Epidermal Nevi

Question 1

Keratinocytic epidermal nevi

Answer 1

Involve the SC and stratum malpighii
PI3K, FGFR3
FOXN1 highly expressed
Large lesions of trunk more frequently associated with skeletal
5FU plus 0.1% tretinoin once daily

Question 2

Nevus comidonicus

Answer 2

EEG Abn, IL cataracts and skeletal

FGFR2 (like aperts)

Question 3

Garcia hafner happle

Answer 3

Velvety nonepidermolytic EN
Cerebral defects
fGFR3

Question 4

Nevus trichilemmocysticus

Answer 4

Multiple blaschkoid pilaf cysts

Osteomalacia and fractures

Question 5

Didymosis aplasticosebacea

Answer 5

Nevus sebaceous + ACC in close proximity

Question 6

SCALP

Answer 6

Seb Nevus, CNS malf, ACC, limbal dermoid and pigmented nevus

Question 7

Gobellos syndrome

Answer 7

Systematized velvety orthokeratotic nevus with hypertrichosis and follicular hyperkeratosis

Question 8

Bafverstedt syndrome

Answer 8

Horny excrescences ina linear pattern with MR and sz

Diffuse ichthyosis like hyperkeratosis of the entire body

Question 9

NEVADA

Answer 9

Keratinocytic verrucous epi nevus with angiodysplasia

Question 10

Hyperkeratosis of the nipple and areola

Answer 10

GVHD
AN
Mucocutaneous candidiasis
Sorafenib

Question 11

High risk of SCC and Bowens from arsenic exposure to what

Answer 11

Well water

If from elixirs then higher risk of BCC - latency of 20 years, MC on the scalp

Question 12

MC site for cutaneous horn

Answer 12

Dorsal hands and scalp
May overlie an sk, molluscum, VV, angiokeratoma or trichilemmoma

20% overlie SKs, 20% SCC and 60% benign

Question 13

KA may be seen

Answer 13

With trauma, hypertrophic LP, DLE, tattoos, fraxel, imiquimod, surgical excisions

Question 14

Subungual KA

Answer 14

Don’t regress

Show crescent shaped lytic defect of underlying bone without sclerosis or periosteum rxn

Question 15

Most definitive histologic finding of KAs

Answer 15

Terminal differentiation where the scalloped border of the tumor has lost its infiltrative characteristics and is reduced to a thin rim of keratinizing cells

Question 16

When to excise KAs

Answer 16

When there is not at least 50% involution over 3 weeks

Question 17

BCC

Answer 17

Intermittent sun exposure

Question 18

With 1 BCC what is the risk of another in the next 3 years

Answer 18

44%

Question 19

Pt with BCC have a higher rate malignancy

Answer 19

Breast, testicular, and especially NHL

Question 20

BCCs arise from

Answer 20

Hair follicle

Question 21

Topical tx of superficial BCC

Answer 21

80%, treat for 6 weeks

Question 22

Other mutation in gorlins

Answer 22

SUFU with incr susceptibility to meduloblastoma

Question 23

SCC associated with HPV

Answer 23

16, 18, 35, 31

Question 24

MC location of EM pagets

Answer 24

Vulva

Question 25

Risk of underlying malignancy in EMPD

Answer 25

35% (vs 95% in pagets of breast) RCAS1 can be used to monitor invasive dz

Question 26

Hypophasphatemic rickets in epidermal Nevus syndrome

Answer 26

Elevated FGF-23 and MEPE

Question 27

Syringomas

Answer 27

Stain for K5,6,14,16,19,77 on the inner cell layer | K5 and 14 on the outer cell layer

Question 28

Hidrocystomas

Answer 28

Topical atropine or scopolamine cream

Question 29

Syringofibroadenoma (acrosyringeal Nevus of weeden and Lewis)

Answer 29

Hidrotic ectodermal dysplasia | HPV10 has been detected in tumors

Question 30

Mucinous carcinoma

Answer 30

Derived from gland of moll | Express E and progesterone R

Question 31

Curry jones syndrome

Answer 31

Streaky hypopigmentation, hyperpigmented atrophic lines on the soles, multiple trichiblastomas, musculoskeletal, GI, ocular

Question 32

Basaloid follicular hamartoma

Answer 32

Generalized cases associated with alopecia, myasthenia gravis Familial AD dominant form with multiple milia

Question 33

Happle tinschert

Answer 33

Segmental BFH, linear atrophoderma with hypo and hyperpig, IL hypertrichosis, enamel defects

Question 34

EIC of sole

Answer 34

Associated with HPV 60

Question 35

Proliferating pilar cyst

Answer 35

Express K7 | If malignant express CD34

Question 36

Eruptive vellus hair cysts

Answer 36

Ectodermal dysplasia Lowe syndrome Chronic renal failure

Question 37

Drug induced multiple milia

Answer 37

Cyclosporine and 5FU Also naegeli-franceschetti, generalized basilar follicular hamartoma syndrome, gorlins, atrichia with papules, PC type 2, Rombo, BRooke spiegler and basex

Question 38

Milia

Answer 38

Derived from infundibulum

Question 39

Milia en plaque

Answer 39

Mino may tx

Question 40

Auricular pseudocyst

Answer 40

Atopic dermatitis and systemic lymphoma, heavy shoulder carrying, headphones etc

Question 41

MC congenital neck anomaly in children

Answer 41

Thyroglossal duct cyst