SG Sodium Handling Flashcards

1
Q

What is the volume of the intracellular compartment?

A

28L

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2
Q

What is the volume of the interstitial space?

A

10.5L

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3
Q

What is the volume of the intravascular space?

A

3.5L

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4
Q

What can flow passively btw the intracellular space and the interstitium?

A

water

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5
Q

What can flow passively btw the interstitium and the intravascular space?

A

Na, Cl, water

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6
Q

What is found in the plasma?

A

proteins, esp albumin and IVIGs

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7
Q

If albumin is given to the patient, in which spaces will the albumin be found?

A

only w/i the intravascular space

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8
Q

If salt is given to the patient, in which spaces will the salt be found?

A

in the interstitium and the intravascular spaces

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9
Q

Which diuretic works upon the proximal convoluted tubule?

A

acetazolamide

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10
Q

Which diuretic works upon the thich ascending Loop of Henle?

A

furosemide

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11
Q

Which diuretic works upon the distal convoluted tubule?

A

thiazide, amiloride

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12
Q

Which diuretic works upon the collecting duct?

A

spironolactone, triampterone

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13
Q

How does acetazolamide work?

A

it inhibits carbonic anhydrase

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14
Q

How does furosemide work?

A

it inhibits the Na/K/Cl cotransporter

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15
Q

How do thiazide diuretics work?

A

they inhibit the Na/Cl transporter

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16
Q

How does amiloride work?

A

it inhibits ENAC

17
Q

How does spironolactone work?

A

it’s an aldosterone blocker

18
Q

How does triampterone work?

A

it’s an aldosterone blocker

19
Q

What is an important side effect of acetazolamide?

A

acidosis

20
Q

What is an important side effect of spironolactone?

A

gynecomastia

21
Q

Which is more potent: furosemide or bumetanide?

A

bumetanide (40x)