Epidermal Nevi Flashcards
Keratinocytic epidermal nevi
Involve the SC and stratum malpighii PI3K, FGFR3 FOXN1 highly expressed Large lesions of trunk more frequently associated with skeletal 5FU plus 0.1% tretinoin once daily
Nevus comidonicus
EEG Abn, IL cataracts and skeletal
FGFR2 (like aperts)
Garcia hafner happle
Velvety nonepidermolytic EN
Cerebral defects
fGFR3
Nevus trichilemmocysticus
Multiple blaschkoid pilaf cysts
Osteomalacia and fractures
Didymosis aplasticosebacea
Nevus sebaceous + ACC in close proximity
SCALP
Seb Nevus, CNS malf, ACC, limbal dermoid and pigmented nevus
Gobellos syndrome
Systematized velvety orthokeratotic nevus with hypertrichosis and follicular hyperkeratosis
Bafverstedt syndrome
Horny excrescences ina linear pattern with MR and sz
Diffuse ichthyosis like hyperkeratosis of the entire body
NEVADA
Keratinocytic verrucous epi nevus with angiodysplasia
Hyperkeratosis of the nipple and areola
GVHD
AN
Mucocutaneous candidiasis
Sorafenib
High risk of SCC and Bowens from arsenic exposure to what
Well water
If from elixirs then higher risk of BCC - latency of 20 years, MC on the scalp
MC site for cutaneous horn
Dorsal hands and scalp
May overlie an sk, molluscum, VV, angiokeratoma or trichilemmoma
20% overlie SKs, 20% SCC and 60% benign
KA may be seen
With trauma, hypertrophic LP, DLE, tattoos, fraxel, imiquimod, surgical excisions
Subungual KA
Don’t regress
Show crescent shaped lytic defect of underlying bone without sclerosis or periosteum rxn
Most definitive histologic finding of KAs
Terminal differentiation where the scalloped border of the tumor has lost its infiltrative characteristics and is reduced to a thin rim of keratinizing cells
When to excise KAs
When there is not at least 50% involution over 3 weeks
BCC
Intermittent sun exposure
With 1 BCC what is the risk of another in the next 3 years
44%
Pt with BCC have a higher rate malignancy
Breast, testicular, and especially NHL
BCCs arise from
Hair follicle
Topical tx of superficial BCC
80%, treat for 6 weeks
Other mutation in gorlins
SUFU with incr susceptibility to meduloblastoma
SCC associated with HPV
16, 18, 35, 31
MC location of EM pagets
Vulva
Risk of underlying malignancy in EMPD
35% (vs 95% in pagets of breast)
RCAS1 can be used to monitor invasive dz
Hypophasphatemic rickets in epidermal Nevus syndrome
Elevated FGF-23 and MEPE
Syringomas
Stain for K5,6,14,16,19,77 on the inner cell layer
K5 and 14 on the outer cell layer
Hidrocystomas
Topical atropine or scopolamine cream
Syringofibroadenoma (acrosyringeal Nevus of weeden and Lewis)
Hidrotic ectodermal dysplasia
HPV10 has been detected in tumors
Mucinous carcinoma
Derived from gland of moll
Express E and progesterone R
Curry jones syndrome
Streaky hypopigmentation, hyperpigmented atrophic lines on the soles, multiple trichiblastomas, musculoskeletal, GI, ocular
Basaloid follicular hamartoma
Generalized cases associated with alopecia, myasthenia gravis
Familial AD dominant form with multiple milia
Happle tinschert
Segmental BFH, linear atrophoderma with hypo and hyperpig, IL hypertrichosis, enamel defects
EIC of sole
Associated with HPV 60
Proliferating pilar cyst
Express K7
If malignant express CD34
Eruptive vellus hair cysts
Ectodermal dysplasia
Lowe syndrome
Chronic renal failure
Drug induced multiple milia
Cyclosporine and 5FU
Also naegeli-franceschetti, generalized basilar follicular hamartoma syndrome, gorlins, atrichia with papules, PC type 2, Rombo, BRooke spiegler and basex
Milia
Derived from infundibulum
Milia en plaque
Mino may tx
Auricular pseudocyst
Atopic dermatitis and systemic lymphoma, heavy shoulder carrying, headphones etc
MC congenital neck anomaly in children
Thyroglossal duct cyst
