Sensory: vision Flashcards
How many different opsins can the cones express, and how do they differ?
Three: OPN1SW (short waves=blue), OPN1MW (midlength waves=green), OPN1LW (long waves=red)
What is the function of rods and cones?
Rods: spatial resolution, more light sensitive
Cones: colour vision
What does the retinal molecules bind to?
Opsin
Describe the signaling pathway in cilliary photoreceptors
Photon stimulates the conversion of 11-cis-retinal bound to the opsin to all-trans-retinal –> release of retinal, and activation of the opsin receptor. Opsin is coupled to a Gt protein, and by activation the G_alpha is released from G-beta-gamma. G-alpha activates PDE –> reduction of cGMP –> inhibition of CNG Na+ channel –> inhibition of Ca^2+ influx (and AP) –> inhibition of glutamine release
How is the signal inhibited in cilliary cells, and when does this happen?
GRK1 phosphorylates opsin –> inactivation of opsin –> increase of cGMP –> increase of Ca^2+ –> depolarization of Vm –> release of glutamate
During darkness
What does the dynamic range of an eye refer to and how is it controlled in the human eye?
The number of photons the rods and cones can absorb depending on the brightness of a habitat.
It’s controlled by the number of active opsins in the retina (called adaptation), by controlling the process of conversion all-trans-retinal to 11-cis-retinal.
What is the lens involved in?
Accomodation: making sure the resolution matches the distance by contracting or extending the lens. Near/long sigthness is caused by a flaw in this mechanism.
What is the fovea?
Cones lined in the back of the eye directly in line with the lens (in the centre of the optical axis of the eye) not covered by any other cells –> no interference. It is packed densely with cone cells.
How does the pupil dialate, and which neuronss innervate the muscles responsible for this?
The radially smooth muscles of the iris (the dialator pupillae) contract, dialating the pupil. The dialator pupillae are innervated by adrenergic, sympathetic neurons
How does the pupil constrict, and which neuronss innervate the muscles responsible for this?
The circular smooth muscles of the iris (the sphincter pupillae) contract, constricting the pupil. The sphincter pupillae are innervated by cholinergic, parasympathetic neurons.
How many layers is the retina consisting?
3 layer: rods and cones in the back, bipolar, horizontal and amacrine cells in the middel and retinal ganglion cells in the front (+ ipRGCs)
Describe a rod cell.
Glutamatergic, rod-shaped neuron containing discs. Discs are organels lined with rhodopsin. The ros are depolarized in the darkness, and hyperpolarized in the light.
What is rhodopsin?
GPCR of the rods (opsin), with a bound retinal molecule (11´cis-retinal). They are light activated. When light hits the retinal, it converts from 11´cis- to all-trans-retinal, pushing the TM regions of the opsin. This configuration change activates the GPCR. Rhodopsin is tranducin coupled.
What are ipRGCs involved in?
The circadian rhytm and pupillary light reflexes.
Which regions of the brain does ipRGCs and rod cells project to, respectively.
ipGRCs project to the non-image forming center, the pineal gland (RHT -> suprachiasmatic nucleus -> paraventricular nucleus -> spinal cord -> SCG -> pineal gland).
Rod cells project to the image-forming center, the primary visual cortex (through the nucleus geniculatus).