Regulation of food intake

Question 1

How many percentage is it estimated that genetic varience play a role in body weight?

Answer 1

40-60 %

Question 2

Describe how genetics and environment are thought to contribute to body weight.

Answer 2

“genetics loads the gun, but the environment pulls the trigger”

Question 3

What signals from the periphery influences food intake?

Answer 3

Endocrine and NS

Question 4

What brain region are involved in sensing these signals?

Answer 4

The hypothalamus

Question 5

What brain region are part of the homeostatic regulation of food intake?

Answer 5

The brain stem

Question 6

Describe how and which some gut peptides regulate food intake.

Answer 6

stretch of stomach + nutrients in GIT –> release of CCK (gutpeptide, satiety signal) –> brainstem –> decrease food intake

Question 7

Describe the homeostatic and hedonic (food reward) circuits.

Answer 7

hypothalamus (LHA) –> striatum (VTA) –> thalamus (NAc) –> hypothalamus (LHA)

Question 8

What are ghrelin?

Answer 8

A food intake stimulating hormone

Question 9

What are GLP-1?

Answer 9

An appetite reducing hormone secreted by the gut

Question 10

What is ozempic?

Answer 10

• A diabetes drug, also used as a weight loss drug
• Targeting GLP-1-Rs
• Anti-rewarding drug

Question 11

What are tirzepatide?

Answer 11

• obesity drug
• anti-rewarding drug
• GIP/GLP-1 co-agonist