Session 13,14 - Respiratory I + II Flashcards
Three routes into the lung
Aerogenous
Hematogenous
Direct extension
What tends to enter the lung aerogenously?
Infectious pathogens + Toxins
What tends to affect the lungs through a hematogenous mechanism?
Speticemia
Bacteremia
Parasites
Neoplasia
What is involved in the direct extension mechanism of lung routes?
Bites
Penatrating wounds
Migrating FB’s
Neoplasia
Where do particles larger then 2 um tend to get stuck?
Nasal Turbinates + Tracheal/Bronchial bifurcations
What are the methods of clearance in the upper respiratory tract (URT)?
Destruction + Neutralization + Removal
What are the four ways the lungs can remove things from the airway?
Sneezing + Coughing + Phagocytosis + Mucociliary transport
Where is the mucociliary transport present in the airways?
Bronchi to Pharynx
What are the layers of the mucous within the URT?
Gel + Sol
What cells produce the mucous in the URT?
Goblet + Serous + Submucosal
What are the cell-associated defenses within the nose, trachea, and bronchi (aka URT)?
AB’s + Lysozymes + Mucus
What are the cell-associated defenses within the bronchioles?
Clara cells + Antioxidants + Lysozymes + Antibodies
What is a special structure that is present in the bronchial bifurcations?
APC’s
Where do the APC’s take the inhaled particles they come across at the bronchial bifurcations?
BALT
What is BALT?
Bronchial associated lymphoid tissue
What are clara cells?
Non-ciliated cells present only in the bronchioles
What are the functions of the clara cells?
Cytokine inhibitor
Produce antibacterial + Antioxidant molecules
Surfactant production
Secretion of mixed function oxidase-containing granules
What can be a problem associated with clara cells?
Create toxic metabolites that can damage the bronchiolar epithelium and therefore create an environment for a secondary infection
What are three bovine viruses that allow for viral-bacterial synergism?
BHV-1 + PI-3 + BRSV
What is a common canine virus that allows for viral-bacterial synergism?
Canine distemper virus
What are two feline viruses that allow for viral bacterial synergism?
Feline herpesvirus + Feline calicivirus
What are two gases that tend to causes damage to the respiratory defenses?
Ammonia + Hydrogen sulfide
What are some sequela that occur when regional structures allow chronic rhinitis and sinusitis to spread to other areas?
Septal deviation
Osteomyelitis
Meningitis
Otitis media/interna
What is does catarrhal describe?
Exduate that forms on surfaces
Will be irregular and tan
Viscous + Necrotic material that is often mucopurulent
What are two common nasal parasites?
Oestrus ovis
Cuterebra spp.
What animal does Oestrus ovis tend to infect?
Sheep
How do Oestrus ovis tend to develop?
In the nostrils then maggots will migrate into the sinuses
What pathology is seen with a Oestrus Ovis infection?
Mucopurulent rhinitis + Sinusitis
What animals does Cuterebra spp. tend to infect?
Rabbits + Rodents + Cats
What Equine Influenza type is most severe?
Type A
What are common symptoms seen with Equine Influenza Type A?
Nasal discharge + Fever + Conjunctivitis
What happens with serious infections caused by Equine Influnenza Type A?
Pneumonia
Bronchointerstitial penumonia
What does Pneumonia caused by equine influenza type A suggest?
The horse is immunocompromised
What are the two equine herpes viruses that cause viral rhinopneumonitis?
1 + 4
What is seen in fowls with EHV-1,4 infections?
Mild respiratory disease
What are severe pathologies that can occur with EHV-1,4 infections?
Myeloencephalopathy
Mare abortions
Where can the herpes virus remain latent in the body?
Trigeminal ganglia
What is strangles caused by?
Streptococcus equi ssp. equi
What age is strangles most commonly seen?
Young horses
What lymph nodes are affected in strangles?
Mandibular + Retropharyngeal
What symptoms are seen with strangles?
Suppurative rhinitis, nasal discharge
Lymphadenitis
Cough
Conjunctivitis
What happens when there is hematogenous spread of strangles?
Bastard strangles - goes to other organs
What are common sequela seen with strangles?
Bronchopneumonia
Nerve compression
Purpura hemorrhagica
Guttural pouch empyema
What two nerves can be affected by strangles?
Recurrent laryngeal + Sympathetic nerve
What is the effects of the compressed sympathetic nerve in strangles?
Facial paralysis + Horner’s
What is the triad in horner’s?
Miosis + Partial ptosis + Loss of hemifacial sweating
What causes purapura hemorrhagica?
Step. Equi Ag/Ab complexes form in small vessels of the skin and mucosa
What can Bovine herpesvirus 1 (BoHV-1) cause?
Infectious bovine rhinotracheitis
What are the pathogens that can cause porcine atrophic rhinitis?
Bordetella bronchoseptica
Pasteurella multocida
Haemophilus parasuis
Porcine cytomegalovirus
What causes porcine atropic rhinitis?
increased osteoclastic activity and osteopenia due to the pathogen present leading to the loss of nasal conchae
What causes bovine necrotic laryngitis?
Fusobacterium necrophorum
What are the possible outcomes of bovine necrotic laryngitis?
Endotoxemia +/- Bacteremia
Laryngeal Obstruction
Aspiration
What causes infectious laryngotracheitis of chickens?
Herpes virus