CT 2 part 1

Question 2

❂ Laminins

Answer 2

(basal laminae) (GP)

Question 3

fibronectin

Answer 3

widely distributed GP

Question 4

Collagens

Answer 4

most widely distributed protein in the body(GP)

Question 5

Tf Glycoproteins have covalently-bound carbohydrate.

Answer 5

t Glycoproteins have covalently-bound carbohydrate.

Question 6

the hydroxyl group ( -OH ) of serine or threonine • the hydroxyl group ( -OH ) of hydroxylysine

Answer 6

called “O-linked” in GP

Question 7

(only in collagens)

Answer 7

hydroxylysine in GP

Question 8

the amide group [-NH2] of asparagine -

Answer 8

called “N-linked”.

Question 9

tf sugar residue Render glycoproteins more hydrophilic

Answer 9

t

Question 10

sugar residues stabilize against —– and ——- binding to some components

Answer 10

Sugar stabilize against hydrolysis and modulate binding to some components

Question 11

Linker Proteins

Answer 11

Fibronectins

Question 12

Interlink collagens, proteoglycans with cell surface receptors

Answer 12

Fibronectins

Question 13

Fibronectin

Answer 13

Enable cells to interact with the extracellular matrix

Question 14

Adhesion ❂ Differentiation

Answer 14

Fibronectin purpose

Question 15

Fibronectin purpose

Answer 15

Embryonic cell migration

Question 16

Fibronectin Determine —-, ——- organization

Answer 16

Determine cell shape, cytoskeletal organization

Question 17

Wound healing

Answer 17

Fibronectin

Question 18

cancer cells lose the ability to synthesize ———

Answer 18

cancer cells lose the ability to synthesize fibronectin

Question 19

In OC, fibronectin regulates

Answer 19

Dental mesenchyme differentiating into odontoblasts

Question 20

Carbohydrate accounts for —– of the weight of fibronectin

Answer 20

5%

Question 21

2 peptides connected in V like shape

Answer 21

Fibronectin

Question 22

fibronectin —> 2 x 250 kDa chains linked by disulfide bond near the C-terminus.

Answer 22

2 x —– kDa chains linked by disulfide bond near the — -terminus.

Question 23

Fibronectin

Answer 23

specialized domains for binding cell surface receptors and the extracellular matrix

Question 24

links the outer components of the cell to the cell itself.

Answer 24

Fibronectin

Question 25

RGD or RGDS

Answer 25

cell surface receptor-binding domain

Question 26

disulfide bonds connect fibronectin at

Answer 26

C terminal

Question 28

binding domain next to cell surface receptor bidning domain and near N terminal

Answer 28

fibrin binding domain

Question 29

fibrin heparin binding domain

Answer 29

most near c terminal of fibronectin (N to C)

Question 30

on the fibronectin structure which binding domain is most near N terminal

Answer 30

Heparin and Fibrin binding domain

Question 33

cell surface receptor binding domain

Answer 33

contains RGD or RGDS

Question 34

Laminin

Answer 34

linker proteins

Question 35

Enable epithelial cells to interact with the extracellular matrix

Answer 35

Laminin

Question 36

Laminin

Answer 36

high affinity for Type IV collagen

Question 37

diff ,adhesion

Answer 37

Laminin

Question 38

Embryonic nerve axonal outgrowth Nerve regeneration after injury

Answer 38

laminin

Question 39

Laminin in OC

Answer 39

contributing to terminal differentiation of ameloblasts and in enamel matrix formation.

Question 40

may also contribute to the growth of ameloblastomas

Answer 40

Laminin

Question 41

Expression of α2 and β2 of laminin

Answer 41

in fetal oral squamous epithelium

Question 42

α2 and β2 of laminin

Answer 42

Re-expression of these in adult oral squamous cell carcinomas

Question 43

low Carbohydrate(13%)

Answer 43

Laminin

Question 44

Laminin

Answer 44

Specialized domains bind cell surface receptors and the extracellular matrix i.e. links outer components of the cell to the cell surface.

Question 45

disulfide-linked heterotrimer

Answer 45

Laminin

Question 46

α, β and γ chains

Answer 46

Laminin

Question 47

cruciform shape

Answer 47

Laminin

Question 48

Laminin molecules ------associate to form ------.

Answer 48

Laminin molecules self-associate to form aggregates.

Question 49

For laminin

Answer 49

Nomenclature indicates chain composition

Question 50

Laminin network formation involve

Answer 50

Ca

Question 51

type 4 collagen and perlecan (extracelllar molecules)

Answer 51

bind laminin

Question 52

integrin

Answer 52

bind laminin and fibronectin binding site for the linker proteins

Question 53

transmembrane proteins and GP

Answer 53

integrin

Question 54

The cytoplasmic side of integrins binds to ----- components. The extracellular domain of integrins binds to ----- and -----

Answer 54

The cytoplasmic side of integrins binds to cytoskeletal components. ❂ The extracellular domain of integrins binds to fibronectins and laminins