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Dermatology > Epidermal Nevi > Flashcards

Epidermal Nevi Flashcards

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Dermatology Board Prep flashcards
1
Q

Keratinocytic epidermal nevi

A 
Involve the SC and stratum malpighii
PI3K, FGFR3
FOXN1 highly expressed
Large lesions of trunk more frequently associated with skeletal
5FU plus 0.1% tretinoin once daily
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2
Q

Nevus comidonicus

A

EEG Abn, IL cataracts and skeletal

FGFR2 (like aperts)

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3
Q

Garcia hafner happle

A

Velvety nonepidermolytic EN
Cerebral defects
fGFR3

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4
Q

Nevus trichilemmocysticus

A

Multiple blaschkoid pilaf cysts

Osteomalacia and fractures

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5
Q

Didymosis aplasticosebacea

A

Nevus sebaceous + ACC in close proximity

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6
Q

SCALP

A

Seb Nevus, CNS malf, ACC, limbal dermoid and pigmented nevus

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7
Q

Gobellos syndrome

A

Systematized velvety orthokeratotic nevus with hypertrichosis and follicular hyperkeratosis

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8
Q

Bafverstedt syndrome

A

Horny excrescences ina linear pattern with MR and sz

Diffuse ichthyosis like hyperkeratosis of the entire body

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9
Q

NEVADA

A

Keratinocytic verrucous epi nevus with angiodysplasia

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10
Q

Hyperkeratosis of the nipple and areola

A

GVHD
AN
Mucocutaneous candidiasis
Sorafenib

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11
Q

High risk of SCC and Bowens from arsenic exposure to what

A

Well water

If from elixirs then higher risk of BCC - latency of 20 years, MC on the scalp

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12
Q

MC site for cutaneous horn

A

Dorsal hands and scalp
May overlie an sk, molluscum, VV, angiokeratoma or trichilemmoma

20% overlie SKs, 20% SCC and 60% benign

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13
Q

KA may be seen

A

With trauma, hypertrophic LP, DLE, tattoos, fraxel, imiquimod, surgical excisions

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14
Q

Subungual KA

A

Don’t regress

Show crescent shaped lytic defect of underlying bone without sclerosis or periosteum rxn

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15
Q

Most definitive histologic finding of KAs

A

Terminal differentiation where the scalloped border of the tumor has lost its infiltrative characteristics and is reduced to a thin rim of keratinizing cells

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16
Q

When to excise KAs

A

When there is not at least 50% involution over 3 weeks

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17
Q

BCC

A

Intermittent sun exposure

18
Q

With 1 BCC what is the risk of another in the next 3 years

A

44%

19
Q

Pt with BCC have a higher rate malignancy

A

Breast, testicular, and especially NHL

20
Q

BCCs arise from

A

Hair follicle

21
Q

Topical tx of superficial BCC

A

80%, treat for 6 weeks

22
Q

Other mutation in gorlins

A

SUFU with incr susceptibility to meduloblastoma

23
Q

SCC associated with HPV

A

16, 18, 35, 31

24
Q

MC location of EM pagets

A

Vulva

25
Q

Risk of underlying malignancy in EMPD

A

35% (vs 95% in pagets of breast)

RCAS1 can be used to monitor invasive dz

26
Q

Hypophasphatemic rickets in epidermal Nevus syndrome

A

Elevated FGF-23 and MEPE

27
Q

Syringomas

A

Stain for K5,6,14,16,19,77 on the inner cell layer

K5 and 14 on the outer cell layer

28
Q

Hidrocystomas

A

Topical atropine or scopolamine cream

29
Q

Syringofibroadenoma (acrosyringeal Nevus of weeden and Lewis)

A

Hidrotic ectodermal dysplasia

HPV10 has been detected in tumors

30
Q

Mucinous carcinoma

A

Derived from gland of moll

Express E and progesterone R

31
Q

Curry jones syndrome

A

Streaky hypopigmentation, hyperpigmented atrophic lines on the soles, multiple trichiblastomas, musculoskeletal, GI, ocular

32
Q

Basaloid follicular hamartoma

A

Generalized cases associated with alopecia, myasthenia gravis

Familial AD dominant form with multiple milia

33
Q

Happle tinschert

A

Segmental BFH, linear atrophoderma with hypo and hyperpig, IL hypertrichosis, enamel defects

34
Q

EIC of sole

A

Associated with HPV 60

35
Q

Proliferating pilar cyst

A

Express K7

If malignant express CD34

36
Q

Eruptive vellus hair cysts

A

Ectodermal dysplasia
Lowe syndrome
Chronic renal failure

37
Q

Drug induced multiple milia

A

Cyclosporine and 5FU

Also naegeli-franceschetti, generalized basilar follicular hamartoma syndrome, gorlins, atrichia with papules, PC type 2, Rombo, BRooke spiegler and basex

38
Q

Milia

A

Derived from infundibulum

39
Q

Milia en plaque

A

Mino may tx

40
Q

Auricular pseudocyst

A

Atopic dermatitis and systemic lymphoma, heavy shoulder carrying, headphones etc

41
Q

MC congenital neck anomaly in children

A

Thyroglossal duct cyst

Dermatology (28 decks)

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