CT 1 part 2

Question 3

has low amt of protein in it (5%)

Answer 3

PG

Question 4

Osteoporosis and Osteoarthritis

Answer 4

PG ass disease

Question 5

hyper extensible skin and joints

fragile BV

Answer 5

ehlers danlos

Question 6

Ostero arthritis

Answer 6

lower bone mass(loss of PG components)

Question 7

deg joint disease

Answer 7

Osteoarthritis

Question 8

corneal disease

Answer 8

disfunction of PG

Question 9

tooth development •

dentin formation and mineralization •

adhesion and fusion of the palatal shelves

Answer 9

PG in oral cavity

Question 10

Proteoglycan-associated sugars

Answer 10

chondroitin sulfate and heparan sulfate

Question 11

(chondroitin sulfate and heparan sulfate

Answer 11

expressd in PDL in responce to orthodontic force

Question 12

periodontal regeneration.

Answer 12

Decorin (up-regulated)

Biglycan (down-regulated

types of PG

Question 13

Delivery of perlecan (heparan sulfate) may serve as a potential adjunct to stimulate — ——-

Answer 13

Delivery of perlecan (heparan sulfate) may serve as a potential adjunct to stimulate bone-regeneration.

Question 14

Delivery of perlecan (heparan sulfate) may trigger

Answer 14

tumorigenesis

Question 15

promoting cell adhesion,

and angiogenesis

Answer 15

Perlican

Question 16

proliferation, differentiation

Answer 16

perlican(PG)

Question 17

angiogenesis

Answer 17

PG

Question 18

Proteins + glycosaminoglycan

Answer 18

Proteins + glycosaminoglycans = proteoglycans

Question 19

tf Proteins + glycosaminoglycans are non covalently linked

Answer 19

F covalently linked

Question 20

glucosamine or galactosamine

Answer 20

conatined in GAG(at least 1)

Question 21

At least one of the sugars in the disaccharide of GAG is ——-

charged

Answer 21

At least one of the sugars in the disaccharide is negatively charged

Question 22

Negatively charged groups are either —– or —— groups

Answer 22

Negatively charged groups are either carboxylate or sulfate groups

Question 23

Disaccharide repeating units

Answer 23

GAGs

Question 24

Answer 24

Question 25

where on sugar is amine groups and acetyl groups added

Answer 25

Question 26

Hyaluronic acid is a —— of alternating units of glucuronic acid and N-acetylglucosamine.

Answer 26

Hyaluronic acid is a heteropolymer of alternating units of glucuronic acid and N-acetylglucosamine.

Question 28

carboxylated in Hyaluronan GAG

Answer 28

glucoronic acid

Question 29

iduronic acid and N-acetylgalactosamine 4 sulfate

Answer 29

Question 32

Only GAG found free i.e. not covalently linked to a protein core.

Answer 32

Hyaluronic acid

Question 35

carboxylate and sulffates

Answer 35

iduronic acid and N-acetylgalactosamine

dermatan sulfate GAG

Question 36

heparin sulfate

Answer 36

3 types of domains

sulfated domain

sulfated/acetylated domain

acetylated domain

Question 37

long or short

hydration varies

Answer 37

GAG

Question 38

Gag bind to core protein in PG through

Answer 38

tetrasaccharide

Question 39

middle of agrecan

Answer 39

Question 40

o linked sugard

Answer 40

core protein to tetrasccharide

Question 41

PG

Answer 41

1 core many gags

Question 42

tetrasach. linkage allows

Answer 42

SEr to be covalently linked to xylose(of link tetra sacc)

Question 43

TF PG doesnt show variation with size

Answer 43

F 11KDa ro 220 KDa

Question 44

acan

Answer 44

encodes aggrecan

Question 46

linker protein of aggrecan

Answer 46

links core protein to hyaluronic acid

Question 47

linker protein

Answer 47

non cov linkage

Question 48

GAGs to core protein

Answer 48

Covalent linkage