Vasodilator for Angina Pectoris Notes Flashcards

1
Q

what is the primary cause of angina pectoris

A

imbalance between O2 requirement of the heart and the O2 supplied via coronary vessels

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2
Q

What is effort angina

A

imbalance due to increase o2 requirement (exercise)

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3
Q

what is the result of an imbalance of O2 req. and O2 supplied?

A

ischemia with accumulation of acidic metabolites

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4
Q

what is unstable angina?

A

pain at rest

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5
Q

what causes unstable angina?

A

increased plaque (increased resistance)

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6
Q

what is ASA

A

something something- acid

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7
Q

what is variant angina?

A

spasm of the coronary vessels

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8
Q

How can variant angina be corrected?

A

Nitrate or calcium channel blocking vasodilatorrs

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9
Q

What is the therapy goal of treating unstable angina?

A

increase O2 delivery and decrease O2 demand

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10
Q

What causes myocardial O2 requirement to increase?

A

increase in HR, contractility, arterial pressure, ventricular volume

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11
Q

What are the 4 types of drugs that relax vascular smooth muscle?

A
  1. increase cGMP
  2. Decrease intracellular Ca2+
  3. preventing the depolarization of the vascular sm membrane
  4. INcrease cAMP in vascular smooth muscle
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12
Q

how does cGMP impact Ca2+ and K+ channels?

A

increases permeability

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13
Q

what artery is more affected by Nitrates?

A

Veins

Most therapeutic effects of nitrates stem from venous pooling and decrea

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14
Q

what vessels are dilated least?

A

arterioles and precapillary sphincters

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15
Q

Why can syncope and hypotension occur?

A

bc venous capacitance is increased

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16
Q

what is Monday Disease?

A

industrial workers who are exposed to nitrates during the week, and then are rexposed on Monday experience
headaches
dizziness
tachycardia