signal trans 4 part 2 Flashcards
tf in cholera there is minimum loss of Na and water in intestines
F excessive
pertusssis toxin
transfer ADP ribose to Cys on alpha subunit of Gi
Gi cant bing AC and cant inh
inc Pka and camp exist in
cholera and pertussis
High insulin; low glucose (seizures)
High histamine; low pressure (shock)
Pertussis
TF hormone levels not affected in pertussis
F affected
termination of camp
pde converts it to 5’ amp
GC
converts GTP to cGMP
bind ssoluble GC on a heme
NO
binds to membrane ass GC
ANF
cGMP act
PKG
cGMP term to
5 gmp by cGMP Phosphodiesterase
Pi PE PC
polar head group of phosphpholipid
PIP2
Major Substrate for Producing Second Messengers
Phosphoinositide-4-Kinase
convert PI to PIP
PIP converted to PIP2 by
Phosphoinositide-5-Kinase
Activator of Ca2+ release from endoplasmic reticulum
IP3
phospholipase C
breaks PIP2 into DAG and IP3
DAG
Membrane bound
Activator of protein kinase C (PKC)
DAG
phsopholipase D
breaks PC into phosphatidic acid and choline
(1st step of DAG generation)

PAP
break phosphatidic acid ito DAG and PO4
(2nd step)

IP3 act
ip3sensitive channels to let out Ca
Ca bind protein kinase C which binds DAG (membrane) which phos substrates
Precursor for production of eicosanoids
Arachidonic acid (AA) –
