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NAPLEX Review > HIV Study Notes and Key Counseling Points > Flashcards

HIV Study Notes and Key Counseling Points Flashcards

1
Q

Atripla
Generic name
Class of drugs included

A

Efavirenz/Tenofovir disoproxil fumarate/Emtricitabine
2 NRTIs + 1 NNRTI
1 pill once daily

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2
Q

Biktarvy
Generic name
Class of drugs included

A

Bictegravir/emtricitabine/tenofovir alafenamide
2 NRTIs + INSTI
1 pill once daily

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3
Q

Atripla
Efavirenz/Tenofovir disoproxil fumarate/Emtricitabine
Key counseling points

A

Take on empty stomach at bedtime
aTRIPLa has 3 drugs
Tenofovir DF has bone and renal problems

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4
Q

Biktarvy
Bictegravir/emtricitabine/tenofovir alafenamide
Key counseling points

A

INSTI - separate Al, Mg

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5
Q

Complera

Generic name

A

Rilpivirine/Tenofovir disoproxil fumarage/Emtricitabine

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6
Q

Complera
Rilpivirine/Tenofovir disoproxil fumarage/Emtricitabine
Key counseling points

A

Rilpivirine: take with water and meals (not protein drink)

Requires acidic gut for absorption; CI with PPIs, separate antacids, H2RAs

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7
Q

Delstrigo
Generic name
Class of drugs included

A

Doravirine/Tenofovir disoproxil fumarage/Lamivudine

2 NNRTI + 1 NRTI

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8
Q

Delstrigo
Doravirine/Tenofovir disoproxil fumarage/Lamivudine
Key counseling points

A

All NNRTIs can cause hepatotoxicity and rash

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9
Q

Dovato
Generic name
Class of drugs included

A

Dolutegravir/Lamivudine

1 NRTI + 1 INSTI

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10
Q

Dovato
Dolutegravir/Lamivudine
Key counseling points

A

Do not start if HIV RNA > 500,000 copies/mL or if HBV-positive

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11
Q

Genvoya

Generic name

A

Elvitegravir/Cobicistat/Tenofovir alafenamide/Emtricitabine

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12
Q

Genvoya
Elvitegravir/Cobicistat/Tenofovir alafenamide/Emtricitabine
Key counseling points

A

Take with food

CrCl <30 ml/min - do not use

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13
Q

Juluca

Generic name

A

Dolutegravir/rilpivirine

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14
Q

Juluca
Dolutegravir/rilpivirine
Key counseling points

A

Take with water and meal (rilpivirine)
Separate from Al, Mg (dolutegravir)
Must be virologically suppressed on stable ART for more than 6 months before starting (rilpivirine)

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15
Q

Odefsey

Generic name

A

Rilpivirine/Emtricitabine/Tenofovir alafenamide

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16
Q

Stribild
Generic name
Classes of drugs included

A

Elvitegravir/Cobicistat/Tenofovir disoproxil fumarate/Emtricitabine
INSTI + booster + 2 NRTI

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17
Q

Stribild
Elvitegravir/Cobicistat/Tenofovir disoproxil fumarate/Emtricitabine
Key counseling points

A

Take with food
Avoid NSAIDS
Do not use CrCl < 50

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18
Q

Difference between Stribild and Genvoya

A

Stribild has TDF

Genvoya has TAF

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19
Q

Symfi

Generic name

A

Efavirenz/TDF/Lamivudine

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20
Q

Symfi
Efavirenz/TDF/Lamivudine
Key counseling points

A

Take on empty stomach at bedtime (efavirenz)

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21
Q

Symtuza

Generic name

A

Darunavir/Cobicistat/TAF/Emtricitabine

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22
Q

Symtuza
Darunavir/Cobicistat/TAF/Emtricitabine
Key counseling points

A

Take with food (cobicistat)

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23
Q

Triumeq
Generic name
Classes of drugs included

A

Dolutegravir/Abacavir/Lamivudine

2 NRTIs + INSTI

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24
Q

Triumeq Dolutegravir/Abacavir/Lamivudine

Key counseling points

A

Test HLA-B*5701 prior to use (abacavir)

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25
Q

NRTI class SE

A

lactic acidosis, hepatomegaly with steatosis

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26
Q

Cimduo
Drug class
Generic names
Key counseling points

A

NRTI
Lamivudine/TDF
Duo of 2 NRTIs

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27
Q

Combivir
Drug class
Generic names
Key counseling points

A

NRTI
Zidovudine/Lamivudine
Food not required, but helps to reduce GI upset (zidovudine)

28
Q

Descovy
Drug class
Generic names
Key counseling points

A

NRTI
TAF/Emtricitabine
Test HLA-B*5701 prior to use (abacavir)

29
Q

Emtriva
Drug class
Generic names
Key counseling points

A

NRTI
Emtricitabine
Hyperpigmentation palms of hand/soles of feet esp in children

30
Q

What medication should not be used with emtricitabine and why?

