Pruritus

Question 1

C type fibers are located

Answer 1

Intaepidermal

Question 2

Best for cholestatic pruritus

Answer 2

Opioid antagonist

*serum conjugated bile acid levels do NOT correlate with severity of pruritus

Question 3

MC systemic cause of pruritus

Answer 3

CKD

* due to xerosis, hypervitamintosis a, anemia, hyperpara, increased histamine, neuropathy

Question 4

Mycotic pruritus ani

Answer 4

Candida
Epidermophyton flocc
T rubrum

Question 5

Aquagenic pruritus

Answer 5

Degranulation of MC and increased histamine & ach found

Associated with poly vera, jxg, hypereo syndrome, myelodysplastic syndrome

Question 6

Associated with papuloerythroderma of ofuji

Answer 6

T cell lymphoma, B cell lym, sezary, hep c, aspirin, ranitidine, furosemide

Question 7

MC disorder associated with trichitillomania

Answer 7

OCD

Question 8

Characterized by uncontrollable desire to rub/pinch oneself

Answer 8

Dermatothlasia

Question 9

Burning mouth tx

Answer 9

Antidepressants

Alpha lipoic acid

Question 10

Roth bernhardt syndrome

Answer 10

Meralgia parasthetica

*entrapment of lateral femoral cutaneous nerve

Question 11

What may aid in dx of CRPS

Answer 11

Three-phase technetium bone scan

Question 12

Common complication of crps

Answer 12

Osteoporosis

Question 13

Familial dysautonomia (Riley day)

Answer 13

AR, IKBKAP, abnormality in splicing mRNA
Defective lacrimation, decreased pain, impaired temperature an BP regulation, absent DTRs
Hyperhidosis, transient erythema predominantly on the trunk, acrocyanosis, absence of tongue papillae
Shirmir test positive, intadermal histamine test diminished

Congenital insensitivity to pain with anhidrosis - repeated injury to acral/oral sites, TRKA gene (encodes nerve growth factor)