Indications & CI for Reproductive Flashcards
Tamoxifen is indicated for
- breast cancer tx
- premenopausal estrogen receptor positive breast cancer
- vaginal atrophy
Raloxifene (evista) is indicated for
- prophylaxis of breast cancer in HIGH RISK pts
- osteoporosis (in older pts)
Clomiphene is indicated for
infertility
Synthetic estorgens are indicated for
ethinyl estradiol and mestranol
- hormone replacement therapy
- combined oral contraceptive
- hypogonadism (puberty aged kids)
Aromatase inhibitors Letrozole (femera) and Exemstane (aromasin) are indicated for
advance breast cancer + post menopausal (letrozole and exemestane)
aromatase inhibitor Anastrozole is indicated for
F/U treatment of advanced BC in women with disease progression + Tamoxifen
what aromatase inhibitor is indicated for ovulation induction for PCOS patients
Letrozole
what is androgen agonist Danazol indicated for?
Endometriosis and Hereditary angioedema
what is Finasteride (proscar) indicated for?
BPH and Androgenetic alopecia
what is flutamide and Bicalutamide (casodex) indicated for?
- metastatic prostate cancer + GnRH for medical castration
- Hirsutism (PCOS pts)
- Androgenic alopecia in females
what is spironolactone indicated for in reproductive use
- androgenic effects of PCOS (hirsutism)
- Androgenetic alopecia in females
what are the indications for ketoconazole
- peripheral precocious puberty (McCune-Albright syndrome)
- Cushing syndrome
- advance prostate cancer
- androgenic effects of pcos
what are the indications for progestin use?
- contraception
- abnormal uterine bleeding
- progesterone challenge test
- endometrial cancer
- endometriosis
what are the indications for antiprogestins
- termination of pregnancy
- hyperglycemia in pts with cushings
what are the indications for Ulipristal (Ella)
progestin receptor modulator
emergency contraception
uterine fibroids
what are the indications for Rhogam
Rh- mom and Rh+ baby
what are the indications for oxytocin
neuromodulation of social and reproductive behavior
* uterine contracts/labor
what birth control is safe for >35yo and smoker
IUD
what are the indications for hormonal combined contraceptives
- lighter menses
- improved dysmenorrhea
- pelvic pain 2nd to endometriosis
- decreased risk of ovarian and endometrial cancer
- acne
- ovarian cysts
- myoma risk decreases
- PCOS
- turners syndrome
what contraception is good for pts with migrain auras
progestin only pill
what are contraindications for tamoxifen
- angioedema
- warfarin therapy
- hx of dvt or PE
CI of Raloxifene
- venous thromboembolic disorders
- pregnancy
what are contraindications of clomiphene
- hypersensitivity
- liver disease
- aub
- ovarian cysts
- uncontrolled thyroid or adrenal function
- organic intracranial lesions
- pregnancy
CI for androgen agonists (Danzol)
- undiagnosed AUB
- pregnancy/breast feeding
- prorphyria (bleeding dx)
- impaired function of liver, kidney, heart
- androgen-dependent tumor
- thrombosis
