Vasodilator for Angina Pectoris Notes Flashcards
what is the primary cause of angina pectoris
imbalance between O2 requirement of the heart and the O2 supplied via coronary vessels
What is effort angina
imbalance due to increase o2 requirement (exercise)
what is the result of an imbalance of O2 req. and O2 supplied?
ischemia with accumulation of acidic metabolites
what is unstable angina?
pain at rest
what causes unstable angina?
increased plaque (increased resistance)
what is ASA
something something- acid
what is variant angina?
spasm of the coronary vessels
How can variant angina be corrected?
Nitrate or calcium channel blocking vasodilatorrs
What is the therapy goal of treating unstable angina?
increase O2 delivery and decrease O2 demand
What causes myocardial O2 requirement to increase?
increase in HR, contractility, arterial pressure, ventricular volume
What are the 4 types of drugs that relax vascular smooth muscle?
- increase cGMP
- Decrease intracellular Ca2+
- preventing the depolarization of the vascular sm membrane
- INcrease cAMP in vascular smooth muscle
how does cGMP impact Ca2+ and K+ channels?
increases permeability
what artery is more affected by Nitrates?
Veins
Most therapeutic effects of nitrates stem from venous pooling and decrea
what vessels are dilated least?
arterioles and precapillary sphincters
Why can syncope and hypotension occur?
bc venous capacitance is increased
