Side Effects of Reproductive drugs

Question 1

what drug increases the risk of uterine sarcoma, endometrial cancer and thromboembolic events?

Answer 1

Tamoxifen (soltamox)

Question 2

what drug causes decreased risk of endometrial and uterine sarcoma

Answer 2

Raloxifene (Evista)

Question 3

what drug can cause visual disturbances?

Answer 3

Clomiphene

Question 4

what class of drugs causes hotflashes?

Answer 4

SERM selective estorgen receptor modulators

Question 5

what drug can cause vaginal clear cell carcinoma for pts ecpsoed to DES

Answer 5

Ethinyl Estradiol and Mestranol (synthetic estrogens)

Question 6

what drug class is associated with increased risk of endometrial cancer, CNS symptoms, thromboembolic events and cardio events

Answer 6

synthetic estrogens

Question 7

what drug class is associated with an increased risk of osteoporosis

Answer 7

aromatase inhibitors (anastrozole, letrozole, exemstane)

Question 8

what are some side effects of aromatose inhibitors?

Answer 8

• hot flashes
• vaginal dryness
• myalgia
• dyspnea
• nausea
• fatigue
• htn

Question 9

what drug is associated with weight gain, hirsutism, acne?

Answer 9

Danazol

Question 10

what drug is associated with decreased HDL levels?

Answer 10

Danazol

Question 11

what drug is associated with idopathic intracranial HTN

Answer 11

Danazol

Question 12

what drugs are associated with gynecomastia

Answer 12

• finasteride
• flutamide/bicalutamide
• spironolactone
• ketoconazole

Question 13

what antiandrogen is associated with sexual dysfunction?

Answer 13

finasteride

Question 14

what drugs are associated with hypogonadism

Answer 14

Flutamide and Bicalutamide

Question 15

what antiandrogen is associated with breast tenderness and amenorrhea

Answer 15

spironolactone

Question 16

does estorgen or progestins have a higher chance of breakthrough bleeding?

Answer 16

progestins

Question 17

what is associated with progestin therapy

Answer 17

• weight gain
• thromboembolism
• bloating
• dizziness

Question 18

what se are associated with Mifepristone

Answer 18

• abdominal pain
• headache
• weakness
• nausea

Question 19

what drug is associated with endometrial thickening

Answer 19

Ulipristal (Ella)

Question 20

for what side effects should you immediately discontinue progestin?

Answer 20

• impaired vision
• masses
• migraine headaches with aura
• epilepsy
• jaundice
• pregnancy

Question 21

what are side effects of IUD

Answer 21

• abnormal uterine bleeding
• dysmenorrhea
• pelvic pain
• uterine perforation

Question 22

what are side effects of oral contraceptives (combined)

Answer 22

• decreased libido
• fatigue
• nausea/dizziness

Question 23

what contraception can cause bone mineral loss

Answer 23

Depo-provera

Question 24

what drug can cause drug induced liver injury

Answer 24

Ulipristal acestate (Ella)

Question 25

why are OCP not recommended while breast feeding?

Answer 25

They can lower the production of milk (because of the estrogen)