Lymphoma Stuff Flashcards
PMLE
CD8
MC cell in MF
T helper
MC COD in MF
Sepsis
Prognostic factors in MF
LAD, tumors, ulceration
If all 3 median survival is 1 yr
MF may manifest with
TNF inh
Incr risk of MF
AD
MF markers
Cutaneous lymphocyte ag (CLA) - E selectin ligand, allows traffic into skin
CCR4, another homing molecule
Incr APCs and incr capacity to + T cells
Th1 pattern
more CD8 in early lesions to fight off - more than 20% CD8 in MF have impr survival
Sezary is Th2 which reduces th fxn = incr infection and 2’ CA
Low hhv8 has been detected
Cd4+, cd7-, cd26-
Forodesine
Inh of purine nucleoside phosphorylase
Pralatrexate - antifolate
Zanolimumab
Anti cd4 used in sezary
Lennert lymphoma
Resembles GA clinically and histo
Rare cd4 systemic lymphoma
Plasmacytoma
MC seen in myeloma (poor prog), may also be associated with tx, extend from bone, poems, Aesop
Anetoderma may show on bx
MC IG is IgG or A
Spicules in MM composed of Abn monoclonal protein
Gingival infiltration
AML
Congenital leukemia cutis
Unlike other lymphomas cutaneous infiltration does not worsen prognosis
May be complicated by linear calcinosis cutis
Polycythemia Vera
Red skin onthe face neck and acral areas
Engorged bluish mm
Telangectasias, epistaxis, bleeding gums, koilonychia
Aquagenic pruritus usually lasts 30-60 min and independent of water temperature - incr of blood and skin histamine