A

Lamivudine

Both can cause HA

31
Q

Epivir
Drug class
Generic names
Key counseling points

A

NRTI
Lamivudine
Also used to treat hepatitis B virus (HBV)

32
Q

Epzicom
Drug class
Generic names
Key counseling points

A

NRTI
Abacavir/Lamivudine
Only use if negative for HLA-B*5701 (abacavir)

33
Q

Retrovir
Drug class
Generic names
Key counseling points

A

NRTI
Zidovudine
Myopathy, neutropenia, anemia, food not required but can decrease GI upset, can increase CPK

34
Q

How should you treat anemia caused by Zidovudine (Retrovir)

A

Erythropoietin

35
Q

Temixys
Drug class
Generic names

A

NRTI

TDF/Lamivudine

36
Q

Trizivir
Drug class
Generic names
Key counseling points

A

NRTI
Abacavir/Zidovudine/Lamivudine
Food not required but helps GI upset, monitor for anemia and neutropenia
Only use for negative HLA-B*5701

37
Q

Truvada
Drug class
Generic names
Key counseling points

A

NRTI
TDF/Emtricitabine
Used for PrEP and PEP

38
Q 
Didanosine
Drug class
Key counseling points
A

NRTI
Pancreatitis, severe hepatomegaly with steatosis
No alcohol

39
Q

Viread
Drug class
Generic names
Key counseling points

A

NRTI
TDF
Do not take tenofovir with didanosine and do not suddenly stop if Hep-B positive

40
Q 
Stavudine
Drug class
Key counseling points
A

NRTI

Pancreatitis, severe hepatomegaly with steatosis

41
Q

Ziagen
Drug class
Generic names
Key counseling points

A

NRTI
Abacavir
Only use if negative HLA-B*57-1
If hypersensitivity reaction, do not rechallenge

42
Q

Isentress
Drug class
Generic names
Key counseling points

A 
INSTI
Raltegravir
Preferred if taken with Descovy or Truvada
Isentress is BID
Isentress HD is once daily
43
Q

Tivicay
Drug class
Generic names
Key counseling points

A

INSTI
Dolutegravir
Preferred if taken with Descovy or Truvada
Dolutegravir might have small increase in neural tube defects, but remains preferred
Caution females with child-bearing capacity

44
Q

Edurant
Drug class
Generic names
Key counseling points

A

NNRTI
Rilpivirine
Take with water and a meal - do not replace meal with protein drink

45
Q

NNRTI class SE

A

Rash, liver damage

DYP substrates, including CYP3A4 - many drug interactions

46
Q

Intelence
Drug class
Generic names
Key counseling points

A

NNRTI
Etravirine
Take after meal

47
Q

Pifeltro
Drug class
Generic names
Key counseling points

A

NNRTI
Doravirine
If using rifabutin, take BID instead of daily

48
Q

Rescriptor
Drug class
Generic names
Key counseling points

A

NNRTI
Delavirdine
Not as bad as nevirapine for causing liver damage and rash, but still high risk

49
Q

Sustiva
Drug class
Generic names
Key counseling points

A 
NNRTI
Efavirenz
CNS effects, including abnormal dreams and confusion
Can cause depression/suicidality
CNS effect often goes away in 2-3 weeks
Take on empty stomach at bedtime
50
Q

Viramune
Drug class
Generic names
Key counseling points

A

NNRTI
Nevirapine
High risk liver damage and rash

51
Q

PI class SE

A

Metabolic abnormalities (hyperlipidemia, hyperglycemia, lipohypertrophy), hepatotoxicity, drug interactions, diarrhea, nausea

52
Q

Aptivus
Drug class
Generic names
Key counseling points

A

PI
Tipranavir
BBW for liver damage, intracranial hemorrhage
Caution with sulfa allergy

53
Q

Which antivirals contain sulfa and should be cautioned in sulfa allergy

A

Tipranavir
Darunavir
Fosamprenavir

54
Q

Crixivan
Drug class
Generic names
Key counseling points

A 
PI
Indinavir
Not used much
Kidney stones, high BG
Take on empty stomach with a light, low-fat snack
55
Q

Evotaz
Drug class
Generic names
Key counseling points

A

PI
Atazanavir/Cobicistat
Separate atazanavir from acid-suppressing drugs

56
Q

Invirase
Drug class
Generic names
Key counseling points

A

PI
Saquinavir
Not used much; QT prolongation

57
Q

Kaletra
Drug class
Generic names
Key counseling points

A 
PI
Lopinavir/Ritonavir
Take on empty stomach
Solution contains high amount of alcohol
Do not take with metronidazole, tinidazoel, disulfiram
58
Q

Lexiva
Drug class
Generic names
Key counseling points

A

PI
Fosamprenavir
Caution if sulfa allergy; take solution on an empty stomach

59
Q

Norvir
Drug class
Generic names
Key counseling points

A 
PI
Ritonavir
Take with food
Used in low booster doses
Solution is high in alcohol
60
Q

Prezcobix
Drug class
Generic names
Key counseling points

A

PI
Darunavir/Cobicistat
Take with food

61
Q

Prezista
Drug class
Generic names
Key counseling points

A 
PI
Darunavir
Take with food
Take with booster
Caution with sulfa allergy
62
Q

Reyataz
Drug class
Generic names
Key counseling points

A

PI
Atazanavir
Take with ritonavir or cobicistat
Take with food

63
Q

Viracept
Drug class
Generic names
Key counseling points

A

PI
Nelfinavir
Take with food

64
Q 
Selzentry
Drug class
Generic names
Key counseling points
A

Entry and Attachment inhibitors
Maraviroc
Requires tropism assay; must have CCR5 coreceptor type only

65
Q

Fuzeon
Drug class
Generic names
Key counseling points

A

Entry and attachment inhibitors
Enfuvirtide
SC injection, requires reconstitution, painful, rotate injection site

66
Q

Trogarzo
Drug class
Generic names
Key counseling points

A

Entry and attachment inhibitors
Ibalizumab-uiyk
monoclonal antibody, infusion related reactions
not self-administered

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