CT 1 part 1

Question 2

TF CT has only structural role

Answer 2

F its dynamic and Biologically interactive function

Question 3

Connective tissue was critical to the evolution of ——– organisms.

Answer 3

Connective tissue was critical to the evolution of multicellular organisms.

Question 4

❂ Extracellular matrix (ECM) is the material outside of the cells and —– and ——borders.

Answer 4

❂ Extracellular matrix (ECM) is the material outside of the cells and epithelial and endothelial borders.

Question 5

CT

Answer 5

cells plus the ECM

Question 6

TF The ECM is an extension of the cell and participates PassivELY in cell function.

Answer 6

The ECM is an extension of the cell and participates ACTIVELY in cell function.

Question 7

CT

Answer 7

Stabilize the physical structure of tissues

Question 8

protein PG GP

Answer 8

CT

Question 9

major protein of CT

Answer 9

elastin

Question 10

Allowed emergence of efficient circulatory and respiratory systems

Answer 10

elastin

Question 11

order the following Translation Transcription (tropoelastin and microfibril components) Fiber formation Secretion

Answer 11

Transcription (tropoelastin and microfibril components) Translation Secretion Fiber formation

Question 12

igf1 , tgf beta

Answer 12

ELN increased

Question 13

TNFα (bFGF) HB-EGF

Answer 13

Decrease ELN transcription

Question 14

The product of the ELN gene is

Answer 14

The product of the ELN gene is tropoelastin

Question 15

Tropoelastin

Answer 15

Tropoelastin is secreted into the ECM.

Question 16

Cross-linking renders the elastin fiber highly insoluble.—–

Answer 16

Cross-linking renders the elastin fiber highly insoluble.

Question 17

crosslinking of Tropoelastin

Answer 17

elastin fiber

Question 18

ECM;

Answer 18

tropelastin + microfibrils

Question 19

tf tropoelastin nevr binds to microfibrils

Answer 19

F they bind

Question 20

lysyl oxidase

Answer 20

mediates cross linking

Question 21

tf elastin molecules can expand and contract

Answer 21

T

Question 22

TF Treatment with NaOH at high temperature solubilizes virtually all proteins and the insoluble elastin.

Answer 22

Treatment with NaOH at high temperature solubilizes virtually all proteins, but not the insoluble elastin.

Question 23

Tf In vitro, there are enzymes known as elastases that can cleave the elastin fiber.

Answer 23

In vivo, there are enzymes known as elastases that can cleave the elastin fiber.

Question 24

cutis laxa

Answer 24

elastin mut–> skin laxity

Question 25

narrow aorta , heart failure

Answer 25

Supravalvular aortic stenosis

Question 26

rupture of aorta

Answer 26

Aortic aneurysm (ellastin problem)

Question 27

lesions from plaque rupture leads to heart attack and stroke

Answer 27

Atherosclerosis (ellastin problem)

Question 28

heart defect dental defect varying degrees of cognition issues

Answer 28

Williams syndrome

Question 29

william syndrome

Answer 29

hypersociable and face morphology

Question 30

chromosome 7 deletion and elastin deletion

Answer 30

william syndrome

Question 31

after simulation of orthodontic force; Expression of tropoelastin in human periodontal ligament fibroblasts

Answer 31

increased significantly

Question 32

Niccolò Paganini Bradford Cox

Answer 32

Marfan’s Syndrome (Fibrillin Mutations)

Question 33

hypermobility and heart issus

Answer 33

Niccolò Paganini Bradford Cox

Question 34

Cardiovascular ❂ Ocular

Answer 34

Marfans’ syndrome

Question 35

Skeletal ❂ Bone overgrowth ❂ Joint laxity

Answer 35

Marfan’s syndrome

Question 36

Periodontal disease

Answer 36

Marfan’s syndrome

Question 37

mutation fibrillin in Marfan’s disease

Answer 37

cant hold tgf beta

Question 38

matrix metaloprotein release

Answer 38

lead to tissue degradation –> CV problem and periodontitis

Question 40

Form a highly hydrated, gel-like ground substance

Answer 40

PG

Question 41

tf PG are homogenious

Answer 41

F

have other substances embedded in it like bfgf

Question 42

PG

Answer 42

carb rich

Question 43

polyanion and bind water

Answer 43

PG