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biochem block3 part 2 > CT 2 part 2 > Flashcards

CT 2 part 2 Flashcards

1
Q
A
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2
Q

binds ECM and transmembrane proteins

A

fibronectins and laminins

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3
Q

linker protein-mediated “communication”.

A

fibronectins and laminins

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4
Q

alpha beta subunit

A

integrin

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5
Q

tf

Cells can have 1 integrin receptors that link the cell to only one component of the extracellular matrix.

A

Cells can have multiple integrin receptors that link the cell to more than one component of the extracellular matrix.

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6
Q

The ——/—– sequence on the linker proteins binds specifically to the integrin receptors.

A

RGD/RGDS sequence on the linker proteins

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7
Q

Activation of integrins can lead to their — and —— of focal adhesions

A

Activation of integrins can lead to their clustering and formation of focal adhesions

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8
Q

C terminus of alpha and beta subunits of integrin

A

located in cytoplams

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9
Q

alpha subunit split into 2 segments

A

and linked together by disulfide linkage

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10
Q

disulfide rich repeats exist in

A

beta subunit of integrin

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11
Q

integrin binds to actin on

A

cytoskeleton side

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12
Q

out to in signal of integrin

A

ligand binds from ECM

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13
Q

Out to in signal in integrin

A

cell polarity

surviva;

proliferation

cytoskeletal structure

gene expression

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14
Q

Talin

A

involved in in to out signaling with integrin

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15
Q

cell migration

cell adhesion

ECM assembly

A

In to Out signaling with integrin

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16
Q

regulation of the extracellular binding activity of a cell’s integrins from within.

A
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18
Q

collagen

A

GP

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19
Q

Chemotaxis

A

Collagen

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20
Q

(major stress-bearing component

A

Colagen

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21
Q

Collagens form —– fibers with high —- strength; hold cells together in discrete units.

A

Collagens form insoluble fibers with high tensile strength; hold cells together in discrete units.

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22
Q

By weight, —- of the protein in vertebrates is collagen

A

By weight, 1/4 of the protein in vertebrates is collagen

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23
Q

cornea cartiledge

A

high percent collagen by weight

64 50

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24
Q

highest percent collagen by weight

A

skin 74

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25
Q

liver lung

A

small percent colagen by wieght

4 and 10

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26
Q

cOrtical Bone

aOrta

A

23%

10-24%

% collagen by wieght

27
Q

after fibroblast make polypeptide system

A

OH and glycosylation occurs(collagen)

28
Q

Secretion of procolllagen is followed by

A

hydrolysis of peptide bond to form tropocollagen

29
Q

self assembly of tropocolagen to form

A

collagen fibers

30
Q

crosslink in colagen fiber leads to

A

mature collagen fiber

31
Q

tf collagen fber is made in between

procolagen and tropocollagen

A

F after tropocollagen

32
Q

tf collagenis product of few genes

and few types

A

F over 40 genes

28 types

33
Q

types 2 and 3 collagen

A

homotrimers

34
Q

collagen 1,4,5

A

heterotrimers

35
Q

polppetide in collegen

A

alpha

36
Q

placenta skin

A

type 5 collagen

37
Q

basment membrane

A

type 4 collagen

38
Q

cartildge IVD

A

collagen 2

39
Q

skin tendon

A

type 1 collagen

40
Q

bone dentin

A

type 1 collagen

41
Q

BV uterus reticular fibers

A

type 3 collagen

42
Q

triple helical rod

A

collagen

43
Q

Remarkably strong

Forms an insoluble fiber with high tensile strength

A

collagen

44
Q

collagen

A

3000 Å long and 15 Å diameter

45
Q

1/3 of the amino acids in collagen

A

Glycine

46
Q

Proline

4-Hydroxyproline (Hyp)

3-Hydroxyproline (Hyp)

A

collagen

47
Q

5-Hydroxylysine

A

collagen

48
Q

tf collgen has Charged (—) amino acids

A

F

Charged (positive) amino acids

49
Q

highest component in collagen and elastin

A

Gly

50
Q

5 hydroxylysine

A

not present in elastin

present in collagn

51
Q

desmosine and isodesmosine not in

A

collagen

52
Q

collagen primary structure

A

glu X Y

53
Q

X

A

Proline

54
Q

Y

A

hydroxyproline

55
Q

polar basic AA

A

also in collagen

56
Q

X

A

proline

57
Q

tf 3 hydroxylysine is in collagen

A

F

5 hydroxylysine

58
Q

Y

A

hydroxyproline

59
Q
A
60
Q

secondary structure of collagen

A

tropocollagen with left handed helical structure

61
Q

type 2 trans helix

A

2nd and tert structure of Collagen

62
Q

quat structure

A

type 2 transhelix twist around each other to form right handed helix(superhelix)

63
Q

triple helix of tropocollagen

A

has glycine in the middle

biochem block3 part 2 (13 decks)

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