Melanocytic Neoplams

Question 1

Multiple lentigines present after clearing of

Answer 1

Plaque PSO

Question 2

Centofacial lentiginosus

Answer 2

Status dysraphicus, musc, CNS

Central face also seen in carney

Question 3

Halo nevi

Answer 3

Reported during infliximab therapy

Question 4

Animal type melanoma

Answer 4

Low nuclear expression glutathione s transferase

Question 5

MC melanoma

Answer 5

Lentigo maligna

Question 6

Melanoma

Answer 6

Melanomas tend to have Abn in chromosome 9, 10, 7 and 6

Acral melanoma - 5p, 11q, 12q, 15

LM melanoma - loss of 17p and 13q
Spitz - gain in 11

Question 7

Single most prognostic factor in melanomas

Answer 7

LN involvement

Tumor thickness and ulceration are independent predictors of lymph nodes mets

LDH not at screening tool but prognostic factor - LDH and CXR for stage IIIA

For stage IV pelvic CT, MRI or PET

Question 8

Mongolian spot

Answer 8

PP, sjogren Larson, hunter, trisomy 20

Question 9

Laser for Mongolian spot

Answer 9

Q switched ruby and nd yang