BASIC PRINCIPLES Flashcards

1
Q

PHASE 1 METABOLISM

A

Biotransformation/ Functionalization

H. O. R. D.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

H. O. R. D.

A

Hydrolysis
Oxidation
Reduction
Deamination

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

PHASE 2 METABOLISM

A

Synthesis/ Conjugation

Conjugated with GAGGS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

G.A.G.G.S.

A
Glucoronic Acid
Acetic Acid
Gluthatione
Glycine
Sulfate/Methyl Group
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

ENZYME INDUCERS

A

Ethel Booba takes Phen-Phen and Refuses Greasy Carb Shakes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Ethel Booba takes Phen-Phen and Refuses Greasy Carb Shakes

A
Ethanol
Barbiturates except secobarbital
Phenytoin
Rifampicin
Griseofulvin
Carbmazine
St. John's Wort/Smoking
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

ENZYME INHIBITORS

A

Inhibitors Stop Cyber Kids from Eating GRApefruit QV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Inhibitors Stop Cyber Kids from Eating GRApefruit QV

A
Isoniazid
Sulfonamides
Cimetidine
Ketoconazole
Erythromycin
Grapefruit juice
Ritonavir
Amiodarone
Quinidine
Valproic Acid

Many others

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Zero Order Kinetics Drugs

A

WHAT PET

Warfarin
Heparin
Aspirin
Tolbutamide
Phenytoin
Ethanol
Theophylline
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

STEADY STATE CONCENTRATION

1st, 2nd, 3rd, 4th

A

1 - 50%
2 - 75%
3 - 83.5%
4 - 93.75%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What drugs display tachyphylaxis?

A

MED students Love to watch CNN in HD.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

MED students Love to watch CNN in HD.

A
Metoclopramide
Ephedrine
Dobutamine
LSD
Calcitonin
Nitroglycerin
Nicotine
Hydralazine
Desmopressin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

TERATOGENIC EFFECT

THALIDOMIDE

A

Phocomelia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

TERATOGENIC EFFECT

PHENYTOIN

A

Fetal Hydantoin Syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

TERATOGENIC EFFECT

LITHIUM

A

Ebstein Anomaly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

TERATOGENIC EFFECT

ANTI EPILEPTIC DRUGS

A

NTDS

17
Q

TERATOGENIC EFFECT

MISOPROSTOL

A

Mobius Sequence

18
Q

TERATOGENIC EFFECT

TETRACYCLINE

A

Tooth Discoloration

19
Q

TERATOGENIC EFFECT

STREPTOMYCIN

A

OTOTOXICITY

20
Q

TERATOGENIC EFFECT

METHIMAZOLE

A

Aplasia Cutis Congenita

21
Q

TERATOGENIC EFFECT

FLUOROQUINOLONES

A

Cartilage Damage

22
Q

TERATOGENIC EFFECT

SULFONAMIDES

A

Kernicterus

23
Q

TERATOGENIC EFFECT

WARFARIN FIRST TRIMESTER

A

Chondroplasia

24
Q

TERATOGENIC EFFECT

WARFARIN 2ND TRIMESTER

A

CNS MALFORMATIONS

25
Q

In vitro test for mutagenicity

A

Ames Test

26
Q

In vivo test for mutagenicity

A

Dominant Lethal Test