Session 15 - Respiratory III Flashcards
What organisms tend to cause bronchopneumonia?
Bacteria
What organisms tend to cause interstitial pneumonia?
Viral
What is the major cause of shipping fever in cattle?
Mannheimia hemolytica
What organisms can occur in a co-infection with Mannheimia hemolytica in shipping fever?
BoHV-1
PI-3
Pasteurella multocida
Histophilus somni
What is the pathologic mechanism of shipping fever?
Production of virulence factors
Kills bovine macrophages and neutrophils
Acute inflammation
What is the main virulence factor in Mannheimia hemolytica that causes a lot of damage?
Leukotoxin
What lesions are seen with Manneheimia hemolytica in cattle?
Severe bronchopneumonia
Tissue necrosis
Alveolar hyperemia + hemorrhage
Alveoli filled with suppurative inflammation
Wide interlobular septa expanded by edema + fibrin
What are the molecules that are responsible for the acute inflammation seen in shipping fever? (five listed)
TNF-alpha IL-1 IL-8 Histamine Leukotrines
What is the difference in presentation between Mannheimia hemolytica and Histophilus somni?
HS will commonly spread to other parts of the body
What are organ systems that tend be targets for Histophilus somni? What does it cause there?
Myocarditis - heart Arthritis - joints Opthalitis - eyes Otitis - ears Abortion - Fetus Encephalitis - Brain Septicemia - Blood
What are COMMON things seen in cattle with a histophilus somni infection?
Pneumonia + Pleuritis
What are the four common animals affected by pasteurella multocida?
Cows + Pigs + Rabbits + Cats
What is the presentation of pasteurella multocida in cattle?
Co-infection with shipping fever
What is the presentation of pasteurella multocida in pigs?
Fibrinous bronchopneumonia
What is the presentation of pasteurella multocida in rabbits?
Pleuropneumonia
Snuffles
Otitis
Bacteremia
Where does pasteurella multocida tend to colonize in rabbits?
Nares
What is the presentation of pasteurella multocida in cats?
Pyothorax
What is a bacteria that can cause pasteurellosis in sheep?
Bibersteinia trehalosi
What is an important virulence factor that is secreted by Bibersteinia trehalosi?
Leukotoxin
What can cause porcine pleuropneumonia?
Actinobacillus pleuropneumoniae
How does actinobacillus pleuropneumoniae present in young pigs?
Septicemia
How does actinobacillus pleuropneumoniae present in weaned pigs?
Otitis interna
What can Arcanobacterium pyogenes cause? What animal?
Ruminants - Septic pulmonary emboli
What can Corynebacterium Pseudotuberculosis cause? What animal?
Sheep/Goat - Caseous lymphadenitis
What is the pathologic mechanism of Corynebacterium Pseudotuberculosis?
Bacteria introduced via inhalation/penetration
Macrophages take up take to LN
Forms pyogranumolomas
Where are common areas to see pyogranumolomas caused by Corynebacterium Pseudotuberculosis?
LN + Lungs + Subcutis
Where on the body is mycobacterium commonly found?
Mucosal surface of:
Respiratory + Urogenital tracts
What are the bacterial characteristics of Mycobacterium?
Acid-fast, no cell wall
What are the Mycoplasmas listed?
M. Bovis
M. Mycoides ssp. mycocides
M. Hyopneumoniae
What does Mycoplasma Bovis cause?
Chronic, necrotizing bronchopneumonia
With suppurative/caseated abscesses
What does a successful infection by Mycoplasma Bovis require?
Immunosuppression
What does the gross appearance of a lesion from Mycoplasma Bovis look like?
Necrosis centered around bronchi + bronchioles
What are other places, besides the lungs, that Mycoplasma Bovis can spread?
Mastitis Arthritis Otitis Keratoconjunctivitis Abortion
What is important to note about Mycoplasma Mycoides ssp. Mycoides
Reportable foreign animal disease in the US
What is a differential for Mycoplasma Mycoides ssp. Mycoides?
Mannheimia Hemolytica
What pathology is seen with Mycoplasma Mycoides ssp. Mycoides?
Severe pleuropneumonia
How can you tell a M. Mycoides infection from M. hemolytica?
