Indications & CI for Reproductive Flashcards

1
Q

Tamoxifen is indicated for

A
  • breast cancer tx
  • premenopausal estrogen receptor positive breast cancer
  • vaginal atrophy
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2
Q

Raloxifene (evista) is indicated for

A
  • prophylaxis of breast cancer in HIGH RISK pts
  • osteoporosis (in older pts)
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3
Q

Clomiphene is indicated for

A

infertility

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4
Q

Synthetic estorgens are indicated for

ethinyl estradiol and mestranol

A
  • hormone replacement therapy
  • combined oral contraceptive
  • hypogonadism (puberty aged kids)
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5
Q

Aromatase inhibitors Letrozole (femera) and Exemstane (aromasin) are indicated for

A

advance breast cancer + post menopausal (letrozole and exemestane)

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6
Q

aromatase inhibitor Anastrozole is indicated for

A

F/U treatment of advanced BC in women with disease progression + Tamoxifen

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7
Q

what aromatase inhibitor is indicated for ovulation induction for PCOS patients

A

Letrozole

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8
Q

what is androgen agonist Danazol indicated for?

A

Endometriosis and Hereditary angioedema

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9
Q

what is Finasteride (proscar) indicated for?

A

BPH and Androgenetic alopecia

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10
Q

what is flutamide and Bicalutamide (casodex) indicated for?

A
  • metastatic prostate cancer + GnRH for medical castration
  • Hirsutism (PCOS pts)
  • Androgenic alopecia in females
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11
Q

what is spironolactone indicated for in reproductive use

A
  • androgenic effects of PCOS (hirsutism)
  • Androgenetic alopecia in females
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12
Q

what are the indications for ketoconazole

A
  • peripheral precocious puberty (McCune-Albright syndrome)
  • Cushing syndrome
  • advance prostate cancer
  • androgenic effects of pcos
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13
Q

what are the indications for progestin use?

A
  • contraception
  • abnormal uterine bleeding
  • progesterone challenge test
  • endometrial cancer
  • endometriosis
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14
Q

what are the indications for antiprogestins

A
  • termination of pregnancy
  • hyperglycemia in pts with cushings
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15
Q

what are the indications for Ulipristal (Ella)

progestin receptor modulator

A

emergency contraception

uterine fibroids

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16
Q

what are the indications for Rhogam

A

Rh- mom and Rh+ baby

17
Q

what are the indications for oxytocin

A

neuromodulation of social and reproductive behavior
* uterine contracts/labor

18
Q

what birth control is safe for >35yo and smoker

A

IUD

19
Q

what are the indications for hormonal combined contraceptives

A
  • lighter menses
  • improved dysmenorrhea
  • pelvic pain 2nd to endometriosis
  • decreased risk of ovarian and endometrial cancer
  • acne
  • ovarian cysts
  • myoma risk decreases
  • PCOS
  • turners syndrome
20
Q

what contraception is good for pts with migrain auras

A

progestin only pill

21
Q

what are contraindications for tamoxifen

A
  • angioedema
  • warfarin therapy
  • hx of dvt or PE
22
Q

CI of Raloxifene

A
  • venous thromboembolic disorders
  • pregnancy
23
Q

what are contraindications of clomiphene

A
  • hypersensitivity
  • liver disease
  • aub
  • ovarian cysts
  • uncontrolled thyroid or adrenal function
  • organic intracranial lesions
  • pregnancy
24
Q

CI for androgen agonists (Danzol)

A
  • undiagnosed AUB
  • pregnancy/breast feeding
  • prorphyria (bleeding dx)
  • impaired function of liver, kidney, heart
  • androgen-dependent tumor
  • thrombosis
25
Q

what are CI of spironolactone?

A
  • hyperkalemia
  • addison’s disease
  • adrenal disease
26
Q

what are CI of Ketoconazole

A
  • gynecomastia
  • amenorrhea
  • cyp450 inhibitor
  • hepatotoxicity
  • QTc prolongation
27
Q

s

what are CI of Mifepristone (antiprogestin)

A
  • chronic adrenal failure
  • porphyrias
  • hemorrhagic dx
  • anticoagulant therpay
  • IUD in place
  • ectopic pregnacy
  • concurrent long-term corticosteroid therapy
28
Q

what are absolute CI of IUDs

A
  • pregnancy
  • PID
  • Anatomic abnormality
  • uterine bleeding
  • Wilson’s dx (copper iud)
  • cervical, endometrial, gestational trophoblastic syndrome
  • breast cancer (levongesterel)
29
Q

what are relative CI of IUD

A
  • active liver disease
  • menorrhagic/dysmenorrhea (copper)
30
Q

what are CI of nexplanon

A
  • pregnancy
  • liver disease
  • breast cancer
31
Q

what are CI of diaphragms and cervical caps?

A

use during menstrual periods

32
Q

what contraceptive should not be used with vaginal rings

A

Phexxi