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biochem block3 part 2 > CT 2 part 1 > Flashcards

CT 2 part 1 Flashcards

1
Q
A
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2
Q

❂ Laminins

A

(basal laminae) (GP)

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3
Q

fibronectin

A

widely distributed GP

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4
Q

Collagens

A

most widely distributed protein in the body(GP)

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5
Q

Tf Glycoproteins have covalently-bound carbohydrate.

A

t Glycoproteins have covalently-bound carbohydrate.

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6
Q

the hydroxyl group ( -OH ) of serine or threonine • the hydroxyl group ( -OH ) of hydroxylysine

A

called “O-linked” in GP

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7
Q

(only in collagens)

A

hydroxylysine in GP

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8
Q

the amide group [-NH2] of asparagine -

A

called “N-linked”.

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9
Q

tf sugar residue Render glycoproteins more hydrophilic

A

t

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10
Q

sugar residues stabilize against —– and ——- binding to some components

A

Sugar stabilize against hydrolysis and modulate binding to some components

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11
Q

Linker Proteins

A

Fibronectins

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12
Q

Interlink collagens, proteoglycans with cell surface receptors

A

Fibronectins

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13
Q

Fibronectin

A

Enable cells to interact with the extracellular matrix

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14
Q

Adhesion ❂ Differentiation

A

Fibronectin purpose

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15
Q

Fibronectin purpose

A

Embryonic cell migration

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16
Q

Fibronectin Determine —-, ——- organization

A

Determine cell shape, cytoskeletal organization

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17
Q

Wound healing

A

Fibronectin

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18
Q

cancer cells lose the ability to synthesize ———

A

cancer cells lose the ability to synthesize fibronectin

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19
Q

In OC, fibronectin regulates

A

Dental mesenchyme differentiating into odontoblasts

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20
Q

Carbohydrate accounts for —– of the weight of fibronectin

A

5%

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21
Q

2 peptides connected in V like shape

A

Fibronectin

22
Q

fibronectin —> 2 x 250 kDa chains linked by disulfide bond near the C-terminus.

A

2 x —– kDa chains linked by disulfide bond near the — -terminus.

23
Q

Fibronectin

A

specialized domains for binding cell surface receptors and the extracellular matrix

24
Q

links the outer components of the cell to the cell itself.

A

Fibronectin

25
Q

RGD or RGDS

A

cell surface receptor-binding domain

26
Q

disulfide bonds connect fibronectin at

A

C terminal

28
Q

binding domain next to cell surface receptor bidning domain and near N terminal

A

fibrin binding domain

29
Q

fibrin heparin binding domain

A

most near c terminal of fibronectin (N to C)

30
Q

on the fibronectin structure which binding domain is most near N terminal

A

Heparin and Fibrin binding domain

33
Q

cell surface receptor binding domain

A

contains RGD or RGDS

34
Q

Laminin

A

linker proteins

35
Q

Enable epithelial cells to interact with the extracellular matrix

A

Laminin

36
Q

Laminin

A

high affinity for Type IV collagen

37
Q

diff ,adhesion

A

Laminin

38
Q

Embryonic nerve axonal outgrowth

Nerve regeneration after injury

A

laminin

39
Q

Laminin in OC

A

contributing to terminal differentiation of ameloblasts and

in enamel matrix formation.

40
Q

may also contribute to the growth of ameloblastomas

A

Laminin

41
Q

Expression of α2 and β2 of laminin

A

in fetal oral squamous epithelium

42
Q

α2 and β2 of laminin

A

Re-expression of these in adult oral squamous cell carcinomas

43
Q

low Carbohydrate(13%)

A

Laminin

44
Q

Laminin

A

Specialized domains bind cell surface receptors and the extracellular matrix i.e.

links outer components of the cell to the cell surface.

45
Q

disulfide-linked heterotrimer

A

Laminin

46
Q

α, β and γ chains

A

Laminin

47
Q

cruciform shape

A

Laminin

48
Q

Laminin molecules ——associate to form ——.

A

Laminin molecules self-associate to form aggregates.

49
Q

For laminin

A

Nomenclature indicates chain composition

50
Q

Laminin network formation involve

A

Ca

51
Q

type 4 collagen and perlecan (extracelllar molecules)

A

bind laminin

52
Q

integrin

A

bind laminin and fibronectin

binding site for the linker proteins

53
Q

transmembrane proteins

and GP

A

integrin

54
Q

The cytoplasmic side of integrins binds to —– components.

The extracellular domain of integrins binds to —– and —–

A

The cytoplasmic side of integrins binds to cytoskeletal components. ❂ The extracellular domain of integrins binds to fibronectins and laminins

biochem block3 part 2 (13 decks)

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