signal trans 4 part 2 Flashcards

1
Q
A
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2
Q

tf in cholera there is minimum loss of Na and water in intestines

A

F excessive

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3
Q

pertusssis toxin

A

transfer ADP ribose to Cys on alpha subunit of Gi

Gi cant bing AC and cant inh

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4
Q

inc Pka and camp exist in

A

cholera and pertussis

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5
Q

High insulin; low glucose (seizures)

High histamine; low pressure (shock)

A

Pertussis

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6
Q

TF hormone levels not affected in pertussis

A

F affected

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7
Q

termination of camp

A

pde converts it to 5’ amp

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8
Q

GC

A

converts GTP to cGMP

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9
Q

bind ssoluble GC on a heme

A

NO

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10
Q

binds to membrane ass GC

A

ANF

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11
Q

cGMP act

A

PKG

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12
Q

cGMP term to

A

5 gmp by cGMP Phosphodiesterase

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13
Q

Pi PE PC

A

polar head group of phosphpholipid

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14
Q

PIP2

A

Major Substrate for Producing Second Messengers

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15
Q

Phosphoinositide-4-Kinase

A

convert PI to PIP

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16
Q

PIP converted to PIP2 by

A

Phosphoinositide-5-Kinase

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17
Q

Activator of Ca2+ release from endoplasmic reticulum

A

IP3

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18
Q

phospholipase C

A

breaks PIP2 into DAG and IP3

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19
Q

DAG

A

Membrane bound

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20
Q

Activator of protein kinase C (PKC)

A

DAG

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21
Q

phsopholipase D

A

breaks PC into phosphatidic acid and choline

(1st step of DAG generation)

22
Q

PAP

A

break phosphatidic acid ito DAG and PO4

(2nd step)

25
Q

IP3 act

A

ip3sensitive channels to let out Ca

Ca bind protein kinase C which binds DAG (membrane) which phos substrates

26
Q

Precursor for production of eicosanoids

A

Arachidonic acid (AA) –

27
phosphlipase A2
breaks PIP2 into AA(membrane bound) and
28
PI
only has PO4 on 1 position
29
PIP
PO4 on 4 position
30
PIP2
po4 on 1,4,5 position
31
tf phosphatase can convert PIP3 to PIP2 to PIP1 to PI
T
32
PIP3
Activator of kinases recruited to membrane
33
PI 3 kinase
puts po4 on 3 position converts PIP2 to PIP3
35
exist in cytoplasm
camp cgmp ip3
36
membrane
DAG AA PIP3
37
tf IP3 and PIP3 use PIP2 as a source
T
38
AA and DAG
use PC and PE as a source
39
uses PI PIP PIP2 as sources
AA
40
tf dag can use PIP2 as source
T
41
ATP;GTP as source
camp; cgmp
42
43
Forms eicosanoids
AA
44
Activates PKB, PDK1
PIP3
45
act. pkg;pkc
cGMP;DAG
46
act pka
camp
47
release Ca from ER
IP3
48
effector AC ; GC
camp; cgmp
49
Pla2 is effector enzyme for
AA
50
pi 3k effector enzyme for
PIP3
51
PLC is effector nzyme for
IP3 and DAG
52
PLD/PAP effector enzyme fore
DAG
53
GC effector enzyme for
cGMP