answer 11

PROCARBAZINE, DACARBAZINE

Question 12

ALKYLATING AGENTS

Answer 12

cyclophosphamide, ifosfamide, chlorambucil, meclorethamine

cisplatin, carboplatin, oxiplatin

procarbazine, dacarbazine

busulfan

carmustine, lomustine, bendamustine (nitrosureas)

Question 13

ANTIMETABOLITES

Answer 13

DMARDS
PURINE
PYRIMIDINE

Question 14

DMARD

Answer 14

METHOTREXATE

Question 15

PURINES

Answer 15

6 Mercaptopurine, Thioguanine, Azathioprine

Pemetrexed

Question 16

PYRIMIDINE

Answer 16

5FU

CYTARABINE

GEMCITABINE
CAPECITABINE

Question 17

MOA: ANTIMETABOLITES

Answer 17

mimic purines and pyrimidines

inserted in the DNA

causes chain termination leading to

eventual cessation of cancer cell growth

Question 18

inhibits ribonucleotide reductase with reduced formation of dNTPs

Answer 18

CYTARABINE, GEMCITABINE, CAPECITABINE

Question 19

Antimetabolite used for ChorioCA

Answer 19

Methotrexate

Question 20

Antimetabolite used for mesothelioma

Answer 20

Pemetrexed

Question 21

Antimetabolite used for Pancreatic Cancer

Answer 21

Gemcitabine, Capecitabine

Question 22

Antimetabolite used for Breast, Colorectal, Head and Neck Cancer

Answer 22

5-Fluorouracil

Question 23

Antimetabolite used in AML, ALL, CML in blast crisis

Answer 23

Cytarabine

Question 24

NATURAL PRODUCTS OF ANTICANCER DRUGS

Answer 24

VINCA ALKALOID
PODOPHYLLOTOXIN
CAMPTOTHECIN
TAXANE

Question 25

VINCA ALKALOIDS

Answer 25

VINCRISTINE VINBLASTINE VINORELBINE

Question 26

PODOPHYLLOTOXIN

Answer 26

ETOPOSIDE | TENIPOSIDE

Question 27

CAMPTOTHECIN

Answer 27

TOPOTECAN | IRINOTECAN

Question 28

TAXANE

Answer 28

PACLITAXEL DOCETAXEL CABAZITAXEL

Question 29

MOA: VINCA ALKALOIDS

Answer 29

prevents microtubule assembly cell arrest at metaphase

Question 30

MOA: PODOPHYLLOTOXINS

Answer 30

inhibits DNA topoisomerase II (DNA Gyrase) inhibits mitochondrial electron transport

Question 31

MOA: CAMPTOTHECIN

Answer 31

inhibits topoisomerase I

Question 32

MOA: TAXANES

Answer 32

interferes with mitotic spindle prevents microtubule disassembly into tubulin monomers

Question 33

Natural product of anticancer drugs used for advanced breast cancer

Answer 33

Taxanes

Question 34

ANTITUMOR ANTIBIOTICS

Answer 34

Anthracyclines - Doxorubicin, Daunoribicin, Idarubicin, Epirubicin, Mitoxantrone Abx - Bleomycin, Mitomycin, Actinomycin D (Dactinomycin)

Question 35

Only vitamin that can cure cancer

Answer 35

All-Trans Retinoic Acid (Vitamin A)

Question 36

Patient developed dyspnea, fever, weight gain and peripheral edema after being given a vitamin A derivative. What will you give to the patient?

Answer 36

Retinoic Syndrome - dexamthasone

Question 37

All-Trans Retinoic Acid is a vitamin A derivative used to treat what type of cancer?

Answer 37

Acute Promyelocytic Leukemia

Question 38

Trastuzumab, Pertuzumab, Lapatinib are monoclonal ab used in treatment of

Answer 38

Metastatic Breast CA Her2/NEU positive

Question 39

MOA: ASPARAGINASE

Answer 39

hydrolyzes circulating L-asparaginase > > rapid inhibition of protein synthesis

Question 40

Asparaginase is used in the treatment of

Answer 40

Acute Lymphoblastic Leukemia

Question 41

Monoclonal antibody used in the treatment of NHL (low grade)

Answer 41

RITUXIMAB

Question 42

MOA: BEVACIZUMAB

Answer 42

inhibits binding of VEGF to VEGFR leading to inhibition of VEGF signaling (inhibits angiogenesis)