Seb Derm... Flashcards
Pityriasis sicca
Dandruff
Seb-derm like eruptions
UL nerve injury causes UL eruption, AIDS, diabetes, malabsorption, epilepsy, neuroleptic drugs like haloperidol, arsenic, gold
Pathogenesis of seb derm
Upregulation of IFN gamma, IL6, IL1beta, IL4
Expression of cytotoxicity activating ligand and recruitment of NK cells
More severe=increased density of yeast
Effective in seb derm in HIV
Lithium succinate ointment
Salmon patches
Nailbed psoriasis
Highly suggestive radio graphic PSO findings
Acrosteatolysis - erosions of terminal phalangeal tufts
Tapering
Pencil in cup - cupping of distal phalanges
Predilection for DIP and PIP with sparing of mcp
Generalized pustular PSO
Mucous membrane and RDS may occur
Presenting sign of Cushings
Drugs:iodides, tar, mino, terbinafine hydroxychloroquine, acetazolamide, salicylate
Late onset PSO
Cw2
Palmoplantar PSO
HLA-B8, Bw35, Cw7, DR3
PSO associations
Hep C, celiac, lymphoma
Promotes IFN gamma
IL-12
PSO patho physiology
Reduced IL-10 and IL-1RA
Polymorphisms in IL-10
Rising levels of IL-10 mRNA on therapy
IL-15 triggers inflammatory cell recruitment, angiogenesis, IFN gamma, TNF alpha, IL-17 (proinflammatory)
IL-23 stimulates survival and proliferation of TH17
IL-22 retard keratinocytes differentiation
PSO DIF
SC flueoresces with all ab, fibrin, and Cā
*same for some candidiasis
Salycilate toxicity
Tinnitus, confusion, refractory hypoglycemia; especially in DM and renal
Monitoring of mtx liver fibrosis
Procollagen III
