Sexual Dysfunction Flashcards
Another word for erectile dysfunction
impotence
What medications are used to treat hypoactive sexual desire disorder (HSDD)
Flibanserin (ADDYI) - can cause fainting
Bremelanotide (Vyleesi)
If sexual dysfunction is due to a SSRI or SNRI side effect, what should the patient be switched to?
Bupropion
Common causes of erectile dysfunction
HTN, atherosclerosis, diabetes
What medications can contribute to ED?
Alcohol Antidepressants (SSRIs and SNRIs) Beta blockers clonidine First-generation antipsychotics Prolactin-raising second generation Finasteride Dutasteride Silodosin
Natural products for ED
Yohimbe
L-arginine
Panax ginseng
What medication therapies are available for ED?
PDE-5 inhibitors
Alprostadil
PDE-5 inhibitor medications
Sildenafil (Viagra)
Tadalafil (Cialis)
PDE-5 inhibitor CI, Warnings, SE
CI: Do not use with nitrates or riociguat
Warnings: impaired color discrimination, hearing loss, vision loss, hypotension, priapism (seek medical attention if >4 hours), cardiovascular problems
SE: HA, flushing, dizziness, dyspepsia, back pain
PDE-5 inhibitors can potentiate antihypertensive effects of what medications?
alpha-1 blockers
Aloprostadil MOA
vasodilator that allows blood to flow into cavernosal arteries which enlarges the penis
Alprostadil administration
Injected into penis
Pellet inserted through the urethra
Filbanserin MOA
5-HT1A agonist and 5-HT2A antagonist
Flibanserin (Addya) BBW, warnings
BBW: CI with alcohol (REMS program required), combined with CYP3A4 inhibitors
Warnings: hypotension, syncope
How long to take PDE-5 inhibitors before sexual activity
Avanafil - 15 min
Tadalafil - 30 min
Sildenafil and Vardenafil - 1 hour
