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PHARMA > Cancer Chemotherapy > Flashcards

Cancer Chemotherapy Flashcards

1
Q

Drugs that can cause Pulmonary Fibrosis

A

Blue Buses Are Banned in North Metro.

Bleomycin
Busulfan
Amiodarone
Bromocriptine
Nitrofurantoin
Methotrexate
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2
Q

Rescue therapy for Doxorubicin

A

Dexrazoxane

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3
Q

Rescue drug for Cisplatin

A

Amifostine

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4
Q

Rescue Drug for Cyclophosphamide

A

MESNA

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5
Q

Rescue Drug for Methotrexate

A

Leucoverin

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6
Q

CANCER DRUGS

A 
Alkylating Agents
Anti-metabolites
Natural Products
Antitumor Antibiotics
Miscellaneous
Hormonal
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7
Q

MOA: Alkylating Agents

A

inserted in the DNA of cancer cells

causing chain termination because the cancer cell will lack 3’OH

will cause BM suppression

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8
Q

Which of the following alkylating agents has the highest carcinogenic potential?

A

Procarbazine

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9
Q

Which of the following alkylating agents is designed for brain tumors?

A

Nitrosureas - carmustine, bendamustine, lomustine

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10
Q

Most common leukemia in adults with Smudge cells?

A

CLL

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11
Q

The MOA of these alkylating agents is to form hydrogen peroxide that generates free radicals causing DNA strand scission?

A

PROCARBAZINE, DACARBAZINE

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12
Q

ALKYLATING AGENTS

A

cyclophosphamide, ifosfamide, chlorambucil, meclorethamine

cisplatin, carboplatin, oxiplatin

procarbazine, dacarbazine

busulfan

carmustine, lomustine, bendamustine (nitrosureas)

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13
Q

ANTIMETABOLITES

A

DMARDS
PURINE
PYRIMIDINE

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14
Q

DMARD

A

METHOTREXATE

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15
Q

PURINES

A

6 Mercaptopurine, Thioguanine, Azathioprine

Pemetrexed

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16
Q

PYRIMIDINE

A

5FU

CYTARABINE

GEMCITABINE
CAPECITABINE

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17
Q

MOA: ANTIMETABOLITES

A

mimic purines and pyrimidines

inserted in the DNA

causes chain termination leading to

eventual cessation of cancer cell growth

18
Q

inhibits ribonucleotide reductase with reduced formation of dNTPs

A

CYTARABINE, GEMCITABINE, CAPECITABINE

19
Q

Antimetabolite used for ChorioCA

A

Methotrexate

20
Q

Antimetabolite used for mesothelioma

A

Pemetrexed

21
Q

Antimetabolite used for Pancreatic Cancer

A

Gemcitabine, Capecitabine

22
Q

Antimetabolite used for Breast, Colorectal, Head and Neck Cancer

A

5-Fluorouracil

23
Q

Antimetabolite used in AML, ALL, CML in blast crisis

A

Cytarabine

24
Q

NATURAL PRODUCTS OF ANTICANCER DRUGS

A

VINCA ALKALOID
PODOPHYLLOTOXIN
CAMPTOTHECIN
TAXANE

25
Q

VINCA ALKALOIDS

A

VINCRISTINE
VINBLASTINE
VINORELBINE

26
Q

PODOPHYLLOTOXIN

A

ETOPOSIDE

TENIPOSIDE

27
Q

CAMPTOTHECIN

A

TOPOTECAN

IRINOTECAN

28
Q

TAXANE

A

PACLITAXEL
DOCETAXEL
CABAZITAXEL

29
Q

MOA: VINCA ALKALOIDS

A

prevents microtubule assembly

cell arrest at metaphase

30
Q

MOA: PODOPHYLLOTOXINS

A

inhibits DNA topoisomerase II (DNA Gyrase)

inhibits mitochondrial electron transport

31
Q

MOA: CAMPTOTHECIN

A

inhibits topoisomerase I

32
Q

MOA: TAXANES

A

interferes with mitotic spindle

prevents microtubule disassembly into tubulin monomers

33
Q

Natural product of anticancer drugs used for advanced breast cancer

34
Q

ANTITUMOR ANTIBIOTICS

A

Anthracyclines - Doxorubicin, Daunoribicin, Idarubicin, Epirubicin, Mitoxantrone

Abx - Bleomycin, Mitomycin, Actinomycin D (Dactinomycin)

35
Q

Only vitamin that can cure cancer

A

All-Trans Retinoic Acid (Vitamin A)

36
Q

Patient developed dyspnea, fever, weight gain and peripheral edema after being given a vitamin A derivative. What will you give to the patient?

A

Retinoic Syndrome - dexamthasone

37
Q

All-Trans Retinoic Acid is a vitamin A derivative used to treat what type of cancer?

A

Acute Promyelocytic Leukemia

38
Q

Trastuzumab, Pertuzumab, Lapatinib are monoclonal ab used in treatment of

A

Metastatic Breast CA

Her2/NEU positive

39
Q

MOA: ASPARAGINASE

A

hydrolyzes circulating L-asparaginase > > rapid inhibition of protein synthesis

40
Q

Asparaginase is used in the treatment of

A

Acute Lymphoblastic Leukemia

41
Q

Monoclonal antibody used in the treatment of NHL (low grade)

42
Q

MOA: BEVACIZUMAB

A

inhibits binding of VEGF to VEGFR leading to inhibition of VEGF signaling

(inhibits angiogenesis)

PHARMA (15 decks)

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