signal trans 3 part 2

Question 2

GPCR has – transmembrane alpha helixes

Answer 2

7

Question 3

tf the N terminal is on ext side and C terminal in on the int. side in GPCR.

Answer 3

T

Question 4

glycosylation ; phosphorylation in GPCR

Answer 4

N; C terminal in GPRC

Question 5

rhodopsin recptor

Answer 5

GPCR

Question 6

Largest subunit in gpcr

Answer 6

alpha

Question 7

phillic to phobic on gpcr

Answer 7

alpha; betay on gpcr

Question 8

Guanine nucleotide-binding site (GDP, GTP) and GTPase activity

Answer 8

alpha subunit of GPCR

Question 9

GPCR portion that interacs with effector protein

Answer 9

alpha subunit

Question 10

BY unit of GPCR

Answer 10

cov attach to membrane with some int. with effector protein

Question 11

after ligand bidns GPCR —- —–,

GDP/GTP exchange causes—– with —– to dissociate

Answer 11

conf change

alpha subunit with GTP

(GPCR)

Question 12

seconary enzyme in GPCR

Answer 12

will bing alpha subunit with GTP

and intrinsic GTPase activation cause Hydrolysis of GTP to GDP and release of alpha GDP

Question 14

major mechanism of desensitization of GPCR

Answer 14

Receptor phosphorylation by protein kinases

Question 15

Protein kinase A (PKA); receptor

GPCR-specific protein kinases (GRKs); receptor

Answer 15

+/- ligand GPCR-specific

+ ligand

Question 16

Extracellular enzymes —– or —- many of the small ligands.

Answer 16

Extracellular enzymes metabolize or inactivate many of the small ligands.

GPCR inact

Question 17

Answer 17

Extracellular enzymes metabolize or inactivate many of the small ligands.

Question 18

Answer 18

Receptor phosphorylation by protein kinases

GPCR termination

Question 19

—— —— endocytosis accounts for some desensitization

Answer 19

Receptor-mediated endocytosis accounts for some desensitization

GPCR inact.

Question 21

Effect of EToh on GABA bidning site

Answer 21

Causes membrane potential to become more negative

Increases GABA’s suppression of neural activity

Increases dopamine release

Question 23

Caffeinated Alcohol Drinks

—– Binds to allosteric binding site on GABA-bound receptor

Answer 23

ethanol

Question 24

TF in : Caffeinated Alcohol Drinks

EToh bidning to GABA receptor keeps it closed

Answer 24

F keeps it open

Question 26

GABA Ligand-Gated Ion Channel

Answer 26

Anion-Selective (Inhibitory)

Question 27

Adenosine G-Protein-Coupled Receptor thru caffiene stimulant

Answer 27

① Blocks adenosine binding site (antagonist)

Question 28

Normally Adenosine G-Protein-Coupled Receptor

Answer 28

Suppresses neural activity; increases blood flow

Question 29

RTK

Answer 29

Ligand binding Dimerization Kinase activation

then

Autophosphorylation of tyrosine residues (cross-phosphorylation)

Question 30

GF binding to RTK

Answer 30

act of RTK bidning of adaptor pro.

then

RAS act protein

Question 31

Allows increased neural activity Leads to blood vessel constriction, epinephrine release, and increased level of alertness

Answer 31

Caffiene blocking

Question 32

Individual feels sober when highly intoxicated.

Answer 32

end result of cafffiene alcohol drinks

Question 33

Each subunit is a single polypeptide chain consisting of: Large extracellular N-terminal domain for binding ligand Single transmembrane domain

Intracellular C-terminal domain with catalytic domains

Answer 33

Enzyme-Linked Receptor

Question 34

dimer; tetramer

Answer 34

RTK; SER threonine kinase

Question 35

effect of MAP Kinase – Effector Protein

Answer 35

Question 36

Receptor Serine/Threonine Kinase

Ligand binding to type –

Dimerization with type –

Kinase activation

and cross-phosphorylation (Ser/Thr residues) of type —

Answer 36

Ligand binding to type II

Dimerization with type I

Kinase activation

and cross-phosphorylation (Ser/Thr residues) of type I

Question 39

RAS GDP

Answer 39

attaches to membrane

and is converted to active RAS (GTP) upon act of RTK by GF

RAS act protein phos it.

Question 40

(serine/threonine kinase

Answer 40

MAP Kinase Kinase Kinase

MAP Kinase – Effector Protein

Question 41

clustering

adaptin binding

clathrin binding

Answer 41

adaptin binding

clathrin binding

clustering

Question 42

MAP Kinase Kinase Kinase

Answer 42

act by RASGTP

Question 43

threonine/tyrosine kinase)

Answer 43

MAP Kinase Kinase

Question 46

upon act of receptor Serine/Threonine Kinase

Answer 46

SMAD binding and

phosphorylation

SMAD unfolding

and act

Question 47

after act of SMAD

Answer 47

dissociation and dimerization with diff SMAD subtypes

translocate to nucleus to alter gene expression

Question 48

binding of act SMAD to another SMAD

Answer 48

Exposure of nuclear localization signal (NLS)

Question 49

Termination of Enzyme linked receptor

Answer 49

Receptor-Mediated Endocytosis (Down-Regulation)