MM - has a more caudal distribution
Sequela of necrotic lung due to vascular thrombosis
Wider expansion of interlobular seta
What does Mycoplasma hyopneumonia cause?
Porcine enzoonotic pneumonia
What is the pathologic presentation of Porcine enzoonotic pneumonia?
Suppurative + Catarrhal bronchopneumonia
What can make a pig susceptible to a Mycoplasma Hyopneumoniae infection?
Ammonia + Hydrogen sulfide gases
Along with other stressors
How can streptococcus suis be transmitted?
Oral
Aerogenous
Vertically to fetus
What pathologic presentations are going to present with a Streptococcus suis infection?
Bronchopneumonia Polyarthritis Polyserositis Abortion Neonatal septicemia Meningitis
What is important to remember as a vet if dealing with cattle that could possibly be infected with Streptococcus suis infection?
Zoonotic
Can cause meningitis and septic shock in humans
What are the hemolytic species of Streptococcus?
Canis + Equi + Zooepidemicus
What do the hemolytic species of Streptococcus tend to cause in small animals?
Bronchopneumonia + Septicemia + Placentitis + Dermatitis
What co-infections can occur with Streptococcus infections in small animals?
Pasteurella Multocida
E. Coli
Klebsiella pneumoniae
Bordetella bronchiseptica
What can cause a streptococcus infection in a small animal that is caused by us?
dentals
What does Streptococcus zooepidemicus cause in dogs?
Acute, hemorrhagic pleuropneumonia
What does a Streptococcus zooepidemicus infection look like grossly in a dog?
Diffuse pulmonary hemorrhage
Necrosuppurative exduate with hemorrhagic pleural effusion
What normally is the cause of death with Streptococcus zooepidemicus, even though rare?
Septicemic shock
What are the two systems affected by Rhodococcus equi?
Respiratory + Intestinal
What is seen in the respiratory systems with a Rhodococcus equi infection?
Severe granulomatous bronchopneumonia
What is seen in the intestinal tract with a Rhodococcus equi infection?
Ulcerative enterocolitis
What is the source for Rhodococcus equi?
Soil + Feces
What is the pathologic mechanism for Rhodococcus equi?
Alveolar macrophages uptake bacteria
Bacteria multiply and rupture macrophages
Lysosomal enzymes released
Neutrophils response –> inflammatory cytokines released
Tissue damage = Acute pyogranuloma
What are the two end results of a Rhodococcus equi infection?
Bronchopneumonia = death
Chronic caseous pneumonia
What is the cause of Bovine tuberculosis
Mycobacterium bovis
What is the pathologic mechanism of Mycobacterium bovis?
Alveolar macrophages take up bacteria Bacteria multiply and rupture macrophage Apread with in the lung Lymphatic invasion = Lymphadenitis Wide spread dissemination
What are the major pathologies seen with Mycobacterium bovis?
Chronic, granulomatous pneumonia
Lymphadenitis
What is important to remember as a vet if dealing with cattle that have a possible Mycobacterium bovis infection?
Zoonotic - transferred via contaminated milk + Aerosolization
What are the wildlife hosts of Mycobacterium bovis? Where?
US - Deer
UK - Badgers
What are animals can be infected by Bordetella bronchiseptica?
Dogs + Pigs + Cats + Rodents
What can Bordetella Bronchiseptica cause in pigs?
Atrophic Rhinitis
What are the symptoms seen in kennel cough?
Harsh cough that can be productive or non-productive
What is a common viral cause of equine viral pneumonia?
EHV 1,4
What is EVA?
Equine viral arteritis
What is the is the viral target in EVA?
Endothelial cells + Macrophages
What are the symptoms area seen with EVA?
Fever Diarrhea Colic Respiratory Distress Ventral abdominal/limb edema
What gross lesions are seen with EVA?
Multifocal hemorrhage + interstitial pneumonia
What is seen histologically with EVA?
Fibrinoid necrosis of small arterial walls Vasculitis/arteriolitis Edema + Hemorrhage Thickening of interstitium Type II pneumocyte hyperplasia
What is the pathologic mechanism for Canine Distemper?
Virus moves from conjunctiva or oral/nasal to tonsils
Moves through body via lymphatics