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biochem block3 part 2 > signal trans 4 part 2 > Flashcards

signal trans 4 part 2 Flashcards

1
Q
A
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2
Q

tf in cholera there is minimum loss of Na and water in intestines

A

F excessive

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3
Q

pertusssis toxin

A

transfer ADP ribose to Cys on alpha subunit of Gi

Gi cant bing AC and cant inh

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4
Q

inc Pka and camp exist in

A

cholera and pertussis

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5
Q

High insulin; low glucose (seizures)

High histamine; low pressure (shock)

A

Pertussis

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6
Q

TF hormone levels not affected in pertussis

A

F affected

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7
Q

termination of camp

A

pde converts it to 5’ amp

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8
Q

GC

A

converts GTP to cGMP

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9
Q

bind ssoluble GC on a heme

A

NO

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10
Q

binds to membrane ass GC

A

ANF

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11
Q

cGMP act

A

PKG

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12
Q

cGMP term to

A

5 gmp by cGMP Phosphodiesterase

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13
Q

Pi PE PC

A

polar head group of phosphpholipid

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14
Q

PIP2

A

Major Substrate for Producing Second Messengers

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15
Q

Phosphoinositide-4-Kinase

A

convert PI to PIP

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16
Q

PIP converted to PIP2 by

A

Phosphoinositide-5-Kinase

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17
Q

Activator of Ca2+ release from endoplasmic reticulum

A

IP3

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18
Q

phospholipase C

A

breaks PIP2 into DAG and IP3

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19
Q

DAG

A

Membrane bound

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20
Q

Activator of protein kinase C (PKC)

A

DAG

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21
Q

phsopholipase D

A

breaks PC into phosphatidic acid and choline

(1st step of DAG generation)

22
Q

PAP

A

break phosphatidic acid ito DAG and PO4

(2nd step)

25
Q

IP3 act

A

ip3sensitive channels to let out Ca

Ca bind protein kinase C which binds DAG (membrane) which phos substrates

26
Q

Precursor for production of eicosanoids

A

Arachidonic acid (AA) –

27
Q

phosphlipase A2

A

breaks PIP2 into AA(membrane bound)

and

28
Q

PI

A

only has PO4 on 1 position

29
Q

PIP

A

PO4 on 4 position

30
Q

PIP2

A

po4 on 1,4,5 position

31
Q

tf phosphatase can convert PIP3 to PIP2 to PIP1 to PI

A

T

32
Q

PIP3

A

Activator of kinases recruited to membrane

33
Q

PI 3 kinase

A

puts po4 on 3 position

converts PIP2 to PIP3

35
Q

exist in cytoplasm

A

camp

cgmp

ip3

36
Q

membrane

A

DAG

AA

PIP3

37
Q

tf IP3 and PIP3 use PIP2 as a source

A

T

38
Q

AA and DAG

A

use PC and PE as a source

39
Q

uses PI PIP PIP2 as sources

A

AA

40
Q

tf dag can use PIP2 as source

A

T

41
Q

ATP;GTP as source

A

camp; cgmp

42
Q
A
43
Q

Forms eicosanoids

A

AA

44
Q

Activates PKB, PDK1

A

PIP3

45
Q

act. pkg;pkc

A

cGMP;DAG

46
Q

act pka

A

camp

47
Q

release Ca from ER

A

IP3

48
Q

effector AC ; GC

A

camp; cgmp

49
Q

Pla2 is effector enzyme for

A

AA

50
Q

pi 3k effector enzyme for

A

PIP3

51
Q

PLC is effector nzyme for

A

IP3 and DAG

52
Q

PLD/PAP effector enzyme fore

A

DAG

53
Q

GC effector enzyme for

A

cGMP

biochem block3 part 2 (13 decks)

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