signal trans 3 part 1

Question 2

Hydrophobic hormones

Answer 2

ligand for intracellular receptor

Question 3

NT

Answer 3

ligand for Ligand-Gated Ion Channel and G pro coupled receptor

Question 4

GF

Answer 4

ligand for EnzymeLinked and cytokine receptor

Question 5

hormones and GF

Answer 5

ligand for EnzymeLinked receptor

Question 6

Cytokines Growth factors

Answer 6

ligand for cytokine receptor

Question 7

Hormones Cytokines

Answer 7

ligand for G-ProteinCoupled

Question 8

only receptor on cytoplasm/ nucleus

Answer 8

intracell receptor (all others are on cel surface)

Question 9

Dimeric/tetrameric complex of transmembrane polypeptides with intracellular catalytic domain

Answer 9

Enzyme linked receptor

Question 10

 Activates autophosphorylation

Answer 10

EnzymeLinked receptor

Question 11

 Single polypeptide with 7 trans- membrane domains 

Answer 11

G-ProteinCoupled

Question 12

Activates trimeric G protein

Answer 12

G-ProteinCoupled

Question 13

Multimeric ring-like complex of 3-5 polypeptides with multiple transmembrane domains

Answer 13

Ligand-Gated Ion Channel

Question 14

tf Ligand-GatedIon Channel lack transmembrane domain

Answer 14

F has it

Question 15

Opens internal water-filled pore

Answer 15

Ligand-GatedIon Channel

Question 16

Polypeptide dimer with DNA- binding domains

Answer 16

intracell receptor

Question 17

Binds as dimer to DNA sequence

Answer 17

intracell receptor

Question 18

Activates cytoplasmic enzymes

Answer 18

cytokine receptor

Question 19

Multimeric complex of trans- membrane polypeptides lacking intrinsic catalytic activity

Answer 19

cytokine receptor

Question 20

Tf cytokine receptor has intrinsic cat. activity

Answer 20

F lacks it

Question 21

SH2 domain

Answer 21

2 α-helices flanking β-sheet (antiparallel)

Question 22

β-barrel (antiparallel) followed by C-term α-helix  Binds in cleft between helix and strands

Answer 22

PTB domian

Question 23

Binds in deep pocket lined with + residues

Answer 23

SH2

Question 24

Binds in cleft between helix and strands

Answer 24

PTB domain

Question 25

SH3 domain

Answer 25

Binds in shallow hydrophobic pocket

Question 28

PH domain

Answer 28

Binds in cleft between loops connecting strands

Question 30

β-barrel fold (2 antiparallel β-sheets)

Answer 30

SH3 domain

Question 31

2 perpendicular β-sheets (antiparallel) followed by C-term amphipathic α-helix

Answer 31

PH domain

Question 33

binding affinity phos. tyrosines

Answer 33

sh2 and ptb

Question 34

bidning affinity of prolines

Answer 34

SH3 domain

Question 35

phos. inositol PL binding affinity

Answer 35

PH domain

Question 36

Receptors have an appropriate—- —– (dissociation constant, KD ) for the signaling molecule in order to detect it at the likely ——- in the vicinity of the cell.

Answer 36

Receptors have an appropriate binding affinity (dissociation constant, KD ) for the signaling molecule in order to detect it at the likely concentration in the vicinity of the cell.

criteria 1 of receptors

Question 37

Receptors transmit the —- of the signaling molecule by modulation of further—– in the signaling cascade.

Answer 37

Receptors transmit the message of the signaling molecule by modulation of further components in the signaling cascade.

Criteria 2 of receptor

Question 38

Receptors display ——- by detecting only those signaling molecules which the cell wants to perceive.

criteria 3 of reeptors

Answer 38

Receptors display specificity by detecting only those signaling molecules which the cell wants to perceive

criteria 3 of receptor

Question 39

Nicotinic Acetylcholine Receptor

Answer 39

cationic selective

Question 40

ligand gate ion channel term.

Answer 40

Question 41

subunits of nicotinic ach receptor

Answer 41

Subunit with 4 transmembrane domains – M1, M2 (amphipathic), M3, and M4 – and 2 intracellular loops

Question 42

tf both the N and C terminal in the nicotinic ach receptor is in the extracell space

Answer 42

T

Question 43

termination of ligand gated ion channel

Answer 43

Diffusion away from the receptor and synaptic gap Degradation by enzymes on the cell surface (e.g., acetylcholinesterase)

 Re-uptake into the pre-synaptic neuron

Question 44

Formation of an —— ligand—— state (non—– form of receptor inactivation) ensures very —- periods of signal transduction.

Answer 44

Formation of an inactive ligand-bound state (noncovalent form of receptor inactivation) ensures very brief periods of signal transduction.

Question 46

Small ligands bind in pocket.

Large ligands bind to extracellular loops.

Answer 46

GPCR

Question 47

Polypeptide dimer with DNA- binding domains  Binds as dimer to DNA sequence

Answer 47

Intracellular receptor

Question 48

Binds as dimer to DNA sequence

Answer 48

intracell receptor