Side Effects of Reproductive drugs Flashcards
what drug increases the risk of uterine sarcoma, endometrial cancer and thromboembolic events?
Tamoxifen (soltamox)
what drug causes decreased risk of endometrial and uterine sarcoma
Raloxifene (Evista)
what drug can cause visual disturbances?
Clomiphene
what class of drugs causes hotflashes?
SERM selective estorgen receptor modulators
what drug can cause vaginal clear cell carcinoma for pts ecpsoed to DES
Ethinyl Estradiol and Mestranol (synthetic estrogens)
what drug class is associated with increased risk of endometrial cancer, CNS symptoms, thromboembolic events and cardio events
synthetic estrogens
what drug class is associated with an increased risk of osteoporosis
aromatase inhibitors (anastrozole, letrozole, exemstane)
what are some side effects of aromatose inhibitors?
- hot flashes
- vaginal dryness
- myalgia
- dyspnea
- nausea
- fatigue
- htn
what drug is associated with weight gain, hirsutism, acne?
Danazol
what drug is associated with decreased HDL levels?
Danazol
what drug is associated with idopathic intracranial HTN
Danazol
what drugs are associated with gynecomastia
- finasteride
- flutamide/bicalutamide
- spironolactone
- ketoconazole
what antiandrogen is associated with sexual dysfunction?
finasteride
what drugs are associated with hypogonadism
Flutamide and Bicalutamide
what antiandrogen is associated with breast tenderness and amenorrhea
spironolactone
does estorgen or progestins have a higher chance of breakthrough bleeding?
progestins
what is associated with progestin therapy
- weight gain
- thromboembolism
- bloating
- dizziness
what se are associated with Mifepristone
- abdominal pain
- headache
- weakness
- nausea
what drug is associated with endometrial thickening
Ulipristal (Ella)
for what side effects should you immediately discontinue progestin?
- impaired vision
- masses
- migraine headaches with aura
- epilepsy
- jaundice
- pregnancy
what are side effects of IUD
- abnormal uterine bleeding
- dysmenorrhea
- pelvic pain
- uterine perforation
what are side effects of oral contraceptives (combined)
- decreased libido
- fatigue
- nausea/dizziness
what contraception can cause bone mineral loss
Depo-provera
what drug can cause drug induced liver injury
Ulipristal acestate (Ella)
why are OCP not recommended while breast feeding?
They can lower the production of milk (because of the estrogen)
