Severe combined immunodeficiency (SCID)

Question 1

What does SCID stand for?

Answer 1

Severe combined immunodeficiency

Question 2

What is SCID?

Answer 2

An inheritable disorder that prevents the maturation of B and T lymphocyte cells.
It mainly occurs in arabs (Scott et al, 1999)

Question 3

When do signs start to show?

Answer 3

Generally foals appear normal at birth, and the first sign of the disorder can be seen withing 2 days of birth. Foals at birth already have a lowered IS, therefore with SCID it generally doesn’t develop further.

Question 4

How would you diagnose SCID?

Answer 4

• Blood lymphocyte tests
• Hb & Ig counts
• Hypolasia of lymph nodes PM (normally see thay are under developed)

Question 5

What symptoms do you see with SCID?

Answer 5

Generally you see generic symptoms

• Jaundice
• Increased HR
• Fever
• Diarrhoea

Question 6

How do you treat SCID?

Answer 6

Bacterial Ab’s
Bone marrow transplants
Blood transfusions

Question 7

What is the prognosis with SCID?

Answer 7

Always fatal- 100% mortality and usually die by 5 months of age (McClure 1997)
Euthanism is usually recommend as they dont/ cant survive.