MOA of Asthma Meds

Question 1

B2 Agonists

Answer 1

relax bronchial smooth muscle and induce bronchodilation
-salbutamol

Question 2

Omalizumab (monoclonal antibody)

Answer 2

inhibits the binding of IgE (thus activation of mast cells, basophils and dendritic cells)

Question 3

Mast cell stabilizers

Answer 3

block IgE receptor on mast cells preventing degranulation and histamine release
-cromolyn sodium, nedocromil

Question 4

Muscarinic antagonists

Answer 4

competitively inhibit postganglionic muscarinic receptors in bronchial smooth muscle (bronchodilation)
ipratopium bromide

Question 5

Leukotriene receptor antagonists

Answer 5

counteract the pro-inflammatory effects of leukotrienes by blocking the leukotriene receptor on bronchial smooth muscle
-montelukast

Question 6

Inhaled/oral corticosteroids

Answer 6

inhibit transcription factors resulting in anti-inflammatory effect
-beclomethasone
-prednisolone

Question 7

Zilueton

Answer 7

inhibits 5-lipoxygenase
results in reduced leukotriene production