BASIC PRINCIPLES Flashcards
PHASE 1 METABOLISM
Biotransformation/ Functionalization
H. O. R. D.
H. O. R. D.
Hydrolysis
Oxidation
Reduction
Deamination
PHASE 2 METABOLISM
Synthesis/ Conjugation
Conjugated with GAGGS
G.A.G.G.S.
Glucoronic Acid Acetic Acid Gluthatione Glycine Sulfate/Methyl Group
ENZYME INDUCERS
Ethel Booba takes Phen-Phen and Refuses Greasy Carb Shakes
Ethel Booba takes Phen-Phen and Refuses Greasy Carb Shakes
Ethanol Barbiturates except secobarbital Phenytoin Rifampicin Griseofulvin Carbmazine St. John's Wort/Smoking
ENZYME INHIBITORS
Inhibitors Stop Cyber Kids from Eating GRApefruit QV
Inhibitors Stop Cyber Kids from Eating GRApefruit QV
Isoniazid Sulfonamides Cimetidine Ketoconazole Erythromycin Grapefruit juice Ritonavir Amiodarone Quinidine Valproic Acid
Many others
Zero Order Kinetics Drugs
WHAT PET
Warfarin Heparin Aspirin Tolbutamide Phenytoin Ethanol Theophylline
STEADY STATE CONCENTRATION
1st, 2nd, 3rd, 4th
1 - 50%
2 - 75%
3 - 83.5%
4 - 93.75%
What drugs display tachyphylaxis?
MED students Love to watch CNN in HD.
MED students Love to watch CNN in HD.
Metoclopramide Ephedrine Dobutamine LSD Calcitonin Nitroglycerin Nicotine Hydralazine Desmopressin
TERATOGENIC EFFECT
THALIDOMIDE
Phocomelia
TERATOGENIC EFFECT
PHENYTOIN
Fetal Hydantoin Syndrome
TERATOGENIC EFFECT
LITHIUM
Ebstein Anomaly