Lipid 2 part 2 Flashcards
carry TG
CM and VLDL
CE carried by
LDL
CE and phospholipids
carried by hdl
how to get rid of cholesterol
—>liver–> bile salts—> SI—> secreted in feces
– plasma enzyme (in the bloodstream)
LPL
breaks down TG→FA
LPL
activated as cofactor APO-C (CM and VLDL)
LPL
Lecithin cholesterol acyl transferase (LCAT
acyl chains on lecithin and transfers to cholesterol to make a CE
– activated by cofactor APO-A (HDL)
Lecithin cholesterol acyl transferase (LCAT
activated by cofactor APO-A (HDL) in the bloodstream
LCAT
takes acyl Co-A and cholesterol inside of liver cells
ACAT
in liver cell
ACAT
HMG Co-A Reductase
makes cholesterol the rate limiting step of cholesterol biosynthesis
Intracellular enzymes
HMG Co-A Reductase ACAT
in blood stream
LDL
LPL cofactor
apo C
APO-B –
ligand for LDL receptor
APO-A –
LCAT cofactor
APO-A –
ligand for 2 receptors/transporters ABCA1&SRB1
lipoprotein
phospholipid with apoprotein croplet containing TG and CE
apo protein
stabilize droplet and have act enzyme and transporters
chylomicron
made from interstinal mucosal cell
ACAT
Chol-> CE in int. mucosal cell